TOP TEN perturbations for 40087_at (Homo sapiens)
Organism: Homo sapiens
Gene: 40087_at
Selected probe(set): 202893_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 40087_at (202893_at) across 6674 perturbations tested by GENEVESTIGATOR:
Langerhans cell histiocytosis study 1 / normal plasmocytoid dendritic cell sample
Relative Expression (log2-ratio):3.7556171Number of Samples:7 / 3
Experimental | Langerhans cell histiocytosis study 1 |
Langerhans cell histiocytes (LCH) were isolated from LCH lesions of patients undergoing surgery. All patients had single system disease, five patients had bone lesion, one had skin lesion and one had mucosal manifestation. Langerhans cells histiocytes were purified by FACS as CD1a+ / CD270 + population with > 95% purity. | |
Control | normal plasmocytoid dendritic cell sample |
Normal plasmocytoid dendritic cells were isolated from peripheral blood of healthy adult donors. Plasmocytoid dendritic cells were defined as HLA-DR+ / CD45RAhi / CD11c- / BDCA2+ population. |
zalypsis study 1 / untreated MM1S cell sample
Relative Expression (log2-ratio):-2.939104Number of Samples:2 / 2
Experimental | zalypsis study 1 |
MM1S multiple myeloma cells treated in vitro with zalypsis (5 nM), a novel marine-derived compound with potent antimyeloma activity. Cells were harvested at the beginning of induction of cell death (15-20% cell death as assessed by Annexin V-FITC staining). ATC code:--- | |
Control | untreated MM1S cell sample |
MM1S multiple myeloma cells untreated. |
AsPC-1 / BxPC-3
Relative Expression (log2-ratio):2.8322601Number of Samples:3 / 3
Experimental | AsPC-1 |
Human xenograft derived metastatic cancer cell line derived from mouse xenografts initiated with metastatic cells from the ascites derived from a 62 years old female Caucasian patient with pancreatic adenocarcinoma. Synonyms:AsPc-1; Aspc-1; ASPC-1; As-PC1; ASPC1; AsPC1; Aspc1; AsPc1 Cellosaurus code: | |
Control | BxPC-3 |
Human pancreatic adenocarcinoma cell line derived from a 61 years old female patient. Synonyms:BxPc-3; BXPC-3; Bx-PC3; BXPC3; BxPC3; BxPc3 Cellosaurus code: |
OPM-1 / MM1.S
Relative Expression (log2-ratio):-2.6270962Number of Samples:4 / 4
Experimental | OPM-1 |
Human primary cancer cell line derived from the peripheral blood of a patient with multiple myeloma. Dexamethasone-resistant. Synonyms:OPM1 Cellosaurus code: | |
Control | MM1.S |
Human primary cancer cell line derived from the peripheral blood of a patient with multiple myeloma. Dexamethasone-sensitive. Parental cell line:: MM.1 Synonyms:MM.1S; MM1-S; MM-1S; MM1S Cellosaurus code: |
expO lung cancer study 1 (squamous cell carcinoma, NOS; primary) / expO lung cancer study 1 (papillary adenocarcinoma, NOS; primary)
Relative Expression (log2-ratio):-2.3788223Number of Samples:40 / 2
Experimental | expO lung cancer study 1 (squamous cell carcinoma, NOS; primary) |
Primary tumor tissue samples obtained from the lung of patients with squamous cell carcinoma (NOS). | |
Control | expO lung cancer study 1 (papillary adenocarcinoma, NOS; primary) |
Primary tumor tissue samples obtained from the lung of patients with papillary adenocarcinoma (NOS). |
bone cancer study 1 (PDX; chondrosarcoma, NOS; primary) / bone cancer study 1 (PDX; myxoid chondrosarcoma; primary)
Relative Expression (log2-ratio):2.3708792Number of Samples:2 / 2
Experimental | bone cancer study 1 (PDX; chondrosarcoma, NOS; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary chondrosarcoma, NOS of the bone (subcutaneously implanted). | |
Control | bone cancer study 1 (PDX; myxoid chondrosarcoma; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary myxoid chondrosarcoma of the bone (subcutaneously implanted). |
Langerhans cell histiocytosis study 1 / normal myeloid dendritic cell sample
Relative Expression (log2-ratio):2.3694477Number of Samples:7 / 3
Experimental | Langerhans cell histiocytosis study 1 |
Langerhans cell histiocytes (LCH) were isolated from LCH lesions of patients undergoing surgery. All patients had single system disease, five patients had bone lesion, one had skin lesion and one had mucosal manifestation. Langerhans cells histiocytes were purified by FACS as CD1a+ / CD270 + population with > 95% purity. | |
Control | normal myeloid dendritic cell sample |
Normal myeloid dendritic cells were isolated from peripheral blood of healthy adult donors. Myeloid dendritic cells were defined as HLA-DR+ / CD11c + / BDCA1+ / BDCA3- population. |
myotonic dystrophy study 4 (skeletal muscle; DM2) / normal skeletal muscle tissue (adult)
Relative Expression (log2-ratio):2.3446932Number of Samples:8 / 6
Experimental | myotonic dystrophy study 4 (skeletal muscle; DM2) |
Unspecified skeletal muscle biopsies obtained from patients with myotonic dystrophy type 2 (DM2). | |
Control | normal skeletal muscle tissue (adult) |
Commercially purchased normal adult skeletal muscle tissue samples. |
expO lung cancer study 1 (papillary adenocarcinoma, NOS; primary) / expO lung cancer study 1 (large cell carcinoma, NOS; primary)
Relative Expression (log2-ratio):2.3030195Number of Samples:2 / 9
Experimental | expO lung cancer study 1 (papillary adenocarcinoma, NOS; primary) |
Primary tumor tissue samples obtained from the lung of patients with papillary adenocarcinoma (NOS). | |
Control | expO lung cancer study 1 (large cell carcinoma, NOS; primary) |
Primary tumor tissue samples obtained from the lung of patients with large cell carcinoma (NOS). |
ovarian tumor study 30 (PDX; transitional cell carcinoma, NOS; primary) / ovarian tumor study 30 (PDX; serous cystadenocarcinoma, NOS; primary)
Relative Expression (log2-ratio):2.2482042Number of Samples:2 / 13
Experimental | ovarian tumor study 30 (PDX; transitional cell carcinoma, NOS; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary transitional cell carcinoma, NOS of the ovary (subcutaneously implanted). | |
Control | ovarian tumor study 30 (PDX; serous cystadenocarcinoma, NOS; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary serous cystadenocarcinoma, NOS of the ovary (subcutaneously implanted). |