Organism: Homo sapiens
Gene: ZBED6CL
Selected probe(set): 227598_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of ZBED6CL (227598_at) across 6540 perturbations tested by GENEVESTIGATOR:

Relative Expression (log2-ratio):-2.5416737
Number of Samples:8 / 9

Experimental	hepatocyte (ESC)
	Hepatocyte-like cells differentiated from embryonic stem cells (ESC)
Control	Hep-G2
	Human primary cancer cell line derived from the liver of a patient with hepatocellular carcinoma. Synonyms:HEP-G2; Hep G2; HEP G2; HepG2; HEPG2 Cellosaurus code:

Relative Expression (log2-ratio):-2.4731379
Number of Samples:8 / 12

Experimental	hepatocyte (ESC)
	Hepatocyte-like cells differentiated from embryonic stem cells (ESC)
Control	HepaRG
	Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code:

Relative Expression (log2-ratio):-2.4524622
Number of Samples:3 / 3

Experimental	CD44s overexpr. study 1
	Human embryonic kidney cell line HEK-293 transfected with pcDNA3.1(-) vector containing codon-optimized human CD44 sequence for expression.
Control	normal HEK-293 cell sample
	Untransfected, native human embryonic kidney cell line HEK-293 cell samples.

Relative Expression (log2-ratio):-2.2890196
Number of Samples:2 / 7

Experimental	pancreatic islet study 3 (re-differentiated; PPRF; 8d)
	Human pancreatic islets were isolated from a cadaveric donor. The population was 70% pure in mature islets, which was determined by dithizone staining. Islets cells were expanded for 6 weeks and re-differentiated for 8 days according to Pharmaceutical Production Research Facility (PPRF) Protocol. Re-differentiation phase: For induction of expanded cells to differentiate into islet-like cell clusters, the cells were seeded into 60 mm ultra-low attachment dishes in serum-free CMRL-1066 supplemented with 4 mM L-glutamine, 1% BSA, insulin (10 g/ml), transferrin (5.5 g/ml), sodium selenite (6.7ng/ml), and 1% antibiotic antimycotic solution at a density of 6.0 x 10EXP6 cells per dish. The induction medium was further added with islet neogenesis-associated protein (INGAP) peptide at a concentration of 1.0 ug/ml.
Control	normal pancreatic islet sample
	Pancreatic islets were obtained from seven donors aged between 37 and 70 years and body mass index between 22 and 27. Functional islets were cultured in CMRL 1066 supplemented with 10% FCS, 1% glutamine, 5.6 mM glucose, 1 mM HEPES, 110 U/ml penicillin, and 110 g/ml streptomycin for 7 days or immediately processed after isolation.

Relative Expression (log2-ratio):-2.2273598
Number of Samples:2 / 2

Experimental	theophylline study 5 (10000uM)
	Hepatocytes treated with compound: theophylline (10000uM; CHEMBL190) for 24 hours. ATC code:
Control	vehicle (medium) treated hepatocyte sample
	Hepatocytes treated with vehicle (medium) for 24 hours.

Relative Expression (log2-ratio):2.1902256
Number of Samples:2 / 2

Experimental	CNS cancer study 1 (PDX; glioma, malignant, NOS; primary)
	Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary glioma, malignant, NOS of the central nervous system (subcutaneously implanted).
Control	CNS cancer study 1 (PDX; ependymoma, NOS; primary)
	Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary ependymoma, NOS of the central nervous system (subcutaneously implanted).

Relative Expression (log2-ratio):-2.1151495
Number of Samples:2 / 7

Experimental	pancreatic islet study 3 (expanded; PPRF)
	Human pancreatic islets were isolated from a cadaveric donor. The population was 70% pure in mature islets, which was determined by dithizone staining. Islets cells were expanded according to Pharmaceutical Production Research Facility Protocol (PPRF) for 6 weeks. Expansion phase: Approximately 2,500 islet equivalents were seeded onto 75-cm2 fibronectin-coated tissue culture-treated flasks in a proprietary serum-free medium (PPRF medium). The serum-free PPRF medium was supplemented with 30% serum-free mesenchymal-conditioned medium. When the cell migration resulted in the formation of large-size colonies, the cells were harvested by trypsinization and replated into new tissue culture flasks. Once the cells reached near confluence (80–90%) in monolayer, they were trypsinized, counted, and subcultured at a density of 5,000 cells per cm2. Thereafter, cells were serially passaged using the same protocol.
Control	normal pancreatic islet sample
	Pancreatic islets were obtained from seven donors aged between 37 and 70 years and body mass index between 22 and 27. Functional islets were cultured in CMRL 1066 supplemented with 10% FCS, 1% glutamine, 5.6 mM glucose, 1 mM HEPES, 110 U/ml penicillin, and 110 g/ml streptomycin for 7 days or immediately processed after isolation.

Relative Expression (log2-ratio):2.099018
Number of Samples:3 / 3

Experimental	renal cell carcinoma study 1 (prim. tumor)
	Tumor tissue from the primary tumor of patients with renal cell carcinoma (RCC).
Control	adjacent kidney tissue
	Histologically normal tissue from an unaffected site (renal tubules) of patients with renal cell carcinoma (RCC) of the clear cell type.

Relative Expression (log2-ratio):2.0976734
Number of Samples:2 / 3

Experimental	CNS cancer study 1 (PDX; glioma, malignant, NOS; primary)
	Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary glioma, malignant, NOS of the central nervous system (subcutaneously implanted).
Control	CNS cancer study 1 (PDX; glioblastoma, NOS; primary)
	Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary glioblastoma, NOS of the central nervous system (subcutaneously implanted).

Relative Expression (log2-ratio):2.0861177
Number of Samples:5 / 5

Experimental	antibody study 1 (anti-FcgRIIB)
	Immature dendritic cells (DCs) treated with 10 - 20 μg/ml anti-FcgRIIB antibody for 24 h. ATC code:---
Control	control antibody treated immature dendritic cell sample
	Immature dendritic cells (DCs) treated with isotype control antibody (10 - 20μg/ml mouse IgG1 isotype) for 24 h.