TOP TEN perturbations for NM_000019 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000019
Selected probe(set): 205412_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000019 (205412_at) across 5339 perturbations tested by GENEVESTIGATOR:

collecting duct carcinoma study 1 / normal kidney tissue

Relative Expression (log2-ratio):-3.9415026
Number of Samples:2 / 3
Experimental collecting duct carcinoma study 1
Tumor tissue samples from the kidney of patients with collecting duct carcinoma (CDC).
Control normal kidney tissue
Normal adult kidney tissue samples.

nephroblastoma study 2 / normal kidney tissue

Relative Expression (log2-ratio):-3.3703737
Number of Samples:4 / 3
Experimental nephroblastoma study 2
Tumor tissue samples from the kidney of patients with Wilms? tumor.
Control normal kidney tissue
Normal adult kidney tissue samples.

HCC study 20 (CDX; Hep-G2; ectopic) / HCC study 20 (PDX; ectopic)

Relative Expression (log2-ratio):-3.0501204
Number of Samples:3 / 11
Experimental HCC study 20 (CDX; Hep-G2; ectopic)
Tumor tissue biopsy samples from Hep-G2 cell line-derived xenograft (CDX) ectopically generated in SCID mice by injecting hepatocellular carcinoma cells subcutaneously. In order to establish ectopic models, cells were injected subcutaneously into the flank regions. The mice were euthanized after two weeks.
Control HCC study 20 (PDX; ectopic)
Tumor tissue biopsy samples from patient-derived xenograft (PDX) sample ectopically generated in SCID mice by injecting hepatocellular carcinoma cells subcutaneously. Donor tumor tissue was obtained intraoperatively during liver resection from three patients. All three patients had hepatocellular carcinoma confirmed by histology. In order to establish ectopic models, cells were injected subcutaneously into the flank regions. The mice were euthanized after two weeks.

oxyphilic adenoma study 1 / normal kidney tissue

Relative Expression (log2-ratio):2.91858
Number of Samples:4 / 2
Experimental oxyphilic adenoma study 1
Tumor tissue samples from the kidney of patients with oxyphilic adenoma (renal oncocytoma).
Control normal kidney tissue
Normal fetal kidney tissue samples.

hepatocyte (ESC) / HepaRG

Relative Expression (log2-ratio):-2.3976126
Number of Samples:8 / 12
Experimental hepatocyte (ESC)
Hepatocyte-like cells differentiated from embryonic stem cells (ESC)
Control HepaRG
Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code:

prostate cancer study 1 (meta.) / benign prostate tissue

Relative Expression (log2-ratio):-2.332654
Number of Samples:6 / 6
Experimental prostate cancer study 1 (meta.)
Metastatic prostate cancer samples.
Control benign prostate tissue
Benign prostate samples.

renal cell carcinoma study 6 (chromophobe type) / normal kidney tissue

Relative Expression (log2-ratio):2.2974424
Number of Samples:4 / 2
Experimental renal cell carcinoma study 6 (chromophobe type)
Tumor tissue samples from the kidney of patients with chromophobe renal cell carcinoma (cRCC).
Control normal kidney tissue
Normal fetal kidney tissue samples.

colorectal adenoma study 2 / normal colon tissue

Relative Expression (log2-ratio):-2.2128582
Number of Samples:5 / 6
Experimental colorectal adenoma study 2
Laser microdissected human adenoma sample.
Control normal colon tissue
Laser microdissected human colonic epithelial cells sample.

LPS study 4 (shRNA contr.) / mock treated / transduced MONO-MAC-6 cell sample

Relative Expression (log2-ratio):-2.160387
Number of Samples:2 / 2
Experimental LPS study 4 (shRNA contr.)
MONO-MAC-6 (MM6) cells were transduced with a control shRNA and then treated with 10 ng/ml lipopolysaccharide (LPS). ATC code:---
Control mock treated / transduced MONO-MAC-6 cell sample
MONO-MAC-6 (MM6) cells were transduced with a control shRNA and then mock treated.

clear cell renal cell carcinoma study 4 (stage 3) / normal kidney tissue

Relative Expression (log2-ratio):-2.1568966
Number of Samples:14 / 69
Experimental clear cell renal cell carcinoma study 4 (stage 3)
Primary tumor tissue from patients with stage 3 clear cell renal cell carcinoma (ccRCC).
Control normal kidney tissue
Normal kidney tissue samples obtained from healthy individuals.