TOP TEN perturbations for NM_000023 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000023
Selected probe(set): 210632_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000023 (210632_s_at) across 5339 perturbations tested by GENEVESTIGATOR:

TNF-?;TGF-? study 1 (3D) / untreated A549 cell sample (3D)

Relative Expression (log2-ratio):2.083891
Number of Samples:2 / 2
Experimental TNF-?;TGF-? study 1 (3D)
A549 cells were grown as 3D-culture/spheroids to 80% confluency and incubated with 10 ng/mL TNF and 2 ng/mL TGF two times each for 48 hours. Samples were taken 4 days after the treatment.
Control untreated A549 cell sample (3D)
A549 cells were grown as 3D-culture to 80% confluency and kept in culture for 4 days.

atopic dermatitis study 21 (lesional; dermis) / normal dermis tissue

Relative Expression (log2-ratio):-2.0626726
Number of Samples:5 / 6
Experimental atopic dermatitis study 21 (lesional; dermis)
Lesional dermal samples isolated from patient with moderate-to-severe atopic dermatitis by laser capture microdissection. Patients' cohort characteristics: 3 males and 2 females; age 27-59 years (mean age: 39.4 years); SCORing of Atopic Dermatitis index (SCORAD) ranging from 45-65; total IgE: 14-1821 kU/l; eosinophilic count: 1.4-11.8 %.
Control normal dermis tissue
Dermal samples isolated from healthy subjects by laser capture microdissection.

inclusion body myositis study 2 / normal quadriceps tissue

Relative Expression (log2-ratio):-2.0012646
Number of Samples:5 / 2
Experimental inclusion body myositis study 2
Quadriceps femoris biopsy muscle samples from patients with clinical diagnosis of inclusion body myositis (IBM).
Control normal quadriceps tissue
Quadriceps femoris biopsy muscle samples from control subjects.

kidney transplantation study 9 (late) / normal kidney transplant

Relative Expression (log2-ratio):1.7589846
Number of Samples:2 / 13
Experimental kidney transplantation study 9 (late)
Human renal allograft biopsies from deceased donors obtained 24 months after transplantation.
Control normal kidney transplant
Human renal allograft biopsies from deceased donors obtained at implantation prior to revascularization.

diphenylcyclopropenone study 1 (early) / placebo treated skin tissue

Relative Expression (log2-ratio):-1.7380724
Number of Samples:10 / 11
Experimental diphenylcyclopropenone study 1 (early)
Skin biopsy samples of healthy volunteers exposed to diphenylcyclopropenone (diphencyprone; DPCP) for 3 days. ATC code:---
Control placebo treated skin tissue
Skin biopsy samples of healthy volunteers exposed to placebo for 3 days.

ovarian tumor study 16 / normal ovarian surface epithelial cell sample

Relative Expression (log2-ratio):1.6341705
Number of Samples:3 / 5
Experimental ovarian tumor study 16
Human epithelial tumor cell samples from the ovary of patients with papillary serous carcinoma. Samples were derived by laser capture microdissection (LCM).
Control normal ovarian surface epithelial cell sample
Human epithelial cell samples from histopathological normal and non-cancerous ovary tissue.

diphenylcyclopropenone study 1 (late) / diphenylcyclopropenone study 1 (early)

Relative Expression (log2-ratio):1.4962854
Number of Samples:6 / 10
Experimental diphenylcyclopropenone study 1 (late)
Skin biopsy samples of healthy volunteers exposed to diphenylcyclopropenone (diphencyprone; DPCP) for 4 to 8 months. ATC code:---
Control diphenylcyclopropenone study 1 (early)
Skin biopsy samples of healthy volunteers exposed to diphenylcyclopropenone (diphencyprone; DPCP) for 3 days. ATC code:---

necrotizing myopathy study 1 / inclusion body myositis study 1

Relative Expression (log2-ratio):1.4182873
Number of Samples:3 / 5
Experimental necrotizing myopathy study 1
Biceps femoris biopsy muscle samples from patients with clinical diagnosis of necrotizing myopathy (NM).
Control inclusion body myositis study 1
Biceps femoris biopsy muscle samples from patients with clinical diagnosis of inclusion body myositis (IBM).

polymyositis study 1 / inclusion body myositis study 1

Relative Expression (log2-ratio):1.4158382
Number of Samples:5 / 5
Experimental polymyositis study 1
Biceps femoris biopsy muscle samples from patients with clinical diagnosis of polymyositis (PM).
Control inclusion body myositis study 1
Biceps femoris biopsy muscle samples from patients with clinical diagnosis of inclusion body myositis (IBM).

seronegative arthritis study 1 / rheumatoid arthritis study 2

Relative Expression (log2-ratio):1.4123716
Number of Samples:4 / 6
Experimental seronegative arthritis study 1
Synovial tissue biopsy from a swollen knee of patients with seronegative arthritis (active disease). The diagnosis of seronegative arthritis was based on the presence of psoriasis or x-ray evidence of sacro-iliacal joint involvement. Patients were naive to any immunosuppressive therapy, only some of them were receiving nonsteroidal antiinflammatory drugs (NSAID).
Control rheumatoid arthritis study 2
Synovial tissues from rheumatoid arthritis patients.