TOP TEN perturbations for NM_000069 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000069
Selected probe(set): 217515_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000069 (217515_s_at) across 5392 perturbations tested by GENEVESTIGATOR:

basal cell carcinoma study 3 / normal epidermal keratinocytes

Relative Expression (log2-ratio):3.398075
Number of Samples:4 / 2
Experimental basal cell carcinoma study 3
Primary tumor tissue from the eyelid of patients with basal cell carcinoma (BCC).
Control normal epidermal keratinocytes
Normal human epidermal keratinocytes (NHEK) (Kurabo Ind., Ltd., Osaka, Japan) cultured in HuMedia-KB2 medium at 37?C in humidified air containing 5% CO2.

rheumatoid arthritis study 27 / normal synovial membrane tissue

Relative Expression (log2-ratio):-1.7165842
Number of Samples:16 / 7
Experimental rheumatoid arthritis study 27
Synovial membrane samples from end-stage rheumatoid arthritis patients undergoing surgery.
Control normal synovial membrane tissue
Synovial membrane samples obtained by fine-needle arthroscopy from healthy subjects.

ovarian tumor study 16 / normal ovarian surface epithelial cell sample

Relative Expression (log2-ratio):1.5899487
Number of Samples:3 / 5
Experimental ovarian tumor study 16
Human epithelial tumor cell samples from the ovary of patients with papillary serous carcinoma. Samples were derived by laser capture microdissection (LCM).
Control normal ovarian surface epithelial cell sample
Human epithelial cell samples from histopathological normal and non-cancerous ovary tissue.

necrotizing myopathy study 2 / inclusion body myositis study 2

Relative Expression (log2-ratio):1.2912703
Number of Samples:2 / 5
Experimental necrotizing myopathy study 2
Quadriceps femoris biopsy muscle samples from patients with clinical diagnosis of necrotizing myopathy (NM).
Control inclusion body myositis study 2
Quadriceps femoris biopsy muscle samples from patients with clinical diagnosis of inclusion body myositis (IBM).

exercise study 33 (OUT; fast twitch; post-exerc.) / exercise study 33 (YT; fast twitch; post-exerc.)

Relative Expression (log2-ratio):1.2606373
Number of Samples:3 / 6
Experimental exercise study 33 (OUT; fast twitch; post-exerc.)
Fast twitch myosin heavy chain muscle fibers (MHC) IIa were obtained from vastus lateralis muscle. Biopsies were taken from old untrained (OUT) women (85?1 years) 4 hours after the first resistance exercise. Fibers were separated under the light microscope and MHC isoform was determinated based on SDS-PAGE analysis. Exclusion criteria: acute/chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin or non-insulin-dependent diabetes, abnormal blood, or urine chemistries, arthritis, a history of neuromuscular problems, tobacco smoking. Individuals, that had ever completed any formal exercise programs or physical activity outside of their activities of daily living, were excluded as well.
Control exercise study 33 (YT; fast twitch; post-exerc.)
Fast twitch myosin heavy chain muscle fibers (MHC) IIa were obtained from vastus lateralis muscle. Biopsies were taken from young trained (YT) women (23?2 years old) 4 hours after the 36th (last) exercise session. Participants underwent 12 weeks of progressive resistance training including 36 training sessions (3 days/week) with three sets of 10 bilateral knee extensions at 70?75% of their one-repetition maximum (1 RM). Fibers were separated under the light microscope and MHC isoform was determinated based on SDS-PAGE analysis. Exclusion criteria: acute/chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin or non-insulin-dependent diabetes, abnormal blood, or urine chemistries, arthritis, a history of neuromuscular problems, tobacco smoking. Individuals, that had ever completed any formal exercise programs or physical activity outside of their activities of daily living, were excluded as well.

inclusion body myositis study 1 / normal biceps tissue

Relative Expression (log2-ratio):-1.2426119
Number of Samples:5 / 3
Experimental inclusion body myositis study 1
Biceps femoris biopsy muscle samples from patients with clinical diagnosis of inclusion body myositis (IBM).
Control normal biceps tissue
Biceps femoris biopsy muscle samples from control subjects.

stem cell differentiation study 41 (T3pi) / stem cell differentiation study 41 (hES-T3 EB)

Relative Expression (log2-ratio):1.197772
Number of Samples:2 / 2
Experimental stem cell differentiation study 41 (T3pi)
Sample of pancreatic islet-like cell clusters differentiated from human embryonic stem cells T3 with female karyotype.
Control stem cell differentiation study 41 (hES-T3 EB)
Sample of embryonic bodies (EB) differentiated from human embryonic stem cells T3 with female karyotype.

sepsis-ind. mult. organ failure study 1 / normal vastus lateralis muscle tissue

Relative Expression (log2-ratio):-1.1274452
Number of Samples:12 / 8
Experimental sepsis-ind. mult. organ failure study 1
Muscle biopsies from patients suffering from sepsis-induced multiple organ failure (MOF), treated in the intensive care unit. Biopsies were obtained from the lateral portion of the vastus lateralis muscle, 10-20 cm above the knee, using a Bergstroem biopsy needle after local anesthesia.
Control normal vastus lateralis muscle tissue
Muscle biopsies from control patients undergoing elective surgery. Biopsies were obtained from the lateral portion of the vastus lateralis muscle, 10-20 cm above the knee, using a Bergstroem biopsy needle just after sedation.

focal segmental glomerulosclerosis; minimal change disease study 4 / tumor adjacent glomerular tissue

Relative Expression (log2-ratio):-1.1246319
Number of Samples:6 / 3
Experimental focal segmental glomerulosclerosis; minimal change disease study 4
Glomeruli tissue sample obtained by microdissection from kidney biopsy, from patients suffering from focal segmental glomerulosclerosis and minimal change disease. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist.
Control tumor adjacent glomerular tissue
Normal renal glomerular tissue adjacent to tumor. Samples were obtained from tumor nephrectomies.

focal segmental glomerulosclerosis; minimal change disease study 1 / tumor adjacent glomerular tissue

Relative Expression (log2-ratio):-1.1075077
Number of Samples:6 / 3
Experimental focal segmental glomerulosclerosis; minimal change disease study 1
Glomeruli tissue sample obtained by microdissection from kidney biopsy, from patients suffering from focal segmental glomerulosclerosis and minimal change disease. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist.
Control tumor adjacent glomerular tissue
Normal renal glomerular tissue adjacent to tumor. Samples were obtained from tumor nephrectomies.