TOP TEN perturbations for NM_000065 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000065
Selected probe(set): 210168_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000065 (210168_at) across 5339 perturbations tested by GENEVESTIGATOR:

hepatocyte (ESC) / HepaRG

Relative Expression (log2-ratio):-7.0885134
Number of Samples:8 / 12
Experimental hepatocyte (ESC)
Hepatocyte-like cells differentiated from embryonic stem cells (ESC)
Control HepaRG
Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code:

Hep-G2 / HepaRG

Relative Expression (log2-ratio):-6.785019
Number of Samples:9 / 12
Experimental Hep-G2
Human primary cancer cell line derived from the liver of a patient with hepatocellular carcinoma. Synonyms:HEP-G2; Hep G2; HEP G2; HepG2; HEPG2 Cellosaurus code:
Control HepaRG
Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code:

HCC study 9 (HBV; HCV) / normal liver tissue

Relative Expression (log2-ratio):-5.5492115
Number of Samples:2 / 10
Experimental HCC study 9 (HBV; HCV)
Liver tissue biopsy sample from patients with Hepatitis B and C infection related hepatocellular carcinoma (HCC) after resection.
Control normal liver tissue
Normal, non-tumor liver tissue.

pancreatic cancer study 3 (ipmc) / normal pancreas tissue

Relative Expression (log2-ratio):-5.4034357
Number of Samples:6 / 6
Experimental pancreatic cancer study 3 (ipmc)
Intraductal papillary mucinous carcinoma from patients with pancreatic cancer.
Control normal pancreas tissue
Normal human pancreatic tissue.

pancreatic cancer study 3 (ipmn) / normal pancreas tissue

Relative Expression (log2-ratio):-5.3187284
Number of Samples:3 / 6
Experimental pancreatic cancer study 3 (ipmn)
Intraductal papillary mucinous neoplasm from patients with pancreatic cancer.
Control normal pancreas tissue
Normal human pancreatic tissue.

smoking study 31 / smoking study 30

Relative Expression (log2-ratio):4.901558
Number of Samples:9 / 18
Experimental smoking study 31
Small airway epithelial cells from healthy smokers, derived by fiberoptic bronchoscopy with conscious sedation. After mild sedation with meperidine and midazolam and routine anesthesia of the vocal cords and bronchial airways with topical lidocaine was achieved, the fiberoptic bronchoscope was positioned proximal to the opening of a desired lobar bronchus. A 2 mm diameter brush was advanced approximately 7 to 10 cm distal from the third order bronchial branch and the end of the brush was wedged at about the 10th to 12th generation branch of the right lower lobe. Small airway epithelial cells were collected by gently gliding the brush back and forth on the epithelium 5 to 10 times in 8 to 10 different locations in the same general area.
Control smoking study 30
Tracheal epithelial cells from healthy smokers. derived by tracheal brushing without conscious sedation. Tracheal epithelial cells were collected with a fiberoptic bronchoscope .Atropine 0.6 mg (IM) and 2.5 mL, 0.02% ipratropium was nebulized to decrease salivary and bronchial secretions. Topical anesthesia of the posterior pharynx and vocal cords was obtained by inhalation with 2 mL, 4% lidocaine followed by administering 1 spray of 20% benzocaine to the posterior pharynx. Unless there was a contraindication, the bronchoscope was introduced through the nostril after application of viscous 2% lidocaine with the patient sitting upright. Once the bronchoscope passed to the posterior pharynx, further topical anesthesia of the vocal cords and trachea was obtained with 1 mL aliquots of 1% lidocaine through the working port of the bronchoscope (maximum amount of lidocaine: 5 mg/kg body weight). After adequate topical anesthesia was obtained, a 2 mm cytology brush was advanced through the working channel of the bronchoscope and tracheal epithelial cells were obtained by gently gliding the brush back and forth 20 times on tracheal epithelium in at least five different locations.

pancreatic cancer study 3 (ipma) / normal pancreas tissue

Relative Expression (log2-ratio):-3.9379978
Number of Samples:6 / 6
Experimental pancreatic cancer study 3 (ipma)
Intraductal papillary mucinous adenoma from patients with pancreatic cancer.
Control normal pancreas tissue
Normal human pancreatic tissue.

male infertility study 1 (juvenile; Ad-) / normal testicular lobules tissue (mJS10)

Relative Expression (log2-ratio):3.9342165
Number of Samples:2 / 8
Experimental male infertility study 1 (juvenile; Ad-)
Human testicular lobules biopsy samples isolated from prepubescent patients with undescended testes. Testes of these children contained very low level of A-dark (Ad-) spermatogonial cells.
Control normal testicular lobules tissue (mJS10)
Biopsies of human testicular lobules isolated from fertile vasectomized adult men with normal spermatogenesis. Histological analysis classified samples as mJS10 (modified Johnsen score 10).

HCC study 9 (HBV; HCV) / HCC study 9 (HCV)

Relative Expression (log2-ratio):-3.9054346
Number of Samples:2 / 9
Experimental HCC study 9 (HBV; HCV)
Liver tissue biopsy sample from patients with Hepatitis B and C infection related hepatocellular carcinoma (HCC) after resection.
Control HCC study 9 (HCV)
Liver tissue biopsy sample from patients with Hepatitis C infection related hepatocellular carcinoma (HCC) after resection.

HCC study 3 (area A) / HCC study 3 (area C)

Relative Expression (log2-ratio):-3.706378
Number of Samples:13 / 24
Experimental HCC study 3 (area A)
Liver tissue biopsy sample from patients with HBV-associated HCC (hepatocellular carcinoma) after orthotopic liver transplantation (OLT) or partial hepatectomy. Tumorous sample was taken from the center of the tumor (area A). Patients were positive for hepatitis B surface antigen, antibody to hepatitis B core antigen and antibody to hepatitis B antigen and received antiviral treatment with nucleos(t)ide analogues prior to surgery.
Control HCC study 3 (area C)
Liver tissue biopsy sample from patients with HBV-associated HCC (hepatocellular carcinoma) after orthotopic liver transplantation (OLT) or partial hepatectomy. Non-tumorous sample was taken from the perilesional area of the tumor (area C). Patients were positive for hepatitis B surface antigen, antibody to hepatitis B core antigen and antibody to hepatitis B antigen and received antiviral treatment with nucleos(t)ide analogues prior to surgery.