TOP TEN perturbations for 41827_f_at (Homo sapiens)

Organism: Homo sapiens
Gene: 41827_f_at
Selected probe(set): 213502_x_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 41827_f_at (213502_x_at) across 6672 perturbations tested by GENEVESTIGATOR:

expO ovary cancer study 1 (endometrioid carcinoma; metastatic) / expO ovary cancer study 1 (dysgerminoma; metastatic)

Relative Expression (log2-ratio):-3.2733784
Number of Samples:3 / 2
Experimental expO ovary cancer study 1 (endometrioid carcinoma; metastatic)
Metastatic tumor tissue samples obtained from patients with primary endometrioid carcinoma of the ovary.
Control expO ovary cancer study 1 (dysgerminoma; metastatic)
Metastatic tumor tissue samples obtained from patients with primary dysgerminoma of the ovary.

microcrystalline arthritis study 1 / rheumatoid arthritis study 2

Relative Expression (log2-ratio):-3.0549326
Number of Samples:5 / 7
Experimental microcrystalline arthritis study 1
Synovial membrane tissue samples from patients with microcrystalline arthritis. The samples were collected by needle arthroscopy of affected knee. For RNA extraction, 4 – 6 synovial biopsy samples were used. The diagnosis of microcrystalline arthritis was based on the identification of urate or calcium pyrophosphate crystals in the synovial fluid. All patients had a swollen knee at the time of tissue collection. Patients were naive to any immunosuppressive therapy, only some of them were receiving nonsteroidal antiinflammatory drugs (NSAID).
Control rheumatoid arthritis study 2
Synovial membrane tissue samples from patients with active rheumatoid arthritis (RA). All patients met the ACR classification criteria of RA diagnosis (1987). All had early disease duration (< 1 year) and swollen knee at the time of tissue collection. The samples were collected by needle arthroscopy of affected knee. For RNA extraction, 4 – 6 synovial biopsy samples were used. Patients were naive to any disease-modifying antirheumatic drugs or any immunosuppressive therapy, only some of them were receiving nonsteroidal antiinflammatory drugs (NSAID).

expO ovary cancer study 1 (mucinous adenocarcinoma; metastatic) / expO ovary cancer study 1 (dysgerminoma; metastatic)

Relative Expression (log2-ratio):-2.9315863
Number of Samples:2 / 2
Experimental expO ovary cancer study 1 (mucinous adenocarcinoma; metastatic)
Metastatic tumor tissue samples obtained from patients with primary mucinous adenocarcinoma of the ovary.
Control expO ovary cancer study 1 (dysgerminoma; metastatic)
Metastatic tumor tissue samples obtained from patients with primary dysgerminoma of the ovary.

Rosacea study 1 (PhR) / normal skin tissue

Relative Expression (log2-ratio):2.8780136
Number of Samples:12 / 20
Experimental Rosacea study 1 (PhR)
Skin biopsy samples from patients with phymatous rosacea (PhR), diagnosed in accordance with classification system of the American Rosacea Society. Skin biopsies were taken from nasolabial fold.
Control normal skin tissue
Normal skin biopsy samples from healthy individuals.

expO ovary cancer study 1 (serous surface papillary carcinoma; metastatic) / expO ovary cancer study 1 (endometrioid carcinoma; metastatic)

Relative Expression (log2-ratio):2.845398
Number of Samples:2 / 3
Experimental expO ovary cancer study 1 (serous surface papillary carcinoma; metastatic)
Metastatic tumor tissue samples obtained from patients with primary serous surface papillary carcinoma of the ovary.
Control expO ovary cancer study 1 (endometrioid carcinoma; metastatic)
Metastatic tumor tissue samples obtained from patients with primary endometrioid carcinoma of the ovary.

expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic) / expO ovary cancer study 1 (dysgerminoma; metastatic)

Relative Expression (log2-ratio):-2.8336582
Number of Samples:2 / 2
Experimental expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic)
Metastatic tumor tissue samples obtained from patients with primary granulosa cell tumor of the ovary.
Control expO ovary cancer study 1 (dysgerminoma; metastatic)
Metastatic tumor tissue samples obtained from patients with primary dysgerminoma of the ovary.

rheumatoid arthritis study 2 / osteoarthritis study 4

Relative Expression (log2-ratio):2.7917156
Number of Samples:7 / 5
Experimental rheumatoid arthritis study 2
Synovial membrane tissue samples from patients with active rheumatoid arthritis (RA). All patients met the ACR classification criteria of RA diagnosis (1987). All had early disease duration (< 1 year) and swollen knee at the time of tissue collection. The samples were collected by needle arthroscopy of affected knee. For RNA extraction, 4 – 6 synovial biopsy samples were used. Patients were naive to any disease-modifying antirheumatic drugs or any immunosuppressive therapy, only some of them were receiving nonsteroidal antiinflammatory drugs (NSAID).
Control osteoarthritis study 4
Synovial membrane tissue samples from patients with active osteoarthritis. The samples were collected by needle arthroscopy of affected knee. For RNA extraction, 4 – 6 synovial biopsy samples were used. All patients had a swollen knee at the time of tissue collection. The diagnosis was established based on x-ray evidence of osteoarthritis. Patients were naive to any immunosuppressive therapy, only some of them were receiving nonsteroidal antiinflammatory drugs (NSAID).

expO renal pelvis cancer study 1 (transitional cell carcinoma, NOS; primary) / expO renal pelvis cancer study 1 (papillary transitional cell carcinoma; primary)

Relative Expression (log2-ratio):2.7158985
Number of Samples:5 / 4
Experimental expO renal pelvis cancer study 1 (transitional cell carcinoma, NOS; primary)
Primary tumor tissue samples obtained from the renal pelvis of patients with transitional cell carcinoma (NOS).
Control expO renal pelvis cancer study 1 (papillary transitional cell carcinoma; primary)
Primary tumor tissue samples obtained from the renal pelvis of patients with papillary transitional cell carcinoma.

aortic valve stenosis study 9 (stenotic) / normal aortic valve leaflet tissue

Relative Expression (log2-ratio):2.6617184
Number of Samples:5 / 5
Experimental aortic valve stenosis study 9 (stenotic)
Stenotic aortic valve leaflet tissue samples obtained from patients with calcific aortic valve disease (CAVD). Aortic valves were removed from patients undergoing valve or aortic root surgery. Patients had non-rheumatic, severe aortic valve stenosis with varying degrees of calcification. None of patients suffered from diabetes mellitus, peripheral atherosclerosis, or chronic obstructive pulmonary disease. One patient was diagnosed with coronary disease. Further patients’ characteristics (expressed as mean ± SD or percentage): bicuspid valve 20%, age (yrs) 56.8±9.9 (45-72), LVEF (%) 57.8±14.9.
Control normal aortic valve leaflet tissue
Normal aortic valve leaflet tissue samples obtained from patients undergoing valve or aortic root surgery due to ascending aortic pathology (aneurysm or dissection) or aortic regurgitation. None of patients suffered from diabetes mellitus, coronary disease, peripheral atherosclerosis, or chronic obstructive pulmonary disease. Further patients’ characteristics (expressed as mean ± SD or percentage): bicuspid valve 40%, age (yrs) 43.8±18.4 (31-69), LVEF (%) 56.6±6.5.

kidney transplantation study 16 (2 week) / normal natural killer cell (CD56+) sample

Relative Expression (log2-ratio):-2.6380997
Number of Samples:3 / 3
Experimental kidney transplantation study 16 (2 week)
CD56+ natural killer cell samples derived from kidney transplant patients 2 weeks post-transplantation. Samples were collected 2 week after transplantation and administration of immunosuppressive therapy (day 1-4: methylprednisolone (60 mg); 3 doses: rabbit polyclonal anti-thymocyte globulin (ThymoglobulinH; 6 mg/kg); mycophenolate mofetil (CellCeptH); and tacrolimus (PrografH).
Control normal natural killer cell (CD56+) sample
CD56+ natural killer cell samples derived from healthy control subjects.

Organism: Homo sapiens
Gene: 41827_f_at
Selected probe(set): 213502_x_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 41827_f_at (213502_x_at) across 6672 perturbations tested by GENEVESTIGATOR:

expO ovary cancer study 1 (endometrioid carcinoma; metastatic) / expO ovary cancer study 1 (dysgerminoma; metastatic)

Relative Expression (log2-ratio):-3.2733784
Number of Samples:3 / 2
Experimental expO ovary cancer study 1 (endometrioid carcinoma; metastatic)
Metastatic tumor tissue samples obtained from patients with primary endometrioid carcinoma of the ovary.
Control expO ovary cancer study 1 (dysgerminoma; metastatic)
Metastatic tumor tissue samples obtained from patients with primary dysgerminoma of the ovary.

microcrystalline arthritis study 1 / rheumatoid arthritis study 2

Relative Expression (log2-ratio):-3.0549326
Number of Samples:5 / 7
Experimental microcrystalline arthritis study 1
Synovial membrane tissue samples from patients with microcrystalline arthritis. The samples were collected by needle arthroscopy of affected knee. For RNA extraction, 4 – 6 synovial biopsy samples were used. The diagnosis of microcrystalline arthritis was based on the identification of urate or calcium pyrophosphate crystals in the synovial fluid. All patients had a swollen knee at the time of tissue collection. Patients were naive to any immunosuppressive therapy, only some of them were receiving nonsteroidal antiinflammatory drugs (NSAID).
Control rheumatoid arthritis study 2
Synovial membrane tissue samples from patients with active rheumatoid arthritis (RA). All patients met the ACR classification criteria of RA diagnosis (1987). All had early disease duration (< 1 year) and swollen knee at the time of tissue collection. The samples were collected by needle arthroscopy of affected knee. For RNA extraction, 4 – 6 synovial biopsy samples were used. Patients were naive to any disease-modifying antirheumatic drugs or any immunosuppressive therapy, only some of them were receiving nonsteroidal antiinflammatory drugs (NSAID).

expO ovary cancer study 1 (mucinous adenocarcinoma; metastatic) / expO ovary cancer study 1 (dysgerminoma; metastatic)

Relative Expression (log2-ratio):-2.9315863
Number of Samples:2 / 2
Experimental expO ovary cancer study 1 (mucinous adenocarcinoma; metastatic)
Metastatic tumor tissue samples obtained from patients with primary mucinous adenocarcinoma of the ovary.
Control expO ovary cancer study 1 (dysgerminoma; metastatic)
Metastatic tumor tissue samples obtained from patients with primary dysgerminoma of the ovary.

Rosacea study 1 (PhR) / normal skin tissue

Relative Expression (log2-ratio):2.8780136
Number of Samples:12 / 20
Experimental Rosacea study 1 (PhR)
Skin biopsy samples from patients with phymatous rosacea (PhR), diagnosed in accordance with classification system of the American Rosacea Society. Skin biopsies were taken from nasolabial fold.
Control normal skin tissue
Normal skin biopsy samples from healthy individuals.

expO ovary cancer study 1 (serous surface papillary carcinoma; metastatic) / expO ovary cancer study 1 (endometrioid carcinoma; metastatic)

Relative Expression (log2-ratio):2.845398
Number of Samples:2 / 3
Experimental expO ovary cancer study 1 (serous surface papillary carcinoma; metastatic)
Metastatic tumor tissue samples obtained from patients with primary serous surface papillary carcinoma of the ovary.
Control expO ovary cancer study 1 (endometrioid carcinoma; metastatic)
Metastatic tumor tissue samples obtained from patients with primary endometrioid carcinoma of the ovary.

expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic) / expO ovary cancer study 1 (dysgerminoma; metastatic)

Relative Expression (log2-ratio):-2.8336582
Number of Samples:2 / 2
Experimental expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic)
Metastatic tumor tissue samples obtained from patients with primary granulosa cell tumor of the ovary.
Control expO ovary cancer study 1 (dysgerminoma; metastatic)
Metastatic tumor tissue samples obtained from patients with primary dysgerminoma of the ovary.

rheumatoid arthritis study 2 / osteoarthritis study 4

Relative Expression (log2-ratio):2.7917156
Number of Samples:7 / 5
Experimental rheumatoid arthritis study 2
Synovial membrane tissue samples from patients with active rheumatoid arthritis (RA). All patients met the ACR classification criteria of RA diagnosis (1987). All had early disease duration (< 1 year) and swollen knee at the time of tissue collection. The samples were collected by needle arthroscopy of affected knee. For RNA extraction, 4 – 6 synovial biopsy samples were used. Patients were naive to any disease-modifying antirheumatic drugs or any immunosuppressive therapy, only some of them were receiving nonsteroidal antiinflammatory drugs (NSAID).
Control osteoarthritis study 4
Synovial membrane tissue samples from patients with active osteoarthritis. The samples were collected by needle arthroscopy of affected knee. For RNA extraction, 4 – 6 synovial biopsy samples were used. All patients had a swollen knee at the time of tissue collection. The diagnosis was established based on x-ray evidence of osteoarthritis. Patients were naive to any immunosuppressive therapy, only some of them were receiving nonsteroidal antiinflammatory drugs (NSAID).

expO renal pelvis cancer study 1 (transitional cell carcinoma, NOS; primary) / expO renal pelvis cancer study 1 (papillary transitional cell carcinoma; primary)

Relative Expression (log2-ratio):2.7158985
Number of Samples:5 / 4
Experimental expO renal pelvis cancer study 1 (transitional cell carcinoma, NOS; primary)
Primary tumor tissue samples obtained from the renal pelvis of patients with transitional cell carcinoma (NOS).
Control expO renal pelvis cancer study 1 (papillary transitional cell carcinoma; primary)
Primary tumor tissue samples obtained from the renal pelvis of patients with papillary transitional cell carcinoma.

aortic valve stenosis study 9 (stenotic) / normal aortic valve leaflet tissue

Relative Expression (log2-ratio):2.6617184
Number of Samples:5 / 5
Experimental aortic valve stenosis study 9 (stenotic)
Stenotic aortic valve leaflet tissue samples obtained from patients with calcific aortic valve disease (CAVD). Aortic valves were removed from patients undergoing valve or aortic root surgery. Patients had non-rheumatic, severe aortic valve stenosis with varying degrees of calcification. None of patients suffered from diabetes mellitus, peripheral atherosclerosis, or chronic obstructive pulmonary disease. One patient was diagnosed with coronary disease. Further patients’ characteristics (expressed as mean ± SD or percentage): bicuspid valve 20%, age (yrs) 56.8±9.9 (45-72), LVEF (%) 57.8±14.9.
Control normal aortic valve leaflet tissue
Normal aortic valve leaflet tissue samples obtained from patients undergoing valve or aortic root surgery due to ascending aortic pathology (aneurysm or dissection) or aortic regurgitation. None of patients suffered from diabetes mellitus, coronary disease, peripheral atherosclerosis, or chronic obstructive pulmonary disease. Further patients’ characteristics (expressed as mean ± SD or percentage): bicuspid valve 40%, age (yrs) 43.8±18.4 (31-69), LVEF (%) 56.6±6.5.

kidney transplantation study 16 (2 week) / normal natural killer cell (CD56+) sample

Relative Expression (log2-ratio):-2.6380997
Number of Samples:3 / 3
Experimental kidney transplantation study 16 (2 week)
CD56+ natural killer cell samples derived from kidney transplant patients 2 weeks post-transplantation. Samples were collected 2 week after transplantation and administration of immunosuppressive therapy (day 1-4: methylprednisolone (60 mg); 3 doses: rabbit polyclonal anti-thymocyte globulin (ThymoglobulinH; 6 mg/kg); mycophenolate mofetil (CellCeptH); and tacrolimus (PrografH).
Control normal natural killer cell (CD56+) sample
CD56+ natural killer cell samples derived from healthy control subjects.