TOP TEN perturbations for 40035_at (Homo sapiens)
Organism: Homo sapiens
Gene: 40035_at
Selected probe(set): 205470_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 40035_at (205470_s_at) across 6674 perturbations tested by GENEVESTIGATOR:
gefitinib study 2 / wild type A431 cell sample
Relative Expression (log2-ratio):-5.26404Number of Samples:3 / 3
| Experimental | gefitinib study 2 |
| Gefitinib-resistant A431 (A431 GR) cells generated by growing parental cells in the presence of increasing concentrations of gefitinib up to 3 μM. Cells were selected and maintained in gefitinib (3μM). ATC code: | |
| Control | wild type A431 cell sample |
| A431 wild type cells. |
Langerhans cell histiocytosis study 2 (multisystem) / normal epidermal Langerhans cell sample
Relative Expression (log2-ratio):-4.9628334Number of Samples:2 / 10
| Experimental | Langerhans cell histiocytosis study 2 (multisystem) |
| Langerhans cell histiocytes (LCH, CD207+) samples isolated from LCH lesions of patients with multifocal, multisystem (disseminated) disease. Both patients received chemotherapy. Sites of LCH lesions: subj.ID:1 (skin, lungs, multiple skull, mastoid, gingiva), subj.ID:13 (mandible, skull, vertebrae, recurrent orbit, liver, spleen, pituitary gland). | |
| Control | normal epidermal Langerhans cell sample |
| Normal epidermal Langerhans cells (CD207+) were isolated from skin of children donors (age < 18 years). The Langerhans cells were isolated from presumably healthy tissue. |
Langerhans cell histiocytosis study 2 (multifocal) / normal epidermal Langerhans cell sample
Relative Expression (log2-ratio):-4.928529Number of Samples:2 / 10
| Experimental | Langerhans cell histiocytosis study 2 (multifocal) |
| Langerhans cell histiocytes (LCH, CD207+) samples isolated from LCH lesions of patients with multifocal (bone, skin lesions) disease. | |
| Control | normal epidermal Langerhans cell sample |
| Normal epidermal Langerhans cells (CD207+) were isolated from skin of children donors (age < 18 years). The Langerhans cells were isolated from presumably healthy tissue. |
Langerhans cell histiocytosis study 2 (unifocal) / normal epidermal Langerhans cell sample
Relative Expression (log2-ratio):-4.827405Number of Samples:8 / 10
| Experimental | Langerhans cell histiocytosis study 2 (unifocal) |
| Langerhans cell histiocytes (LCH, CD207+) samples isolated from LCH lesions of patients with unifocal, single system disease (bone lesion). | |
| Control | normal epidermal Langerhans cell sample |
| Normal epidermal Langerhans cells (CD207+) were isolated from skin of children donors (age < 18 years). The Langerhans cells were isolated from presumably healthy tissue. |
melanoma study 34 (metastatic) / melanoma study 34 (in situ)
Relative Expression (log2-ratio):-4.7583103Number of Samples:40 / 2
| Experimental | melanoma study 34 (metastatic) |
| Metastatic tumor tissue sample obtained from the patients with metastatic malignant melanoma of the skin. Metastatic samples composed of 22 macroscopic lymph node metastases, 16 subcutaneous metastases and 2 solid organ metastases (adrenal and brain). | |
| Control | melanoma study 34 (in situ) |
| Tumor tissue from the skin of patients with melanoma in situ. |
expO ovary cancer study 1 (mixed epithelial tumor; primary) / expO ovary cancer study 1 (malignant mixed Mullerian tumor; primary)
Relative Expression (log2-ratio):4.7002983Number of Samples:3 / 3
| Experimental | expO ovary cancer study 1 (mixed epithelial tumor; primary) |
| Primary tumor tissue samples obtained from the ovary of patients with mixed epithelial tumor. | |
| Control | expO ovary cancer study 1 (malignant mixed Mullerian tumor; primary) |
| Primary tumor tissue samples obtained from the ovary of patients with malignant mixed Mullerian tumor. |
esophageal adenocarcinoma study 1 / normal esophageal epithelium sample
Relative Expression (log2-ratio):-4.5309525Number of Samples:20 / 18
| Experimental | esophageal adenocarcinoma study 1 |
| Esophageal adenocarcinoma (EAC) samples of affected epithelium recovered by laser capture microdissection technique. | |
| Control | normal esophageal epithelium sample |
| Histologically normal esophageal squamous cell epithelium biopsy samples from patients that were investigated for esophageal pain, but diagnosed as healthy. |
expO ovary cancer study 1 (malignant mixed Mullerian tumor; primary) / expO ovary cancer study 1 (carcinoma, NOS; primary)
Relative Expression (log2-ratio):-4.4942303Number of Samples:3 / 2
| Experimental | expO ovary cancer study 1 (malignant mixed Mullerian tumor; primary) |
| Primary tumor tissue samples obtained from the ovary of patients with malignant mixed Mullerian tumor. | |
| Control | expO ovary cancer study 1 (carcinoma, NOS; primary) |
| Primary tumor tissue samples obtained from the ovary of patients with carcinoma (NOS). |
bronchial epithelial cell differentiation study 1 (day28) / bronchial epithelial cell differentiation study 1 (subconfluent)
Relative Expression (log2-ratio):4.255988Number of Samples:3 / 3
| Experimental | bronchial epithelial cell differentiation study 1 (day28) |
| Differentiated normal human bronchial epithelial cell (NHBE) cultured for 28 days in an air-liquid interface (ALI) system. At this time point cells were fully differentiated and formed a polarized, pseudostratified mucociliary epithelium. In order to generate the ALI culture, undifferentiated cells were grown under submerged conditions in bronchial air-liquid interface (B-ALI) growth basal medium supplemented with expansion media. When cells reached confluency (after 3-5 days), an air-liquid interface culture (ALI system) was created by removing the apical medium and replacing the medium of the basal compartment with B-ALI differentiation medium. During the 28 days culture medium was replaced every 48 hour. | |
| Control | bronchial epithelial cell differentiation study 1 (subconfluent) |
| Subconfluent undifferentiated normal human bronchial epithelial cell (NHBE) cultured for 1-2 days under submerged conditions in bronchial air-liquid interface (B-ALI) growth basal medium supplemented with expansion media. At this time point cells still grew dispersed in the culture insert and covered 70% of the insert. |
bronchial epithelial cell differentiation study 1 (day28) / bronchial epithelial cell differentiation study 1 (confluent)
Relative Expression (log2-ratio):4.2169867Number of Samples:3 / 3
| Experimental | bronchial epithelial cell differentiation study 1 (day28) |
| Differentiated normal human bronchial epithelial cell (NHBE) cultured for 28 days in an air-liquid interface (ALI) system. At this time point cells were fully differentiated and formed a polarized, pseudostratified mucociliary epithelium. In order to generate the ALI culture, undifferentiated cells were grown under submerged conditions in bronchial air-liquid interface (B-ALI) growth basal medium supplemented with expansion media. When cells reached confluency (after 3-5 days), an air-liquid interface culture (ALI system) was created by removing the apical medium and replacing the medium of the basal compartment with B-ALI differentiation medium. During the 28 days culture medium was replaced every 48 hour. | |
| Control | bronchial epithelial cell differentiation study 1 (confluent) |
| Confluent undifferentiated normal human bronchial epithelial cell (NHBE) cultured for 3-5 days under submerged conditions in bronchial air-liquid interface (B-ALI) growth basal medium supplemented with expansion media. At this time point cells formed a monolayer covering the whole surface of the insert. |