TOP TEN perturbations for 40091_at (Homo sapiens)

Organism: Homo sapiens
Gene: 40091_at
Selected probe(set): 203140_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 40091_at (203140_at) across 6674 perturbations tested by GENEVESTIGATOR:

VSVG-pseudo. HIV-1 study 1 (Env-Nef-) / control VSVG infected CD4 T-lymphocyte sample

Relative Expression (log2-ratio):4.0457563
Number of Samples:3 / 3
Experimental VSVG-pseudo. HIV-1 study 1 (Env-Nef-)
CD4+ T-lymphocytes infected with vesicular stomatitis virus G protein (VSVG) -pseudotyped HIV-1 viruses lacking Env and Nef. Cells were sorted 48 hours after infection using GFP as a marker of infectivity.
Control control VSVG infected CD4 T-lymphocyte sample
CD4+ T-lymphocytes were infected with vesicular stomatitis virus G protein (VSVG) -pseudotyped eGFP. Cells were sorted 48 hours after infection using GFP as a marker of infectivity.

dexamethasone study 9 (24h) / EtOH treated CCRF-CEM-C7H2 cell sample

Relative Expression (log2-ratio):3.926467
Number of Samples:3 / 3
Experimental dexamethasone study 9 (24h)
CCRF-CEM-C7H2 cells cultured in the presence of dexamethansone (10e-7M) for 24 hours. ATC code:, , , , , , , , , ,
Control EtOH treated CCRF-CEM-C7H2 cell sample
CCRF-CEM-C7H2 cells treated for 24 hours with 0.1% ethanol (EtOH) as carrier control.

echinomycin study 1 / deferoxamine study 5

Relative Expression (log2-ratio):-3.9203873
Number of Samples:3 / 3
Experimental echinomycin study 1
Echinomycin (100nM; 2h) treated human astroglioma (U251) cells, stimulated with deferoxamine (DFO; 300mM; 16h). ATC code:---
Control deferoxamine study 5
Untreated human astroglioma (U251) cells, stimulated with deferoxamine (DFO; 300mM; 16h). ATC code:

bronchial epithelial cell differentiation study 1 (day28) / bronchial epithelial cell differentiation study 1 (subconfluent)

Relative Expression (log2-ratio):3.9119806
Number of Samples:3 / 3
Experimental bronchial epithelial cell differentiation study 1 (day28)
Differentiated normal human bronchial epithelial cell (NHBE) cultured for 28 days in an air-liquid interface (ALI) system. At this time point cells were fully differentiated and formed a polarized, pseudostratified mucociliary epithelium. In order to generate the ALI culture, undifferentiated cells were grown under submerged conditions in bronchial air-liquid interface (B-ALI) growth basal medium supplemented with expansion media. When cells reached confluency (after 3-5 days), an air-liquid interface culture (ALI system) was created by removing the apical medium and replacing the medium of the basal compartment with B-ALI differentiation medium. During the 28 days culture medium was replaced every 48 hour.
Control bronchial epithelial cell differentiation study 1 (subconfluent)
Subconfluent undifferentiated normal human bronchial epithelial cell (NHBE) cultured for 1-2 days under submerged conditions in bronchial air-liquid interface (B-ALI) growth basal medium supplemented with expansion media. At this time point cells still grew dispersed in the culture insert and covered 70% of the insert.

OPM-1 / MM1.S

Relative Expression (log2-ratio):3.6575851
Number of Samples:4 / 4
Experimental OPM-1
Human primary cancer cell line derived from the peripheral blood of a patient with multiple myeloma. Dexamethasone-resistant. Synonyms:OPM1 Cellosaurus code:
Control MM1.S
Human primary cancer cell line derived from the peripheral blood of a patient with multiple myeloma. Dexamethasone-sensitive. Parental cell line:: MM.1 Synonyms:MM.1S; MM1-S; MM-1S; MM1S Cellosaurus code:

medulloblastoma study 2 / non-tumor brain tissue

Relative Expression (log2-ratio):-3.5879536
Number of Samples:4 / 9
Experimental medulloblastoma study 2
Primary tumor tissue sample from the infratentorial brain of pediatric patients with large-cell anaplastic medulloblastoma.
Control non-tumor brain tissue
Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor.

myotonic dystrophy study 4 (skeletal muscle; DM1) / normal skeletal muscle tisuue (fetal)

Relative Expression (log2-ratio):3.5708227
Number of Samples:5 / 3
Experimental myotonic dystrophy study 4 (skeletal muscle; DM1)
Unspecified skeletal muscle biopsies obtained from patients with myotonic dystrophy type 1 (DM1).
Control normal skeletal muscle tisuue (fetal)
Commercially purchased normal fetal skeletal muscle tissue samples.

bronchial epithelial cell differentiation study 1 (day28) / bronchial epithelial cell differentiation study 1 (confluent)

Relative Expression (log2-ratio):3.4461498
Number of Samples:3 / 3
Experimental bronchial epithelial cell differentiation study 1 (day28)
Differentiated normal human bronchial epithelial cell (NHBE) cultured for 28 days in an air-liquid interface (ALI) system. At this time point cells were fully differentiated and formed a polarized, pseudostratified mucociliary epithelium. In order to generate the ALI culture, undifferentiated cells were grown under submerged conditions in bronchial air-liquid interface (B-ALI) growth basal medium supplemented with expansion media. When cells reached confluency (after 3-5 days), an air-liquid interface culture (ALI system) was created by removing the apical medium and replacing the medium of the basal compartment with B-ALI differentiation medium. During the 28 days culture medium was replaced every 48 hour.
Control bronchial epithelial cell differentiation study 1 (confluent)
Confluent undifferentiated normal human bronchial epithelial cell (NHBE) cultured for 3-5 days under submerged conditions in bronchial air-liquid interface (B-ALI) growth basal medium supplemented with expansion media. At this time point cells formed a monolayer covering the whole surface of the insert.

PMA study 3 (shRNA contr.) / mock treated / transduced Jurkat cell sample

Relative Expression (log2-ratio):3.3567495
Number of Samples:2 / 2
Experimental PMA study 3 (shRNA contr.)
Jurkat cells were transduced with a control shRNA and then treated with 10 ng/ml phorbol 12-myristate 13-acetate (PMA). ATC code:---
Control mock treated / transduced Jurkat cell sample
Jurkat cells were transduced with a control shRNA and then mock treated.

ovulation study 2 / proliferative phase endometrium tissue

Relative Expression (log2-ratio):3.3183126
Number of Samples:8 / 4
Experimental ovulation study 2
Mid secretory phase (MSE) endometrium tissue.
Control proliferative phase endometrium tissue
Proliferative phase (PE) endometrium tissue.