TOP TEN perturbations for NM_000074 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000074
Selected probe(set): 207892_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000074 (207892_at) across 5339 perturbations tested by GENEVESTIGATOR:

Langerhans cell histiocytosis study 3 / normal tonsillar T-lymphocyte sample

Relative Expression (log2-ratio):-3.3109083
Number of Samples:10 / 4
Experimental Langerhans cell histiocytosis study 3
CD3+ T-lymphocyte samples isolated from Langerhans cell histiocytosis (LCH) lesions in bone (8 cases) or skin (2 cases). Patient with different clinical status were included in this study (unifocal, single system; multifocal, single system and multifocal, multisystem disease).
Control normal tonsillar T-lymphocyte sample
Normal tonsillar CD3+ T-lymphocytes were isolated from children who undergone elective tonsillectomy. The T-cells were isolated from presumably healthy tissue.

PMA study 3 (shRNA contr.) / mock treated / transduced Jurkat cell sample

Relative Expression (log2-ratio):2.8528557
Number of Samples:2 / 2
Experimental PMA study 3 (shRNA contr.)
Jurkat cells were transduced with a control shRNA and then treated with 10 ng/ml phorbol 12-myristate 13-acetate (PMA). ATC code:---
Control mock treated / transduced Jurkat cell sample
Jurkat cells were transduced with a control shRNA and then mock treated.

Treg activation study 1 (140min) / unstimulated regulatory T-cell sample

Relative Expression (log2-ratio):2.6662006
Number of Samples:2 / 2
Experimental Treg activation study 1 (140min)
Regulatory T-cells were stimulated for 140min with anti-CD3/anti-CD28/IL-2 (100U/ml). Treg were sorted as CD4+ CD25high cells from peripheral blood of healthy donors.
Control unstimulated regulatory T-cell sample
Unstimulated regulatory T-cell sample derived from sorted CD4+ CD25high cells from peripheral blood of healthy donors.

Treg activation study 1 (80min) / unstimulated regulatory T-cell sample

Relative Expression (log2-ratio):2.628973
Number of Samples:2 / 2
Experimental Treg activation study 1 (80min)
Regulatory T-cells were stimulated for 80min with anti-CD3/anti-CD28/IL-2 (100U/ml). Treg were sorted as CD4+ CD25high cells from peripheral blood of healthy donors.
Control unstimulated regulatory T-cell sample
Unstimulated regulatory T-cell sample derived from sorted CD4+ CD25high cells from peripheral blood of healthy donors.

Langerhans cell histiocytosis study 4 / normal tonsillar T-lymphocyte sample

Relative Expression (log2-ratio):-2.4524097
Number of Samples:7 / 4
Experimental Langerhans cell histiocytosis study 4
CD3+ T-lymphocyte samples isolated from peripheral blood of patients with Langerhans cell histiocytosis, prior to chemotherapy treatment. Patient with different clinical status were included in this study (unifocal, single system and multifocal, single system disease).
Control normal tonsillar T-lymphocyte sample
Normal tonsillar CD3+ T-lymphocytes were isolated from children who undergone elective tonsillectomy. The T-cells were isolated from presumably healthy tissue.

Treg activation study 1 (180min) / unstimulated regulatory T-cell sample

Relative Expression (log2-ratio):2.4488049
Number of Samples:2 / 2
Experimental Treg activation study 1 (180min)
Regulatory T-cells were stimulated for 180min with anti-CD3/anti-CD28/IL-2 (100U/ml). Treg were sorted as CD4+ CD25high cells from peripheral blood of healthy donors.
Control unstimulated regulatory T-cell sample
Unstimulated regulatory T-cell sample derived from sorted CD4+ CD25high cells from peripheral blood of healthy donors.

Treg activation study 1 (220min) / unstimulated regulatory T-cell sample

Relative Expression (log2-ratio):2.214014
Number of Samples:2 / 2
Experimental Treg activation study 1 (220min)
Regulatory T-cells were stimulated for 220min with anti-CD3/anti-CD28/IL-2 (100U/ml). Treg were sorted as CD4+ CD25high cells from peripheral blood of healthy donors.
Control unstimulated regulatory T-cell sample
Unstimulated regulatory T-cell sample derived from sorted CD4+ CD25high cells from peripheral blood of healthy donors.

Treg activation study 1 (320min) / unstimulated regulatory T-cell sample

Relative Expression (log2-ratio):2.1764536
Number of Samples:2 / 2
Experimental Treg activation study 1 (320min)
Regulatory T-cells were stimulated for 320min with anti-CD3/anti-CD28/IL-2 (100U/ml). Treg were sorted as CD4+ CD25high cells from peripheral blood of healthy donors.
Control unstimulated regulatory T-cell sample
Unstimulated regulatory T-cell sample derived from sorted CD4+ CD25high cells from peripheral blood of healthy donors.

Treg activation study 1 (260min) / unstimulated regulatory T-cell sample

Relative Expression (log2-ratio):2.0285892
Number of Samples:2 / 2
Experimental Treg activation study 1 (260min)
Regulatory T-cells were stimulated for 260min with anti-CD3/anti-CD28/IL-2 (100U/ml). Treg were sorted as CD4+ CD25high cells from peripheral blood of healthy donors.
Control unstimulated regulatory T-cell sample
Unstimulated regulatory T-cell sample derived from sorted CD4+ CD25high cells from peripheral blood of healthy donors.

Treg activation study 1 (360min) / unstimulated regulatory T-cell sample

Relative Expression (log2-ratio):1.8747482
Number of Samples:2 / 2
Experimental Treg activation study 1 (360min)
Regulatory T-cells were stimulated for 360min with anti-CD3/anti-CD28/IL-2 (100U/ml). Treg were sorted as CD4+ CD25high cells from peripheral blood of healthy donors.
Control unstimulated regulatory T-cell sample
Unstimulated regulatory T-cell sample derived from sorted CD4+ CD25high cells from peripheral blood of healthy donors.