TOP TEN perturbations for NM_000088 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000088
Selected probe(set): 202310_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000088 (202310_s_at) across 5339 perturbations tested by GENEVESTIGATOR:

hepatocyte (ESC) / Hep-G2

Relative Expression (log2-ratio):8.51365
Number of Samples:8 / 9
Experimental hepatocyte (ESC)
Hepatocyte-like cells differentiated from embryonic stem cells (ESC)
Control Hep-G2
Human primary cancer cell line derived from the liver of a patient with hepatocellular carcinoma. Synonyms:HEP-G2; Hep G2; HEP G2; HepG2; HEPG2 Cellosaurus code:

glioma study 16 (LN-229) / normal astrocyte sample

Relative Expression (log2-ratio):-7.5033655
Number of Samples:2 / 3
Experimental glioma study 16 (LN-229)
Human glioma cell line LN229 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37?C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

hepatocyte (ESC) / HepaRG

Relative Expression (log2-ratio):7.2799234
Number of Samples:8 / 12
Experimental hepatocyte (ESC)
Hepatocyte-like cells differentiated from embryonic stem cells (ESC)
Control HepaRG
Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code:

renal cell carcinoma study 6 (chromophobe type) / normal kidney tissue

Relative Expression (log2-ratio):-6.2203655
Number of Samples:4 / 2
Experimental renal cell carcinoma study 6 (chromophobe type)
Tumor tissue samples from the kidney of patients with chromophobe renal cell carcinoma (cRCC).
Control normal kidney tissue
Normal fetal kidney tissue samples.

glioma study 16 (LN-18) / normal astrocyte sample

Relative Expression (log2-ratio):-6.11384
Number of Samples:2 / 3
Experimental glioma study 16 (LN-18)
Human glioma cell line LN018 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

B-CLL study 11 (DMSO) / vehicle (DMSO) treated normal B-cell sample

Relative Expression (log2-ratio):-5.9371653
Number of Samples:4 / 4
Experimental B-CLL study 11 (DMSO)
Peripheral blood mononuclear cells (PBMCs) obtained from chronic lymphocytic leukemia (CLL) patients and in vitro treated with vehicle (DMSO) for 4 hours. PBMCs? samples contained 90% CD19+ CD5+ B lineage CLL cells (B-CLL). Inclusion criteria: untreated CLL patients or at least 1 month after chemotherapy. Exclusion criteria: patients with active infections or other serious medical conditions or with white blood cell (WBC) counts of 15,000/l.
Control vehicle (DMSO) treated normal B-cell sample
MACS purified resting B-cells from healthy donor peripheral blood treated with vehicle (DMSO) for 4 hours.

oxyphilic adenoma study 1 / normal kidney tissue

Relative Expression (log2-ratio):-5.637784
Number of Samples:4 / 2
Experimental oxyphilic adenoma study 1
Tumor tissue samples from the kidney of patients with oxyphilic adenoma (renal oncocytoma).
Control normal kidney tissue
Normal fetal kidney tissue samples.

SKVCR2.0 / SK-OV-3

Relative Expression (log2-ratio):5.631522
Number of Samples:2 / 2
Experimental SKVCR2.0
Human metastatic cancer cell line derived from the ascites of a patent with adenocarcinoma of the ovary. Vincristine-resistant derivative of the ovarian adenocarcinoma cell line SKOV3 capable of growing in media with 2.0 ?g/ml vincristine drug. Parental cell line:: SK-OV-3 Synonyms:SKVCR 2.0; SK VCR 2 Cellosaurus code:
Control SK-OV-3
Human metastatic cancer cell line derived from the ascites of a patient with adenocarcinoma of the ovary. Synonyms:SKOV-3; SK.OV.3; SKOV3; SKO3 Cellosaurus code:

colorectal cancer study 11 (immediate) / colorectal cancer study 10

Relative Expression (log2-ratio):-5.514428
Number of Samples:7 / 7
Experimental colorectal cancer study 11 (immediate)
Primary cells of human colorectal adenocarcinoma prepared directly from snap frozen tumor tissue samples after resection and cultivated for 24 hours.
Control colorectal cancer study 10
Human primary colorectal adenocarcinoma tissue samples after resection.

colorectal cancer study 11 (late) / colorectal cancer study 10

Relative Expression (log2-ratio):-5.3977795
Number of Samples:7 / 7
Experimental colorectal cancer study 11 (late)
Primary cells of human colorectal adenocarcinoma prepared directly from snap frozen tumor tissue samples after resection and cultivated for 72 hours.
Control colorectal cancer study 10
Human primary colorectal adenocarcinoma tissue samples after resection.