TOP TEN perturbations for 28921 (Homo sapiens)

Organism: Homo sapiens
Gene: 28921
Selected probe(set): 214768_x_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 28921 (214768_x_at) across 5339 perturbations tested by GENEVESTIGATOR:

multiple sclerosis study 10 (PP-MS) / cerebrospinal fluid cell sample (mixed neuropathologies)

Relative Expression (log2-ratio):5.9733477
Number of Samples:10 / 9
Experimental multiple sclerosis study 10 (PP-MS)
Cerebrospinal fluid (CSF) cell samples from patients with primary progressive multiple sclerosis (PP-MS). Active disease was defined by the presence of any of the following criteria during 6 month prior CSF collection: (1) one or more relapses, (2) change of 0.5 point or greater in EDSS (Expanded Disability Status Score), (3) change in the number and size of lesions visualized by gadolinium-enhanced MRI. Untreated MS patients did not receive any medication for at least 1 year before CSF sample collection.
Control cerebrospinal fluid cell sample (mixed neuropathologies)
Cerebrospinal fluid (CSF) cell samples from patients with different neuropathologies, other than multiple sclerosis.

osteoarthritis study 4 / rheumatoid arthritis study 2

Relative Expression (log2-ratio):-5.850835
Number of Samples:5 / 6
Experimental osteoarthritis study 4
Synovial tissue biopsy from a swollen knee of patients with osteoarthritis (active disease). Patients were naive to any immunosuppressive therapy, only some of them were receiving nonsteroidal antiinflammatory drugs (NSAID).
Control rheumatoid arthritis study 2
Synovial tissues from rheumatoid arthritis patients.

microcrystalline arthritis study 1 / rheumatoid arthritis study 2

Relative Expression (log2-ratio):-5.6994667
Number of Samples:4 / 6
Experimental microcrystalline arthritis study 1
Synovial tissue biopsy from a swollen knee of patients with microcristalline arthritis (active disease). The diagnosis of microcrystalline arthritis was based on the identification of urate or calcium pyrophosphate crystals in the synovial fluid. Patients were naive to any immunosuppressive therapy, only some of them were receiving nonsteroidal antiinflammatory drugs (NSAID).
Control rheumatoid arthritis study 2
Synovial tissues from rheumatoid arthritis patients.

seronegative arthritis study 1 / rheumatoid arthritis study 2

Relative Expression (log2-ratio):-5.463707
Number of Samples:4 / 6
Experimental seronegative arthritis study 1
Synovial tissue biopsy from a swollen knee of patients with seronegative arthritis (active disease). The diagnosis of seronegative arthritis was based on the presence of psoriasis or x-ray evidence of sacro-iliacal joint involvement. Patients were naive to any immunosuppressive therapy, only some of them were receiving nonsteroidal antiinflammatory drugs (NSAID).
Control rheumatoid arthritis study 2
Synovial tissues from rheumatoid arthritis patients.

HCV-related HCC study 1 / adjacent HCV-related liver tissue (LC)

Relative Expression (log2-ratio):-5.1343784
Number of Samples:5 / 4
Experimental HCV-related HCC study 1
Hepatitis C infection related human hepatocellular carcinoma sample.
Control adjacent HCV-related liver tissue (LC)
Histologically normal adjacent liver tissue of a patient with Hepatitis C infection related hepatocellular carcinoma. Patient with liver cirrhosis.

Rosacea study 1 (PhR) / normal skin tissue

Relative Expression (log2-ratio):4.673029
Number of Samples:12 / 20
Experimental Rosacea study 1 (PhR)
Skin biopsy samples from patients with phymatous rosacea (PhR), diagnosed in accordance with classification system of the American Rosacea Society. Skin biopsies were taken from nasolabial fold.
Control normal skin tissue
Normal skin biopsy samples from healthy individuals.

lung adenocarcinoma study 9 (metastase; lymph node) / lung adenocarcinoma study 9 (metastase; brain)

Relative Expression (log2-ratio):4.4298153
Number of Samples:3 / 6
Experimental lung adenocarcinoma study 9 (metastase; lymph node)
Metastatic tumor tissue obtained from the lymph node of patients with primary lung adenocarcinoma.
Control lung adenocarcinoma study 9 (metastase; brain)
Metastatic tumor tissue obtained from the brain of patients with primary lung adenocarcinoma.

collecting duct carcinoma study 1 / normal kidney tissue

Relative Expression (log2-ratio):4.396777
Number of Samples:2 / 3
Experimental collecting duct carcinoma study 1
Tumor tissue samples from the kidney of patients with collecting duct carcinoma (CDC).
Control normal kidney tissue
Normal adult kidney tissue samples.

osteoarthritis study 4 / lupus arthritis study 1

Relative Expression (log2-ratio):-4.3598843
Number of Samples:5 / 4
Experimental osteoarthritis study 4
Synovial tissue biopsy from a swollen knee of patients with osteoarthritis (active disease). Patients were naive to any immunosuppressive therapy, only some of them were receiving nonsteroidal antiinflammatory drugs (NSAID).
Control lupus arthritis study 1
Synovial tissue biopsy from a swollen knee of patients with systemic lupus erythematosus (SLE) associated arthritis (active disease). All patients with SLE met the American College of Rheumatology (ACR) revised classification criteria for SLE. Patients were naive to any immunosuppressive therapy, only some of them were receiving nonsteroidal antiinflammatory drugs (NSAID).

ulcerative colitis study 5 (baseline; non-responder) / normal colon mucosa tissue

Relative Expression (log2-ratio):4.346636
Number of Samples:16 / 6
Experimental ulcerative colitis study 5 (baseline; non-responder)
Colonic mucosal biopsies derived from ulcerative colitis patients who are non-responders to infliximab treatment. Biopsies were taken within a week prior to the first intravenous infusion of infliximab; the response to infliximab was assessed 4 to 6 weeks after the first infliximab treatment. The response was defined as a complete mucosal healing with a decrease of at least 3 points on the histological score for Crohn's disease (CDc) and as a decrease to a Mayo endoscopic subscore of 0 or 1 with a decrease to grade 0 or 1 on the histological score for ulcerative colitis (UC). More strict response criteria were used for Crohn's ileitis (CDi). More baseline information about the patients are available in the publication.
Control normal colon mucosa tissue
Colonic mucosal biopsy from control subject obtained at the endoscopy for polyps screening.