TOP TEN perturbations for 40019_at (Homo sapiens)
Organism: Homo sapiens
Gene: 40019_at
Selected probe(set): 211742_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 40019_at (211742_s_at) across 6674 perturbations tested by GENEVESTIGATOR:
expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic) / expO ovary cancer study 1 (dysgerminoma; metastatic)
Relative Expression (log2-ratio):-5.5413485Number of Samples:2 / 2
Experimental | expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic) |
Metastatic tumor tissue samples obtained from patients with primary granulosa cell tumor of the ovary. | |
Control | expO ovary cancer study 1 (dysgerminoma; metastatic) |
Metastatic tumor tissue samples obtained from patients with primary dysgerminoma of the ovary. |
expO ovary cancer study 1 (serous cystadenocarcinoma, NOS; metastatic) / expO ovary cancer study 1 (dysgerminoma; metastatic)
Relative Expression (log2-ratio):-4.2854166Number of Samples:8 / 2
Experimental | expO ovary cancer study 1 (serous cystadenocarcinoma, NOS; metastatic) |
Metastatic tumor tissue samples obtained from patients with primary serous cystadenocarcinoma (NOS) of the ovary. | |
Control | expO ovary cancer study 1 (dysgerminoma; metastatic) |
Metastatic tumor tissue samples obtained from patients with primary dysgerminoma of the ovary. |
glioma study 16 (LN-18) / normal astrocyte sample
Relative Expression (log2-ratio):4.233844Number of Samples:2 / 3
Experimental | glioma study 16 (LN-18) |
Human glioma cell line LN018 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37C and 5% CO2. | |
Control | normal astrocyte sample |
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations. |
expO ovary cancer study 1 (endometrioid carcinoma; metastatic) / expO ovary cancer study 1 (dysgerminoma; metastatic)
Relative Expression (log2-ratio):-4.230139Number of Samples:3 / 2
Experimental | expO ovary cancer study 1 (endometrioid carcinoma; metastatic) |
Metastatic tumor tissue samples obtained from patients with primary endometrioid carcinoma of the ovary. | |
Control | expO ovary cancer study 1 (dysgerminoma; metastatic) |
Metastatic tumor tissue samples obtained from patients with primary dysgerminoma of the ovary. |
T-cell activation study 4 / normal resting T-cell sample
Relative Expression (log2-ratio):-4.11738Number of Samples:2 / 2
Experimental | T-cell activation study 4 |
T-cell samples antiCD3 activated for 30hrs. | |
Control | normal resting T-cell sample |
T cells resting for 30h. |
renal cell carcinoma study 4 / normal kidney tissue (fetal)
Relative Expression (log2-ratio):4.116392Number of Samples:26 / 2
Experimental | renal cell carcinoma study 4 |
Tumor tissue samples from the kidney of patients with renal cell carcinoma (RCC). | |
Control | normal kidney tissue (fetal) |
Normal fetal kidney tissue samples. |
T-cell activation study 3 / resting CD4 T-lymphocyte (crude fraction) sample
Relative Expression (log2-ratio):-4.068307Number of Samples:2 / 2
Experimental | T-cell activation study 3 |
CD4+ T-cell samples prepared from crude lymphocyte fraction. Cells were activated with anti-CD3/28 beads for 18hrs. | |
Control | resting CD4 T-lymphocyte (crude fraction) sample |
Resting CD4 T-lymphocytes prepared from crude lymphocyte fraction. |
expO ovary cancer study 1 (serous surface papillary carcinoma; metastatic) / expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic)
Relative Expression (log2-ratio):3.8751717Number of Samples:2 / 2
Experimental | expO ovary cancer study 1 (serous surface papillary carcinoma; metastatic) |
Metastatic tumor tissue samples obtained from patients with primary serous surface papillary carcinoma of the ovary. | |
Control | expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic) |
Metastatic tumor tissue samples obtained from patients with primary granulosa cell tumor of the ovary. |
TNF-ɑ; IL-1b; IL-6; PGE2 study 1 / control antibody treated immature dendritic cell sample
Relative Expression (log2-ratio):-3.7716646Number of Samples:4 / 5
Experimental | TNF-ɑ; IL-1b; IL-6; PGE2 study 1 |
Immature dendritic cells (DCs) treated with inflammatory cytokine cocktail (10 ng/ml IL-1b, 1,000 U/ml IL-6, 10 ng/ml TNF-ɑ, 1μg/ml prostaglandin E2) for 24 h. | |
Control | control antibody treated immature dendritic cell sample |
Immature dendritic cells (DCs) treated with isotype control antibody (10 - 20μg/ml mouse IgG1 isotype) for 24 h. |
VTX-2337 study 1 / untreated monocyte sample
Relative Expression (log2-ratio):-3.7648706Number of Samples:3 / 3
Experimental | VTX-2337 study 1 |
Peripheral blood monocytes isolated from healthy donors. Cells were treated overnight with 1uM VTX-2337 drug, which represents a TLR8 (Toll-like receptor 8) agonist with potential immunostimulating and antineoplastic activities. | |
Control | untreated monocyte sample |
Peripheral blood monocytes isolated from healthy donors. |