TOP TEN perturbations for NM_000071 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000071
Selected probe(set): 1553972_a_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000071 (1553972_a_at) across 5392 perturbations tested by GENEVESTIGATOR:

basal cell carcinoma study 3 / normal epidermal keratinocytes

Relative Expression (log2-ratio):-3.9859324
Number of Samples:4 / 2
Experimental basal cell carcinoma study 3
Primary tumor tissue from the eyelid of patients with basal cell carcinoma (BCC).
Control normal epidermal keratinocytes
Normal human epidermal keratinocytes (NHEK) (Kurabo Ind., Ltd., Osaka, Japan) cultured in HuMedia-KB2 medium at 37?C in humidified air containing 5% CO2.

colorectal cancer study 43 (metastase; brain) / colorectal cancer study 43 (metastase; lung)

Relative Expression (log2-ratio):3.3779716
Number of Samples:2 / 5
Experimental colorectal cancer study 43 (metastase; brain)
Metastatic tumor tissue obtained from the brain of patients with primary colorectal adenocarcinoma.
Control colorectal cancer study 43 (metastase; lung)
Metastatic tumor tissue obtained from the lung of patients with primary colon adenocarcinoma.

ovarian tumor study 28 (endometrioid carcinoma) / ovarian tumor study 28 (adenocarcinoma)

Relative Expression (log2-ratio):-3.3125982
Number of Samples:6 / 3
Experimental ovarian tumor study 28 (endometrioid carcinoma)
Primary tumor tissue sample obtained from the ovary of female patients with endometrioid carcinoma.
Control ovarian tumor study 28 (adenocarcinoma)
Primary tumor tissue sample obtained from the ovary of female patients with adenocarcinoma.

ovarian tumor study 28 (mucocarcinoid tumor) / ovarian tumor study 28 (adenocarcinoma)

Relative Expression (log2-ratio):-3.0204601
Number of Samples:7 / 3
Experimental ovarian tumor study 28 (mucocarcinoid tumor)
Primary tumor tissue sample obtained from the ovary of female patients with malignant mucocarcinoid tumor.
Control ovarian tumor study 28 (adenocarcinoma)
Primary tumor tissue sample obtained from the ovary of female patients with adenocarcinoma.

ovarian tumor study 16 / normal ovarian surface epithelial cell sample

Relative Expression (log2-ratio):3.013507
Number of Samples:3 / 5
Experimental ovarian tumor study 16
Human epithelial tumor cell samples from the ovary of patients with papillary serous carcinoma. Samples were derived by laser capture microdissection (LCM).
Control normal ovarian surface epithelial cell sample
Human epithelial cell samples from histopathological normal and non-cancerous ovary tissue.

engineered skin substitute study 2 (early) / engineered skin substitute study 1 (early)

Relative Expression (log2-ratio):-2.910306
Number of Samples:6 / 2
Experimental engineered skin substitute study 2 (early)
Human skin substitutes tissue samples collected after 3 and 7 days after transplantation to athymic mice.
Control engineered skin substitute study 1 (early)
Human skin substitutes tissue samples collected after 3 days in culture.

breast cancer study 3 / normal organelle sample

Relative Expression (log2-ratio):2.8592587
Number of Samples:17 / 12
Experimental breast cancer study 3
Breast basal tumor samples.
Control normal organelle sample
Normal organelle samples.

tunicamycin study 1 / vehicle (DMSO) treated B-cell-derived EBV-transformed lymphoblastoid cell sample

Relative Expression (log2-ratio):2.8558483
Number of Samples:60 / 60
Experimental tunicamycin study 1
B-cell-derived EBV-transformed lymphoblastoid cells (derived from Coriell cell repository) from unrelated individuals (grandparents in the HapMap CEPH-Utah pedigrees) were treated with 4 ug/ml tunicamycin for 8 hours. Tunicamycin is a mixture of homologous nucleoside antibiotics inhibiting polyprenol-P HexNAc-1-P family of enzymes. Tunicamycin blocks N-linked glycosylation (N-glycans) induce unfolded protein response (UPR) leading to accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER). ATC code:---
Control vehicle (DMSO) treated B-cell-derived EBV-transformed lymphoblastoid cell sample
B-cell-derived EBV-transformed lymphoblastoid cells (derived from Coriell cell repository) from unrelated individuals (grandparents in the HapMap CEPH-Utah pedigrees) treated with vehicle DMSO for 8 hours.

breast cancer study 3 / normal mammary gland tissue

Relative Expression (log2-ratio):2.817771
Number of Samples:17 / 7
Experimental breast cancer study 3
Breast basal tumor samples.
Control normal mammary gland tissue
Normal breast tissue samples.

oncolytic herpes simplex virus study 2 / mock infected peripheral nerve sheath tumor (S462) cell sample

Relative Expression (log2-ratio):-2.808361
Number of Samples:3 / 3
Experimental oncolytic herpes simplex virus study 2
Human malignant peripheral nerve sheath tumor (S462) cells infected with G207, an ICP34.5-deleted oncolytic herpes simplex virus (oHSV) for 6 hours.
Control mock infected peripheral nerve sheath tumor (S462) cell sample
Human malignant peripheral nerve sheath tumor (S462) cells mock infected for 6 hours.