TOP TEN perturbations for 28894 (Homo sapiens)

Organism: Homo sapiens
Gene: 28894
Selected probe(set): 216401_x_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 28894 (216401_x_at) across 5392 perturbations tested by GENEVESTIGATOR:

osteoarthritis study 4 / rheumatoid arthritis study 2

Relative Expression (log2-ratio):-5.6349077
Number of Samples:5 / 6
Experimental osteoarthritis study 4
Synovial tissue biopsy from a swollen knee of patients with osteoarthritis (active disease). Patients were naive to any immunosuppressive therapy, only some of them were receiving nonsteroidal antiinflammatory drugs (NSAID).
Control rheumatoid arthritis study 2
Synovial tissues from rheumatoid arthritis patients.

microcrystalline arthritis study 1 / rheumatoid arthritis study 2

Relative Expression (log2-ratio):-5.069866
Number of Samples:4 / 6
Experimental microcrystalline arthritis study 1
Synovial tissue biopsy from a swollen knee of patients with microcristalline arthritis (active disease). The diagnosis of microcrystalline arthritis was based on the identification of urate or calcium pyrophosphate crystals in the synovial fluid. Patients were naive to any immunosuppressive therapy, only some of them were receiving nonsteroidal antiinflammatory drugs (NSAID).
Control rheumatoid arthritis study 2
Synovial tissues from rheumatoid arthritis patients.

seronegative arthritis study 1 / rheumatoid arthritis study 2

Relative Expression (log2-ratio):-4.770262
Number of Samples:4 / 6
Experimental seronegative arthritis study 1
Synovial tissue biopsy from a swollen knee of patients with seronegative arthritis (active disease). The diagnosis of seronegative arthritis was based on the presence of psoriasis or x-ray evidence of sacro-iliacal joint involvement. Patients were naive to any immunosuppressive therapy, only some of them were receiving nonsteroidal antiinflammatory drugs (NSAID).
Control rheumatoid arthritis study 2
Synovial tissues from rheumatoid arthritis patients.

inclusion body myositis study 1 / normal biceps tissue

Relative Expression (log2-ratio):4.548952
Number of Samples:5 / 3
Experimental inclusion body myositis study 1
Biceps femoris biopsy muscle samples from patients with clinical diagnosis of inclusion body myositis (IBM).
Control normal biceps tissue
Biceps femoris biopsy muscle samples from control subjects.

rheumatoid arthritis study 1 / normal synovial membrane tissue

Relative Expression (log2-ratio):4.38999
Number of Samples:5 / 6
Experimental rheumatoid arthritis study 1
Synovial membrane tissue from patients with rheumatoid arthritis.
Control normal synovial membrane tissue
Normal synovial membrane tissue.

osteoarthritis study 4 / lupus arthritis study 1

Relative Expression (log2-ratio):-4.361327
Number of Samples:5 / 4
Experimental osteoarthritis study 4
Synovial tissue biopsy from a swollen knee of patients with osteoarthritis (active disease). Patients were naive to any immunosuppressive therapy, only some of them were receiving nonsteroidal antiinflammatory drugs (NSAID).
Control lupus arthritis study 1
Synovial tissue biopsy from a swollen knee of patients with systemic lupus erythematosus (SLE) associated arthritis (active disease). All patients with SLE met the American College of Rheumatology (ACR) revised classification criteria for SLE. Patients were naive to any immunosuppressive therapy, only some of them were receiving nonsteroidal antiinflammatory drugs (NSAID).

HCV-related HCC study 1 / adjacent HCV-related liver tissue (LC)

Relative Expression (log2-ratio):-4.3096533
Number of Samples:5 / 4
Experimental HCV-related HCC study 1
Hepatitis C infection related human hepatocellular carcinoma sample.
Control adjacent HCV-related liver tissue (LC)
Histologically normal adjacent liver tissue of a patient with Hepatitis C infection related hepatocellular carcinoma. Patient with liver cirrhosis.

multiple sclerosis study 10 (PP-MS) / cerebrospinal fluid cell sample (mixed neuropathologies)

Relative Expression (log2-ratio):4.2073984
Number of Samples:10 / 9
Experimental multiple sclerosis study 10 (PP-MS)
Cerebrospinal fluid (CSF) cell samples from patients with primary progressive multiple sclerosis (PP-MS). Active disease was defined by the presence of any of the following criteria during 6 month prior CSF collection: (1) one or more relapses, (2) change of 0.5 point or greater in EDSS (Expanded Disability Status Score), (3) change in the number and size of lesions visualized by gadolinium-enhanced MRI. Untreated MS patients did not receive any medication for at least 1 year before CSF sample collection.
Control cerebrospinal fluid cell sample (mixed neuropathologies)
Cerebrospinal fluid (CSF) cell samples from patients with different neuropathologies, other than multiple sclerosis.

lung adenocarcinoma study 9 (metastase; lymph node) / lung adenocarcinoma study 9 (metastase; brain)

Relative Expression (log2-ratio):4.144106
Number of Samples:3 / 6
Experimental lung adenocarcinoma study 9 (metastase; lymph node)
Metastatic tumor tissue obtained from the lymph node of patients with primary lung adenocarcinoma.
Control lung adenocarcinoma study 9 (metastase; brain)
Metastatic tumor tissue obtained from the brain of patients with primary lung adenocarcinoma.

kidney transplantation study 29 (ABMR;TCMR) / normal kidney tissue

Relative Expression (log2-ratio):4.0692053
Number of Samples:6 / 5
Experimental kidney transplantation study 29 (ABMR;TCMR)
Post-transplant renal allograft biopsies derived from kidney transplant patients with mixed antibody-mediated rejection (ABMR) and T cell-mediated rejection (TCMR).
Control normal kidney tissue
Histologically normal kidney tissue samples from patients undergoing native nephrectomy for renal carcinoma.