TOP TEN perturbations for NM_000079 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000079
Selected probe(set): 206633_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000079 (206633_at) across 5392 perturbations tested by GENEVESTIGATOR:

leprosy study 1 (LL) / leprosy study 1 (BTL)

Relative Expression (log2-ratio):4.493166
Number of Samples:6 / 10
Experimental leprosy study 1 (LL)
Lesional skin biopsy samples from patients with lepromatous leprosy (LL).
Control leprosy study 1 (BTL)
Lesional skin biopsy samples from patients with borderline tuberculoid leprosy (BTL)

Merkel cell carcinoma study 3 (primary) / skin squamous cell carcinoma study 6

Relative Expression (log2-ratio):4.395832
Number of Samples:38 / 4
Experimental Merkel cell carcinoma study 3 (primary)
Primary tumor tissue from the skin of patients with Merkel cell carcinoma.
Control skin squamous cell carcinoma study 6
Primary tumor tissue from the skin of patients with squamous cell carcinoma (SCC).

Merkel cell carcinoma study 3 (primary) / normal skin tissue

Relative Expression (log2-ratio):4.304701
Number of Samples:38 / 64
Experimental Merkel cell carcinoma study 3 (primary)
Primary tumor tissue from the skin of patients with Merkel cell carcinoma.
Control normal skin tissue
Normal skin samples from healthy donors.

Merkel cell carcinoma study 3 (metastatic) / normal skin tissue

Relative Expression (log2-ratio):4.2812204
Number of Samples:22 / 64
Experimental Merkel cell carcinoma study 3 (metastatic)
Metastatic tumor tissue from different metastatic sites (skin, lymph node, parotid gland) of patients with Merkel cell carcinoma of the skin.
Control normal skin tissue
Normal skin samples from healthy donors.

Merkel cell carcinoma study 3 (primary) / basal cell carcinoma study 2

Relative Expression (log2-ratio):4.269761
Number of Samples:38 / 2
Experimental Merkel cell carcinoma study 3 (primary)
Primary tumor tissue from the skin of patients with Merkel cell carcinoma.
Control basal cell carcinoma study 2
Primary tumor tissue from the skin of patients with basal cell carcinoma (BCC).

leprosy study 1 (RRL) / leprosy study 1 (LL)

Relative Expression (log2-ratio):-4.1549053
Number of Samples:6 / 6
Experimental leprosy study 1 (RRL)
Lesional skin biopsy samples from patients with reversal reaction leprosy (RRL)
Control leprosy study 1 (LL)
Lesional skin biopsy samples from patients with lepromatous leprosy (LL).

inclusion body myositis study 1 / normal biceps tissue

Relative Expression (log2-ratio):3.933569
Number of Samples:5 / 3
Experimental inclusion body myositis study 1
Biceps femoris biopsy muscle samples from patients with clinical diagnosis of inclusion body myositis (IBM).
Control normal biceps tissue
Biceps femoris biopsy muscle samples from control subjects.

sepsis-ind. mult. organ failure study 1 / normal vastus lateralis muscle tissue

Relative Expression (log2-ratio):3.3805304
Number of Samples:12 / 8
Experimental sepsis-ind. mult. organ failure study 1
Muscle biopsies from patients suffering from sepsis-induced multiple organ failure (MOF), treated in the intensive care unit. Biopsies were obtained from the lateral portion of the vastus lateralis muscle, 10-20 cm above the knee, using a Bergstroem biopsy needle after local anesthesia.
Control normal vastus lateralis muscle tissue
Muscle biopsies from control patients undergoing elective surgery. Biopsies were obtained from the lateral portion of the vastus lateralis muscle, 10-20 cm above the knee, using a Bergstroem biopsy needle just after sedation.

small cell lung cancer study 4 (2. gen. PDX) / small cell lung cancer study 4 (2. gen. CDX)

Relative Expression (log2-ratio):3.2476301
Number of Samples:4 / 12
Experimental small cell lung cancer study 4 (2. gen. PDX)
Xenografts (secondary) tumor tissue samples derived from a PDX-derived cell lines. A patient derived xenograft (PDX)-derived cell lines were grown under conventional tissue culture conditions for six months and then reimplanted to generate secondary xenografts (2. gen.).
Control small cell lung cancer study 4 (2. gen. CDX)
Xenografts (secondary) tumor tissue samples derived from a CDX-derived cell lines. A cell line derived xenograft (CDX)-derived cell lines were grown under conventional tissue culture conditions for six months and then reimplanted to generate secondary xenografts (2. gen.).

necrotizing myopathy study 1 / normal biceps tissue

Relative Expression (log2-ratio):2.9982538
Number of Samples:3 / 3
Experimental necrotizing myopathy study 1
Biceps femoris biopsy muscle samples from patients with clinical diagnosis of necrotizing myopathy (NM).
Control normal biceps tissue
Biceps femoris biopsy muscle samples from control subjects.