TOP TEN perturbations for 40010_s_at (Homo sapiens)
Organism: Homo sapiens
Gene: 40010_s_at
Selected probe(set): 206105_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 40010_s_at (206105_at) across 6674 perturbations tested by GENEVESTIGATOR:
stem cell differentiation study 59 (iDRG; 12d) / normal embryonic stem cell sample (WA09)
Relative Expression (log2-ratio):4.207179Number of Samples:4 / 4
Experimental | stem cell differentiation study 59 (iDRG; 12d) |
Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 4 days. Further details are described in the paper. | |
Control | normal embryonic stem cell sample (WA09) |
Undifferentiated WA09 embryonic stem cell samples. |
stem cell differentiation study 59 (iDRG; 15d) / normal embryonic stem cell sample (WA09)
Relative Expression (log2-ratio):3.9936037Number of Samples:4 / 4
Experimental | stem cell differentiation study 59 (iDRG; 15d) |
Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 7 days. Further details are described in the paper. | |
Control | normal embryonic stem cell sample (WA09) |
Undifferentiated WA09 embryonic stem cell samples. |
stem cell differentiation study 59 (iDRG; 9d) / normal embryonic stem cell sample (WA09)
Relative Expression (log2-ratio):3.1932878Number of Samples:4 / 4
Experimental | stem cell differentiation study 59 (iDRG; 9d) |
Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 1 day. Further details are described in the paper. | |
Control | normal embryonic stem cell sample (WA09) |
Undifferentiated WA09 embryonic stem cell samples. |
stem cell differentiation study 59 (8d) / normal embryonic stem cell sample (WA09)
Relative Expression (log2-ratio):2.720458Number of Samples:4 / 4
Experimental | stem cell differentiation study 59 (8d) |
WA09 embryonic stem cell samples differentiated for 8 days. Further details are described in the paper. | |
Control | normal embryonic stem cell sample (WA09) |
Undifferentiated WA09 embryonic stem cell samples. |
gonadotroph adenoma study 1 / normal pituitary gland tissue
Relative Expression (log2-ratio):-2.6831741Number of Samples:7 / 8
Experimental | gonadotroph adenoma study 1 |
Gonadotroph adenoma biopsy samples recovered during transsphenoidal surgery. The tumors were defined as demonstrating positive immunostaining for FSH, LH, or alpha subunit in greater than 5-10% of cells. Samples were scanned between 04/6/2004 - 15/4/2005. | |
Control | normal pituitary gland tissue |
Biopsy samples of healthy pituitary gland recovered post-mortem during autopsy within 2-18 hours of death. Cause of death were mostly various pulmonary or cardiovascular conditions. |
null cell adenoma study 1 / normal pituitary gland tissue
Relative Expression (log2-ratio):-2.640748Number of Samples:2 / 8
Experimental | null cell adenoma study 1 |
Null cell adenoma biopsy samples recovered during transsphenoidal surgery. The tumors were defined by gonadotropic staining for FSH, LH, or alpha subunit in less than 5-10% of cells. Samples were scanned between 04/6/2004 - 15/4/2005. | |
Control | normal pituitary gland tissue |
Biopsy samples of healthy pituitary gland recovered post-mortem during autopsy within 2-18 hours of death. Cause of death were mostly various pulmonary or cardiovascular conditions. |
bone cancer study 1 (PDX; chondrosarcoma, NOS; primary) / bone cancer study 1 (PDX; myxoid chondrosarcoma; primary)
Relative Expression (log2-ratio):-1.912075Number of Samples:2 / 2
Experimental | bone cancer study 1 (PDX; chondrosarcoma, NOS; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary chondrosarcoma, NOS of the bone (subcutaneously implanted). | |
Control | bone cancer study 1 (PDX; myxoid chondrosarcoma; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary myxoid chondrosarcoma of the bone (subcutaneously implanted). |
glioma study 16 (LN-18) / normal astrocyte sample
Relative Expression (log2-ratio):-1.8902836Number of Samples:2 / 3
Experimental | glioma study 16 (LN-18) |
Human glioma cell line LN018 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37C and 5% CO2. | |
Control | normal astrocyte sample |
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations. |
brain tumor study 1 (medulloblastoma) / brain tumor study 1 (ependymoma)
Relative Expression (log2-ratio):1.8514223Number of Samples:22 / 46
Experimental | brain tumor study 1 (medulloblastoma) |
Primary tumor tissue sample from the brain of patients with medulloblastoma. | |
Control | brain tumor study 1 (ependymoma) |
Primary tumor tissue sample from the brain of patients with ependymoma. |
brain tumor study 1 (pilocytic astrocytoma) / brain tumor study 1 (medulloblastoma)
Relative Expression (log2-ratio):-1.7682533Number of Samples:15 / 22
Experimental | brain tumor study 1 (pilocytic astrocytoma) |
Primary tumor tissue sample from the brain of patients with pilocytic astrocytoma. | |
Control | brain tumor study 1 (medulloblastoma) |
Primary tumor tissue sample from the brain of patients with medulloblastoma. |