TOP TEN perturbations for NM_000063 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000063
Selected probe(set): 1554533_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000063 (1554533_at) across 5392 perturbations tested by GENEVESTIGATOR:

cutaneous sarcoidosis study 1 (lesional) / normal skin tissue

Relative Expression (log2-ratio):3.052781
Number of Samples:13 / 5
Experimental cutaneous sarcoidosis study 1 (lesional)
Lesional skin biopsies from patients with acute cutaneous sarcoidosis.
Control normal skin tissue
Skin biopsy samples from healthy control subjects.

hepatocyte (ESC) / HepaRG

Relative Expression (log2-ratio):-3.018958
Number of Samples:8 / 12
Experimental hepatocyte (ESC)
Hepatocyte-like cells differentiated from embryonic stem cells (ESC)
Control HepaRG
Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code:

4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone study 1 (7500 uM; HepaRG) / vehicle (DMSO) treated HepaRG cell sample

Relative Expression (log2-ratio):-2.5909824
Number of Samples:3 / 12
Experimental 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone study 1 (7500 uM; HepaRG)
HepaRG cells exposed to 7500 uM 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (dissolved in 0.5% v/v DMSO) for 72 hours. Cells were cultivated in DMSO-containing medium between days 13 - 19 to allow them to differentiate into hepatocyte-like cells and become fully functional. Chemical was added at day 19 of cultivation. Cells were treated with the IC10 determined by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test (number of replicates, n = 3). ATC code:---
Control vehicle (DMSO) treated HepaRG cell sample
HepaRG cells treated with vehicle (DMSO 0.5% v/v) for 72 hours. Firstly, cells were cultivated in DMSO-containing medium between days 13 - 19 to allow them to differentiate into hepatocyte-like cells and become fully functional. Then the vehicle was added.

hepatocyte (ESC) / Hep-G2

Relative Expression (log2-ratio):-2.5176096
Number of Samples:8 / 9
Experimental hepatocyte (ESC)
Hepatocyte-like cells differentiated from embryonic stem cells (ESC)
Control Hep-G2
Human primary cancer cell line derived from the liver of a patient with hepatocellular carcinoma. Synonyms:HEP-G2; Hep G2; HEP G2; HepG2; HEPG2 Cellosaurus code:

cutaneous sarcoidosis study 1 (lesional) / cutaneous sarcoidosis study 1 (non-lesional)

Relative Expression (log2-ratio):2.3452368
Number of Samples:13 / 9
Experimental cutaneous sarcoidosis study 1 (lesional)
Lesional skin biopsies from patients with acute cutaneous sarcoidosis.
Control cutaneous sarcoidosis study 1 (non-lesional)
Non-lesional skin biopsies from patients with acute cutaneous sarcoidosis.

Crohn's disease study 12 (inflamed) / normal colon epithelial cell sample

Relative Expression (log2-ratio):2.2589417
Number of Samples:3 / 3
Experimental Crohn's disease study 12 (inflamed)
Colon epithelial cells from macroscopically inflamed gut areas derived from patients with established Crohn's disease. Cells were obtained from microdissected epithelial fractions of surgically derived colon specimens. Histopathological examination of colon specimens displayed active lesions like erosions/ulcerations or crypt abscesses/cryptitis, and showed increased mononuclear infiltrates.
Control normal colon epithelial cell sample
Colon epithelial cells derived from microdissected epithelial fractions of normal colon tissue. Tissue was obtained during surgery from patients with tubulovillous adenoma of the colon or adenocarcinoma of the colon.

kidney transplantation study 9 (early) / normal kidney transplant

Relative Expression (log2-ratio):-2.2061834
Number of Samples:3 / 13
Experimental kidney transplantation study 9 (early)
Human renal allograft biopsies from deceased donors obtained 3 months after transplantation.
Control normal kidney transplant
Human renal allograft biopsies from deceased donors obtained at implantation prior to revascularization.

rapidly progressive glomerulonephritis; ANCA-associated vasculitis study 2 / minimal change disease study 2

Relative Expression (log2-ratio):1.9075818
Number of Samples:21 / 5
Experimental rapidly progressive glomerulonephritis; ANCA-associated vasculitis study 2
Tubulointerstitium tissue sample obtained by microdissection from kidney biopsy, from patients suffering from rapidly progressive glomerulonephritis and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Donors were positive for ANCA-antibody. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist..
Control minimal change disease study 2
Tubulointerstitium tissue sample obtained by microdissection from kidney biopsy, from patients suffering from minimal change disease. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist.

kidney transplantation study 9 (intermediate) / normal kidney transplant

Relative Expression (log2-ratio):-1.8327513
Number of Samples:7 / 13
Experimental kidney transplantation study 9 (intermediate)
Human renal allograft biopsies from deceased donors obtained 6 or 12 months after transplantation.
Control normal kidney transplant
Human renal allograft biopsies from deceased donors obtained at implantation prior to revascularization.

4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone study 1 (10000 uM; Hep-G2) / vehicle (PBS) treated Hep-G2 cell sample

Relative Expression (log2-ratio):-1.7631369
Number of Samples:3 / 6
Experimental 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone study 1 (10000 uM; Hep-G2)
Hep-G2 cells exposed to 10000 uM 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (dissolved in PBS) for 72 hours. Cells were exposed to the chemical when 80% confluence was reached. Cells were treated with the IC10 determined by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test (number of replicates, n = 3). ATC code:---
Control vehicle (PBS) treated Hep-G2 cell sample
Hep-G2 cells treated with vehicle (PBS) for 72 hours. Cells were exposed to the vehicle when 80% confluence was reached.