TOP TEN perturbations for 40091_at (Homo sapiens)
Organism: Homo sapiens
Gene: 40091_at
Selected probe(set): 203140_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 40091_at (203140_at) across 6674 perturbations tested by GENEVESTIGATOR:
VSVG-pseudo. HIV-1 study 1 (Env-Nef-) / control VSVG infected CD4 T-lymphocyte sample
Relative Expression (log2-ratio):4.0457563Number of Samples:3 / 3
Experimental | VSVG-pseudo. HIV-1 study 1 (Env-Nef-) |
CD4+ T-lymphocytes infected with vesicular stomatitis virus G protein (VSVG) -pseudotyped HIV-1 viruses lacking Env and Nef. Cells were sorted 48 hours after infection using GFP as a marker of infectivity. | |
Control | control VSVG infected CD4 T-lymphocyte sample |
CD4+ T-lymphocytes were infected with vesicular stomatitis virus G protein (VSVG) -pseudotyped eGFP. Cells were sorted 48 hours after infection using GFP as a marker of infectivity. |
dexamethasone study 9 (24h) / EtOH treated CCRF-CEM-C7H2 cell sample
Relative Expression (log2-ratio):3.926467Number of Samples:3 / 3
Experimental | dexamethasone study 9 (24h) |
CCRF-CEM-C7H2 cells cultured in the presence of dexamethansone (10e-7M) for 24 hours. ATC code:, , , , , , , , , , | |
Control | EtOH treated CCRF-CEM-C7H2 cell sample |
CCRF-CEM-C7H2 cells treated for 24 hours with 0.1% ethanol (EtOH) as carrier control. |
echinomycin study 1 / deferoxamine study 5
Relative Expression (log2-ratio):-3.9203873Number of Samples:3 / 3
Experimental | echinomycin study 1 |
Echinomycin (100nM; 2h) treated human astroglioma (U251) cells, stimulated with deferoxamine (DFO; 300mM; 16h). ATC code:--- | |
Control | deferoxamine study 5 |
Untreated human astroglioma (U251) cells, stimulated with deferoxamine (DFO; 300mM; 16h). ATC code: |
bronchial epithelial cell differentiation study 1 (day28) / bronchial epithelial cell differentiation study 1 (subconfluent)
Relative Expression (log2-ratio):3.9119806Number of Samples:3 / 3
Experimental | bronchial epithelial cell differentiation study 1 (day28) |
Differentiated normal human bronchial epithelial cell (NHBE) cultured for 28 days in an air-liquid interface (ALI) system. At this time point cells were fully differentiated and formed a polarized, pseudostratified mucociliary epithelium. In order to generate the ALI culture, undifferentiated cells were grown under submerged conditions in bronchial air-liquid interface (B-ALI) growth basal medium supplemented with expansion media. When cells reached confluency (after 3-5 days), an air-liquid interface culture (ALI system) was created by removing the apical medium and replacing the medium of the basal compartment with B-ALI differentiation medium. During the 28 days culture medium was replaced every 48 hour. | |
Control | bronchial epithelial cell differentiation study 1 (subconfluent) |
Subconfluent undifferentiated normal human bronchial epithelial cell (NHBE) cultured for 1-2 days under submerged conditions in bronchial air-liquid interface (B-ALI) growth basal medium supplemented with expansion media. At this time point cells still grew dispersed in the culture insert and covered 70% of the insert. |
OPM-1 / MM1.S
Relative Expression (log2-ratio):3.6575851Number of Samples:4 / 4
Experimental | OPM-1 |
Human primary cancer cell line derived from the peripheral blood of a patient with multiple myeloma. Dexamethasone-resistant. Synonyms:OPM1 Cellosaurus code: | |
Control | MM1.S |
Human primary cancer cell line derived from the peripheral blood of a patient with multiple myeloma. Dexamethasone-sensitive. Parental cell line:: MM.1 Synonyms:MM.1S; MM1-S; MM-1S; MM1S Cellosaurus code: |
medulloblastoma study 2 / non-tumor brain tissue
Relative Expression (log2-ratio):-3.5879536Number of Samples:4 / 9
Experimental | medulloblastoma study 2 |
Primary tumor tissue sample from the infratentorial brain of pediatric patients with large-cell anaplastic medulloblastoma. | |
Control | non-tumor brain tissue |
Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor. |
myotonic dystrophy study 4 (skeletal muscle; DM1) / normal skeletal muscle tisuue (fetal)
Relative Expression (log2-ratio):3.5708227Number of Samples:5 / 3
Experimental | myotonic dystrophy study 4 (skeletal muscle; DM1) |
Unspecified skeletal muscle biopsies obtained from patients with myotonic dystrophy type 1 (DM1). | |
Control | normal skeletal muscle tisuue (fetal) |
Commercially purchased normal fetal skeletal muscle tissue samples. |
bronchial epithelial cell differentiation study 1 (day28) / bronchial epithelial cell differentiation study 1 (confluent)
Relative Expression (log2-ratio):3.4461498Number of Samples:3 / 3
Experimental | bronchial epithelial cell differentiation study 1 (day28) |
Differentiated normal human bronchial epithelial cell (NHBE) cultured for 28 days in an air-liquid interface (ALI) system. At this time point cells were fully differentiated and formed a polarized, pseudostratified mucociliary epithelium. In order to generate the ALI culture, undifferentiated cells were grown under submerged conditions in bronchial air-liquid interface (B-ALI) growth basal medium supplemented with expansion media. When cells reached confluency (after 3-5 days), an air-liquid interface culture (ALI system) was created by removing the apical medium and replacing the medium of the basal compartment with B-ALI differentiation medium. During the 28 days culture medium was replaced every 48 hour. | |
Control | bronchial epithelial cell differentiation study 1 (confluent) |
Confluent undifferentiated normal human bronchial epithelial cell (NHBE) cultured for 3-5 days under submerged conditions in bronchial air-liquid interface (B-ALI) growth basal medium supplemented with expansion media. At this time point cells formed a monolayer covering the whole surface of the insert. |
PMA study 3 (shRNA contr.) / mock treated / transduced Jurkat cell sample
Relative Expression (log2-ratio):3.3567495Number of Samples:2 / 2
Experimental | PMA study 3 (shRNA contr.) |
Jurkat cells were transduced with a control shRNA and then treated with 10 ng/ml phorbol 12-myristate 13-acetate (PMA). ATC code:--- | |
Control | mock treated / transduced Jurkat cell sample |
Jurkat cells were transduced with a control shRNA and then mock treated. |
ovulation study 2 / proliferative phase endometrium tissue
Relative Expression (log2-ratio):3.3183126Number of Samples:8 / 4
Experimental | ovulation study 2 |
Mid secretory phase (MSE) endometrium tissue. | |
Control | proliferative phase endometrium tissue |
Proliferative phase (PE) endometrium tissue. |