TOP TEN perturbations for 40042_r_at (Homo sapiens)
Organism: Homo sapiens
Gene: 40042_r_at
Selected probe(set): 214203_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 40042_r_at (214203_s_at) across 6431 perturbations tested by GENEVESTIGATOR:
colorectal cancer study 43 (metastase; brain) / colorectal cancer study 43 (metastase; lung)
Relative Expression (log2-ratio):5.299073Number of Samples:2 / 5
| Experimental | colorectal cancer study 43 (metastase; brain) |
| Metastatic tumor tissue obtained from the brain of patients with primary colorectal adenocarcinoma. | |
| Control | colorectal cancer study 43 (metastase; lung) |
| Metastatic tumor tissue obtained from the lung of patients with primary colon adenocarcinoma. |
colorectal cancer study 43 (metastase; brain) / colorectal cancer study 43 (metastase; liver)
Relative Expression (log2-ratio):4.98956Number of Samples:2 / 25
| Experimental | colorectal cancer study 43 (metastase; brain) |
| Metastatic tumor tissue obtained from the brain of patients with primary colorectal adenocarcinoma. | |
| Control | colorectal cancer study 43 (metastase; liver) |
| Metastatic tumor tissue obtained from the liver of patients with primary colon adenocarcinoma. |
doxorubicin study 3 / untreated MCF-7 cell sample
Relative Expression (log2-ratio):4.674118Number of Samples:2 / 2
| Experimental | doxorubicin study 3 |
| MCF7 cells treated with 2uM doxorubicin for 24 hours. ATC code: | |
| Control | untreated MCF-7 cell sample |
| MCF-7 cells untreated. |
glycogen storage disease type II study 1 / normal biceps tissue
Relative Expression (log2-ratio):4.0565653Number of Samples:8 / 10
| Experimental | glycogen storage disease type II study 1 |
| Biceps femoris muscle biopsy sample from patients with infantile onset Morbus Pompe (Pompe disease). | |
| Control | normal biceps tissue |
| Biceps femoris biopsy muscle samples from control subjects. |
stem cell differentiation study 41 (T3pi) / undifferentiated hES-T3 cell sample
Relative Expression (log2-ratio):-2.9358559Number of Samples:2 / 3
| Experimental | stem cell differentiation study 41 (T3pi) |
| Sample of pancreatic islet-like cell clusters differentiated from human embryonic stem cells T3 with female karyotype. | |
| Control | undifferentiated hES-T3 cell sample |
| Undifferentiated human embryonic stem cells T3. |
HIF-1a/HIF-2a depletion study 1 (normoxia; AB81) / control AB81 cell sample (normoxia)
Relative Expression (log2-ratio):2.8734455Number of Samples:3 / 3
| Experimental | HIF-1a/HIF-2a depletion study 1 (normoxia; AB81) |
| Human podocyte cells AB81 with shRNA-mediated stable knock-down of HIF-1a and HIF-2a (Hypoxia-inducible factor 1-alpha and Hypoxia-inducible factor 2-alpha) 24 hours after treatment with normoxia (20% O2). Conditionally immortalized human podocytes AB81 were cultured under permissive conditions (33 °C) in RPMI-1640 supplemented with 10% FBS, antibiotics, and 1% ITS. Differentiation was induced by thermoshift to 37 °C in 6-well plates. | |
| Control | control AB81 cell sample (normoxia) |
| Human podocyte cell line AB81 treated with normoxia (20% O2) for 24 hours. Conditionally immortalized human podocytes AB81 were cultured under permissive conditions (33 °C) in RPMI-1640 supplemented with 10% FBS, antibiotics, and 1% ITS. Differentiation was induced by thermoshift to 37 °C in 6-well plates. |
TGF-β study 11 / untreated HCC827 cell sample
Relative Expression (log2-ratio):-2.623417Number of Samples:3 / 3
| Experimental | TGF-β study 11 |
| HCC827 cells were cultured for 3-5 weeks in the presence of 2ng/ml of TGF-β, to induce epithelial-mesenchymal transition (EMT). 24 hours prior analysis cells were re-seeded without TGF-β. | |
| Control | untreated HCC827 cell sample |
| HCC827 cells grown in standard media. |
Hep-G2 / HepaRG
Relative Expression (log2-ratio):-2.6106606Number of Samples:9 / 12
| Experimental | Hep-G2 |
| Human primary cancer cell line derived from the liver of a patient with hepatocellular carcinoma. Synonyms:HEP-G2; Hep G2; HEP G2; HepG2; HEPG2 Cellosaurus code: | |
| Control | HepaRG |
| Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code: |
atypical teratoid/rhabdoid tumor study 1 / medulloblastoma study 2
Relative Expression (log2-ratio):2.5904255Number of Samples:20 / 4
| Experimental | atypical teratoid/rhabdoid tumor study 1 |
| Primary tumor tissue sample from the brain of pediatric patients with atypical teratoid/rhabdoid tumor (AT/RT). | |
| Control | medulloblastoma study 2 |
| Primary tumor tissue sample from the infratentorial brain of pediatric patients with large-cell anaplastic medulloblastoma. |
transwell differentiation study 1 (TEER mid) / untreated MCF10A cell sample
Relative Expression (log2-ratio):2.5418596Number of Samples:3 / 3
| Experimental | transwell differentiation study 1 (TEER mid) |
| MCF10A cells were plated onto polyester permeable supports (Transwells) at a density of 10^5 cells/cm^2. Midpoint represents those plates with a mid trans-epithelial electrical resistance (TEER) of 1400-1600 Ohms x cm^2. | |
| Control | untreated MCF10A cell sample |
| MCF10A cells grown to confluency on sterile plastic. |
Organism: Homo sapiens
Gene: 40042_r_at
Selected probe(set): 214203_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 40042_r_at (214203_s_at) across 6431 perturbations tested by GENEVESTIGATOR:
colorectal cancer study 43 (metastase; brain) / colorectal cancer study 43 (metastase; lung)
Relative Expression (log2-ratio):5.299073Number of Samples:2 / 5
| Experimental | colorectal cancer study 43 (metastase; brain) |
| Metastatic tumor tissue obtained from the brain of patients with primary colorectal adenocarcinoma. | |
| Control | colorectal cancer study 43 (metastase; lung) |
| Metastatic tumor tissue obtained from the lung of patients with primary colon adenocarcinoma. |
colorectal cancer study 43 (metastase; brain) / colorectal cancer study 43 (metastase; liver)
Relative Expression (log2-ratio):4.98956Number of Samples:2 / 25
| Experimental | colorectal cancer study 43 (metastase; brain) |
| Metastatic tumor tissue obtained from the brain of patients with primary colorectal adenocarcinoma. | |
| Control | colorectal cancer study 43 (metastase; liver) |
| Metastatic tumor tissue obtained from the liver of patients with primary colon adenocarcinoma. |
doxorubicin study 3 / untreated MCF-7 cell sample
Relative Expression (log2-ratio):4.674118Number of Samples:2 / 2
| Experimental | doxorubicin study 3 |
| MCF7 cells treated with 2uM doxorubicin for 24 hours. ATC code: | |
| Control | untreated MCF-7 cell sample |
| MCF-7 cells untreated. |
glycogen storage disease type II study 1 / normal biceps tissue
Relative Expression (log2-ratio):4.0565653Number of Samples:8 / 10
| Experimental | glycogen storage disease type II study 1 |
| Biceps femoris muscle biopsy sample from patients with infantile onset Morbus Pompe (Pompe disease). | |
| Control | normal biceps tissue |
| Biceps femoris biopsy muscle samples from control subjects. |
stem cell differentiation study 41 (T3pi) / undifferentiated hES-T3 cell sample
Relative Expression (log2-ratio):-2.9358559Number of Samples:2 / 3
| Experimental | stem cell differentiation study 41 (T3pi) |
| Sample of pancreatic islet-like cell clusters differentiated from human embryonic stem cells T3 with female karyotype. | |
| Control | undifferentiated hES-T3 cell sample |
| Undifferentiated human embryonic stem cells T3. |
HIF-1a/HIF-2a depletion study 1 (normoxia; AB81) / control AB81 cell sample (normoxia)
Relative Expression (log2-ratio):2.8734455Number of Samples:3 / 3
| Experimental | HIF-1a/HIF-2a depletion study 1 (normoxia; AB81) |
| Human podocyte cells AB81 with shRNA-mediated stable knock-down of HIF-1a and HIF-2a (Hypoxia-inducible factor 1-alpha and Hypoxia-inducible factor 2-alpha) 24 hours after treatment with normoxia (20% O2). Conditionally immortalized human podocytes AB81 were cultured under permissive conditions (33 °C) in RPMI-1640 supplemented with 10% FBS, antibiotics, and 1% ITS. Differentiation was induced by thermoshift to 37 °C in 6-well plates. | |
| Control | control AB81 cell sample (normoxia) |
| Human podocyte cell line AB81 treated with normoxia (20% O2) for 24 hours. Conditionally immortalized human podocytes AB81 were cultured under permissive conditions (33 °C) in RPMI-1640 supplemented with 10% FBS, antibiotics, and 1% ITS. Differentiation was induced by thermoshift to 37 °C in 6-well plates. |
TGF-β study 11 / untreated HCC827 cell sample
Relative Expression (log2-ratio):-2.623417Number of Samples:3 / 3
| Experimental | TGF-β study 11 |
| HCC827 cells were cultured for 3-5 weeks in the presence of 2ng/ml of TGF-β, to induce epithelial-mesenchymal transition (EMT). 24 hours prior analysis cells were re-seeded without TGF-β. | |
| Control | untreated HCC827 cell sample |
| HCC827 cells grown in standard media. |
Hep-G2 / HepaRG
Relative Expression (log2-ratio):-2.6106606Number of Samples:9 / 12
| Experimental | Hep-G2 |
| Human primary cancer cell line derived from the liver of a patient with hepatocellular carcinoma. Synonyms:HEP-G2; Hep G2; HEP G2; HepG2; HEPG2 Cellosaurus code: | |
| Control | HepaRG |
| Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code: |
atypical teratoid/rhabdoid tumor study 1 / medulloblastoma study 2
Relative Expression (log2-ratio):2.5904255Number of Samples:20 / 4
| Experimental | atypical teratoid/rhabdoid tumor study 1 |
| Primary tumor tissue sample from the brain of pediatric patients with atypical teratoid/rhabdoid tumor (AT/RT). | |
| Control | medulloblastoma study 2 |
| Primary tumor tissue sample from the infratentorial brain of pediatric patients with large-cell anaplastic medulloblastoma. |
transwell differentiation study 1 (TEER mid) / untreated MCF10A cell sample
Relative Expression (log2-ratio):2.5418596Number of Samples:3 / 3
| Experimental | transwell differentiation study 1 (TEER mid) |
| MCF10A cells were plated onto polyester permeable supports (Transwells) at a density of 10^5 cells/cm^2. Midpoint represents those plates with a mid trans-epithelial electrical resistance (TEER) of 1400-1600 Ohms x cm^2. | |
| Control | untreated MCF10A cell sample |
| MCF10A cells grown to confluency on sterile plastic. |