TOP TEN perturbations for 41469_at (Homo sapiens)

Organism: Homo sapiens
Gene: 41469_at
Selected probe(set): 203691_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 41469_at (203691_at) across 6673 perturbations tested by GENEVESTIGATOR:

skin transplantation study 1 (7d) / split-thickness skin grafting study 1

Relative Expression (log2-ratio):7.967395
Number of Samples:5 / 6
Experimental skin transplantation study 1 (7d)
Human skin punch biopsy from patients after skin grafting. Sample was taken at the site of re-epithelialization 7 days after surgery.
Control split-thickness skin grafting study 1
Skin punch biopsy from patients with skin injury (burn injury, congelation, wound, compartment syndrome) immediately after split-thickness skin grafting was done. Sample was taken from the acute wound after grafting.

skin squamous cell carcinoma study 6 / normal skin tissue

Relative Expression (log2-ratio):7.6545067
Number of Samples:4 / 64
Experimental skin squamous cell carcinoma study 6
Primary tumor tissue from the skin of patients with squamous cell carcinoma (SCC).
Control normal skin tissue
Normal skin samples from healthy donors.

gefitinib study 2 / wild type A431 cell sample

Relative Expression (log2-ratio):-7.575198
Number of Samples:3 / 3
Experimental gefitinib study 2
Gefitinib-resistant A431 (A431 GR) cells generated by growing parental cells in the presence of increasing concentrations of gefitinib up to 3 μM. Cells were selected and maintained in gefitinib (3μM). ATC code:
Control wild type A431 cell sample
A431 wild type cells.

skin transplantation study 1 (3d) / split-thickness skin grafting study 1

Relative Expression (log2-ratio):7.4446573
Number of Samples:6 / 6
Experimental skin transplantation study 1 (3d)
Human skin punch biopsy from patients after skin grafting. Sample was taken at the site of re-epithelialization 3 days after surgery.
Control split-thickness skin grafting study 1
Skin punch biopsy from patients with skin injury (burn injury, congelation, wound, compartment syndrome) immediately after split-thickness skin grafting was done. Sample was taken from the acute wound after grafting.

psoriasis study 4 (lesional) / normal skin tissue

Relative Expression (log2-ratio):7.0415792
Number of Samples:58 / 64
Experimental psoriasis study 4 (lesional)
Lesional skin punch biopsies derived from patients with psoriasis. A 6mm punch biopsy was obtained from lesional skin (psoriasis plaque). Psoriasis patients had one or more psoriatic plaques not limited to the scalp region (if only one plaque was available this had to be greater than 1% of the total body area). No systemic anti-psoriatic treatments were used for two weeks prior to biopsy, and no topical treatments were used for one week prior to biopsy.
Control normal skin tissue
Normal skin punch biopsies (6mm) derived from healthy control subjects.

F. tularensis study 1 (tularensis Schu S4) / uninfected peripheral blood monocyte sample

Relative Expression (log2-ratio):6.969062
Number of Samples:4 / 6
Experimental F. tularensis study 1 (tularensis Schu S4)
Peripheral blood monocytes infected with the Schu S4 isolate of Francisella tularensis (100 MOI) for 24 hours.
Control uninfected peripheral blood monocyte sample
Peripheral blood monocytes uninfected.

split-thickness skin grafting study 2 (w/o NPWT) / normal skin tissue (skin grafting)

Relative Expression (log2-ratio):6.8887215
Number of Samples:2 / 6
Experimental split-thickness skin grafting study 2 (w/o NPWT)
Skin punch biopsy from patients that underwent split-thickness skin grafting. Sample was taken from the wound site 7 days after grafting. Patients did not receive negative-pressure wound therapy (NPWT).
Control normal skin tissue (skin grafting)
Skin punch biopsy samples from healthy patients before slit-thickness skin grafting.

Merkel cell carcinoma study 3 (primary) / skin squamous cell carcinoma study 6

Relative Expression (log2-ratio):-6.8834925
Number of Samples:19 / 4
Experimental Merkel cell carcinoma study 3 (primary)
Primary tumor tissue from the skin of patients with Merkel cell carcinoma.
Control skin squamous cell carcinoma study 6
Primary tumor tissue from the skin of patients with squamous cell carcinoma (SCC).

split-thickness skin grafting study 2 (NPWT) / normal skin tissue (skin grafting)

Relative Expression (log2-ratio):6.767948
Number of Samples:4 / 6
Experimental split-thickness skin grafting study 2 (NPWT)
Skin punch biopsy from patients that underwent split-thickness skin grafting. Sample was taken from the wound site 7 days after grafting. Patients received negative-pressure wound therapy (NPWT) immediately after grafting .
Control normal skin tissue (skin grafting)
Skin punch biopsy samples from healthy patients before slit-thickness skin grafting.

skin transplantation study 1 (7d) / normal skin tissue (skin grafting)

Relative Expression (log2-ratio):6.692115
Number of Samples:5 / 8
Experimental skin transplantation study 1 (7d)
Human skin punch biopsy from patients after skin grafting. Sample was taken at the site of re-epithelialization 7 days after surgery.
Control normal skin tissue (skin grafting)
Skin biopsy samples from healthy control subjects after breast or abdomen reduction surgery.