TOP TEN perturbations for 40024_at (Homo sapiens)
Organism: Homo sapiens
Gene: 40024_at
Selected probe(set): 205743_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 40024_at (205743_at) across 6674 perturbations tested by GENEVESTIGATOR:
monocyte activation study 1 (NOD2L/TLR/1L; 24h) / untreated monocyte sample (24h)
Relative Expression (log2-ratio):3.4699593Number of Samples:5 / 5
Experimental | monocyte activation study 1 (NOD2L/TLR/1L; 24h) |
Monocytes were isolated from five healthy donors, cultured in RPMI with 10% vitamin D–sufficient (100 nM) human serum and activated for 24 hours with 1 ug/ml muramyl dipeptide (nucleotide-binding oligomerization domain-containing protein 2 ligand, NOD2L) and 1 ug/ml mycobacterial 19-kDa triacylated lipopeptide (TLR2/1 ligand, TLR2/1L). This type of activation is via nucleotide-binding oligomerization domain-containing protein 2 (NOD2) and heterodimeric Toll-like receptor 2 and Toll-like receptor 1 (TLR2/1). | |
Control | untreated monocyte sample (24h) |
Monocytes were isolated from five healthy donors, cultured in RPMI with 10% vitamin D–sufficient (100 nM) human serum and collected after 24 hours for RNA isolation. |
myotonic dystrophy study 4 (deltoid muscle; DM-like) / normal skeletal muscle tisuue (fetal)
Relative Expression (log2-ratio):-3.408512Number of Samples:3 / 3
Experimental | myotonic dystrophy study 4 (deltoid muscle; DM-like) |
Deltoid muscle biopsies obtained from patients with myotonic-like dystrophy (DMx; DM-like; no DMPK or ZNF9 expansion). | |
Control | normal skeletal muscle tisuue (fetal) |
Commercially purchased normal fetal skeletal muscle tissue samples. |
glioma study 16 (LN-18) / normal astrocyte sample
Relative Expression (log2-ratio):-3.4026346Number of Samples:2 / 3
Experimental | glioma study 16 (LN-18) |
Human glioma cell line LN018 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37C and 5% CO2. | |
Control | normal astrocyte sample |
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations. |
myotonic dystrophy study 4 (biceps brachii; DM2) / normal skeletal muscle tisuue (fetal)
Relative Expression (log2-ratio):-3.3358011Number of Samples:3 / 3
Experimental | myotonic dystrophy study 4 (biceps brachii; DM2) |
Biceps brachii biopsies obtained from patients with myotonic dystrophy type 2 (DM2). | |
Control | normal skeletal muscle tisuue (fetal) |
Commercially purchased normal fetal skeletal muscle tissue samples. |
myotonic dystrophy study 4 (biceps brachii; DM1) / normal skeletal muscle tisuue (fetal)
Relative Expression (log2-ratio):-3.3325968Number of Samples:3 / 3
Experimental | myotonic dystrophy study 4 (biceps brachii; DM1) |
Biceps brachii biopsies obtained from patients with myotonic dystrophy type 1 (DM1). | |
Control | normal skeletal muscle tisuue (fetal) |
Commercially purchased normal fetal skeletal muscle tissue samples. |
Becker muscular dystrophy study 3 (biceps brachii) / normal skeletal muscle tisuue (fetal)
Relative Expression (log2-ratio):-3.2898788Number of Samples:3 / 3
Experimental | Becker muscular dystrophy study 3 (biceps brachii) |
Biceps brachii biopsies obtained from patients with Becker muscular dystrophy (BMD). | |
Control | normal skeletal muscle tisuue (fetal) |
Commercially purchased normal fetal skeletal muscle tissue samples. |
myotonic dystrophy study 4 (deltoid muscle; DM2) / normal skeletal muscle tisuue (fetal)
Relative Expression (log2-ratio):-3.2502518Number of Samples:3 / 3
Experimental | myotonic dystrophy study 4 (deltoid muscle; DM2) |
Deltoid muscle biopsies obtained from patients with myotonic dystrophy type 2 (DM2). | |
Control | normal skeletal muscle tisuue (fetal) |
Commercially purchased normal fetal skeletal muscle tissue samples. |
myotonic dystrophy study 4 (skeletal muscle; DM2) / normal skeletal muscle tisuue (fetal)
Relative Expression (log2-ratio):-3.1521826Number of Samples:8 / 3
Experimental | myotonic dystrophy study 4 (skeletal muscle; DM2) |
Unspecified skeletal muscle biopsies obtained from patients with myotonic dystrophy type 2 (DM2). | |
Control | normal skeletal muscle tisuue (fetal) |
Commercially purchased normal fetal skeletal muscle tissue samples. |
glioma study 17 (glioblastoma; A2B5+) / non-tumor oligodendrocyte progenitor cell sample (cortex)
Relative Expression (log2-ratio):3.136684Number of Samples:3 / 3
Experimental | glioma study 17 (glioblastoma; A2B5+) |
Oligodendrocyte progenitor cells (OPC) isolated from high grade glioblastoma (grade IV). OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. Patients were 66 ± 5 years old males. | |
Control | non-tumor oligodendrocyte progenitor cell sample (cortex) |
Oligodendrocyte progenitor cells (OPC) isolated from cortical tissue, which was obtained from patients with epilepsy, but without any manifested brain cancer. OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. |
Duchenne muscular dystrophy study 9 (biceps brachii) / normal skeletal muscle tisuue (fetal)
Relative Expression (log2-ratio):-3.1289196Number of Samples:2 / 3
Experimental | Duchenne muscular dystrophy study 9 (biceps brachii) |
Biceps brachii biopsies obtained from patients with Duchenne muscular dystrophy DMD). | |
Control | normal skeletal muscle tisuue (fetal) |
Commercially purchased normal fetal skeletal muscle tissue samples. |