TOP TEN perturbations for 40050_at (Homo sapiens)
Organism: Homo sapiens
Gene: 40050_at
Selected probe(set): 207625_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 40050_at (207625_s_at) across 6674 perturbations tested by GENEVESTIGATOR:
stem cell differentiation study 59 (8d) / normal embryonic stem cell sample (WA09)
Relative Expression (log2-ratio):2.710269Number of Samples:4 / 4
| Experimental | stem cell differentiation study 59 (8d) |
| WA09 embryonic stem cell samples differentiated for 8 days. Further details are described in the paper. | |
| Control | normal embryonic stem cell sample (WA09) |
| Undifferentiated WA09 embryonic stem cell samples. |
exercise study 33 (OUT; fast twitch; post-exerc.) / exercise study 33 (YT; fast twitch; post-exerc.)
Relative Expression (log2-ratio):2.4587545Number of Samples:3 / 6
| Experimental | exercise study 33 (OUT; fast twitch; post-exerc.) |
| Fast twitch myosin heavy chain muscle fibers (MHC) IIa were obtained from vastus lateralis muscle. Biopsies were taken from old untrained (OUT) women (85±1 years) 4 hours after the first resistance exercise. Fibers were separated under the light microscope and MHC isoform was determinated based on SDS-PAGE analysis. Exclusion criteria: acute/chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin or non-insulin-dependent diabetes, abnormal blood, or urine chemistries, arthritis, a history of neuromuscular problems, tobacco smoking. Individuals, that had ever completed any formal exercise programs or physical activity outside of their activities of daily living, were excluded as well. | |
| Control | exercise study 33 (YT; fast twitch; post-exerc.) |
| Fast twitch myosin heavy chain muscle fibers (MHC) IIa were obtained from vastus lateralis muscle. Biopsies were taken from young trained (YT) women (23±2 years old) 4 hours after the 36th (last) exercise session. Participants underwent 12 weeks of progressive resistance training including 36 training sessions (3 days/week) with three sets of 10 bilateral knee extensions at 70–75% of their one-repetition maximum (1 RM). Fibers were separated under the light microscope and MHC isoform was determinated based on SDS-PAGE analysis. Exclusion criteria: acute/chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin or non-insulin-dependent diabetes, abnormal blood, or urine chemistries, arthritis, a history of neuromuscular problems, tobacco smoking. Individuals, that had ever completed any formal exercise programs or physical activity outside of their activities of daily living, were excluded as well. |
stem cell differentiation study 59 (iDRG; 9d) / normal embryonic stem cell sample (WA09)
Relative Expression (log2-ratio):2.3675861Number of Samples:4 / 4
| Experimental | stem cell differentiation study 59 (iDRG; 9d) |
| Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 1 day. Further details are described in the paper. | |
| Control | normal embryonic stem cell sample (WA09) |
| Undifferentiated WA09 embryonic stem cell samples. |
T-cell activation study 2 / quiescent CD4+ T-cell sample
Relative Expression (log2-ratio):-2.2664824Number of Samples:2 / 2
| Experimental | T-cell activation study 2 |
| CD4+ T-cell samples derived from PBMC´s of HIV-seronegative donors were activated with plate bound CD3 (1ug/ml) and soluble CD28 (50ng/ml) for 2 days.. | |
| Control | quiescent CD4+ T-cell sample |
| Quiescent CD4+ T-cell samples derived from PBMC´s of HIV-seronegative donors. |
Merkel cell carcinoma study 3 (primary) / basal cell carcinoma study 2
Relative Expression (log2-ratio):2.260518Number of Samples:19 / 2
| Experimental | Merkel cell carcinoma study 3 (primary) |
| Primary tumor tissue from the skin of patients with Merkel cell carcinoma. | |
| Control | basal cell carcinoma study 2 |
| Primary tumor tissue from the skin of patients with basal cell carcinoma (BCC). |
PMA; ionomycine study 2 / unstimulated CD4 memory T-cell sample
Relative Expression (log2-ratio):-2.242259Number of Samples:8 / 8
| Experimental | PMA; ionomycine study 2 |
| CD4+ memory T cells derived from peripheral blood of healthy subjects were stimulated for 3 hours with phorbol 12-myristate 13-acetate (PMA, 10 ng/ml) and ionomycin (1 µg/ml). ATC code:--- | |
| Control | unstimulated CD4 memory T-cell sample |
| Unstimulated CD4+ memory T cells derived from peripheral blood of healthy subjects. |
CH5183284 study 1 (HSC-39) / vehicle (DMSO) treated HSC-39 cell sample
Relative Expression (log2-ratio):2.196764Number of Samples:2 / 2
| Experimental | CH5183284 study 1 (HSC-39) |
| Human gastric cell line HSC-39 treated with 1 uM of FGFR inhibitor CH5183284 for 24 hours. ATC code:--- | |
| Control | vehicle (DMSO) treated HSC-39 cell sample |
| Human gastric cell line HSC-39 treated with 0.1% DMSO for 24 hours. |
T-cell activation study 1 / quiescent CD4+ T-cell sample
Relative Expression (log2-ratio):-2.1642246Number of Samples:2 / 2
| Experimental | T-cell activation study 1 |
| CD4+ T-cell samples derived from PBMC´s of HIV-seronegative donors were activated with plate bound CD3 (1ug/ml) and soluble CD28 (50ng/ml) for 1 day. | |
| Control | quiescent CD4+ T-cell sample |
| Quiescent CD4+ T-cell samples derived from PBMC´s of HIV-seronegative donors. |
brain tumor study 1 (pilocytic astrocytoma) / brain tumor study 1 (medulloblastoma)
Relative Expression (log2-ratio):-2.0679483Number of Samples:15 / 22
| Experimental | brain tumor study 1 (pilocytic astrocytoma) |
| Primary tumor tissue sample from the brain of patients with pilocytic astrocytoma. | |
| Control | brain tumor study 1 (medulloblastoma) |
| Primary tumor tissue sample from the brain of patients with medulloblastoma. |
stem cell differentiation study 59 (iDRG; 15d) / stem cell differentiation study 59 (8d)
Relative Expression (log2-ratio):-1.9866695Number of Samples:4 / 4
| Experimental | stem cell differentiation study 59 (iDRG; 15d) |
| Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 7 days. Further details are described in the paper. | |
| Control | stem cell differentiation study 59 (8d) |
| WA09 embryonic stem cell samples differentiated for 8 days. Further details are described in the paper. |