TOP TEN perturbations for 40061_at (Homo sapiens)
Organism: Homo sapiens
Gene: 40061_at
Selected probe(set): 202925_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 40061_at (202925_s_at) across 6674 perturbations tested by GENEVESTIGATOR:
T-cell activation study 3 / resting CD4 T-lymphocyte (crude fraction) sample
Relative Expression (log2-ratio):3.1317196Number of Samples:2 / 2
Experimental | T-cell activation study 3 |
CD4+ T-cell samples prepared from crude lymphocyte fraction. Cells were activated with anti-CD3/28 beads for 18hrs. | |
Control | resting CD4 T-lymphocyte (crude fraction) sample |
Resting CD4 T-lymphocytes prepared from crude lymphocyte fraction. |
T-cell activation study 1 / quiescent CD4+ T-cell sample
Relative Expression (log2-ratio):2.96237Number of Samples:2 / 2
Experimental | T-cell activation study 1 |
CD4+ T-cell samples derived from PBMC´s of HIV-seronegative donors were activated with plate bound CD3 (1ug/ml) and soluble CD28 (50ng/ml) for 1 day. | |
Control | quiescent CD4+ T-cell sample |
Quiescent CD4+ T-cell samples derived from PBMC´s of HIV-seronegative donors. |
colorectal cancer study 33 (carcinoma; colonic mucosa) / normal colon mucosa sample
Relative Expression (log2-ratio):2.8771286Number of Samples:5 / 5
Experimental | colorectal cancer study 33 (carcinoma; colonic mucosa) |
Colonic mucosa samples obtained by laser capture microdissection (LCM) from patients with colorectal carcinoma. | |
Control | normal colon mucosa sample |
Histopathological normal colon mucosa sample obtained by laser capture microdissection (LCM) from the distant normal colon of patients with colorectal cancer. |
Hep-G2 / HepaRG
Relative Expression (log2-ratio):2.6907425Number of Samples:9 / 12
Experimental | Hep-G2 |
Human primary cancer cell line derived from the liver of a patient with hepatocellular carcinoma. Synonyms:HEP-G2; Hep G2; HEP G2; HepG2; HEPG2 Cellosaurus code: | |
Control | HepaRG |
Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code: |
renal cell carcinoma study 6 (chromophobe type) / normal kidney tissue (adult)
Relative Expression (log2-ratio):2.6689014Number of Samples:4 / 3
Experimental | renal cell carcinoma study 6 (chromophobe type) |
Tumor tissue samples from the kidney of patients with chromophobe renal cell carcinoma (cRCC). | |
Control | normal kidney tissue (adult) |
Normal adult kidney tissue samples. |
T-cell activation study 4 / normal resting T-cell sample
Relative Expression (log2-ratio):2.6479454Number of Samples:2 / 2
Experimental | T-cell activation study 4 |
T-cell samples antiCD3 activated for 30hrs. | |
Control | normal resting T-cell sample |
T cells resting for 30h. |
VTX-2337 study 1 / untreated monocyte sample
Relative Expression (log2-ratio):2.641343Number of Samples:3 / 3
Experimental | VTX-2337 study 1 |
Peripheral blood monocytes isolated from healthy donors. Cells were treated overnight with 1uM VTX-2337 drug, which represents a TLR8 (Toll-like receptor 8) agonist with potential immunostimulating and antineoplastic activities. | |
Control | untreated monocyte sample |
Peripheral blood monocytes isolated from healthy donors. |
hepatocyte (ESC) / HepaRG
Relative Expression (log2-ratio):2.6180887Number of Samples:8 / 12
Experimental | hepatocyte (ESC) |
Hepatocyte-like cells differentiated from embryonic stem cells (ESC) | |
Control | HepaRG |
Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code: |
T-cell activation study 2 / quiescent CD4+ T-cell sample
Relative Expression (log2-ratio):2.5844698Number of Samples:2 / 2
Experimental | T-cell activation study 2 |
CD4+ T-cell samples derived from PBMC´s of HIV-seronegative donors were activated with plate bound CD3 (1ug/ml) and soluble CD28 (50ng/ml) for 2 days.. | |
Control | quiescent CD4+ T-cell sample |
Quiescent CD4+ T-cell samples derived from PBMC´s of HIV-seronegative donors. |
rheumatoid arthritis study 31 / TNF-ɑ study 20
Relative Expression (log2-ratio):-2.5351114Number of Samples:4 / 3
Experimental | rheumatoid arthritis study 31 |
Monocyte samples isolated from patients with rheumatoid arthritis (RA). Monocytes from whole blood were depleted from granulocytes by CD15 MACS beads, and afterwards they were sorted from remaining peripheral blood leukocytes by CD14 labeling. Patients fulfilled the revised American College of Rheumatology criteria (ACR) for RA. | |
Control | TNF-ɑ study 20 |
Monocyte samples isolated from healthy donors and stimulated in vitro by 100 ng/ml TNFα in whole blood for 1.5 hour. Following stimulation, monocytes were depleted from granulocytes using CD15 MACS beads, and afterwards they were sorted from remaining peripheral blood leukocytes by CD14 labeling. |