TOP TEN perturbations for NM_000089 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000089
Selected probe(set): 202403_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000089 (202403_s_at) across 5339 perturbations tested by GENEVESTIGATOR:

glioma study 16 (LN-229) / normal astrocyte sample

Relative Expression (log2-ratio):-8.856924
Number of Samples:2 / 3
Experimental glioma study 16 (LN-229)
Human glioma cell line LN229 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37?C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

hepatocyte (ESC) / HepaRG

Relative Expression (log2-ratio):8.320369
Number of Samples:8 / 12
Experimental hepatocyte (ESC)
Hepatocyte-like cells differentiated from embryonic stem cells (ESC)
Control HepaRG
Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code:

hepatocyte (ESC) / Hep-G2

Relative Expression (log2-ratio):8.132345
Number of Samples:8 / 9
Experimental hepatocyte (ESC)
Hepatocyte-like cells differentiated from embryonic stem cells (ESC)
Control Hep-G2
Human primary cancer cell line derived from the liver of a patient with hepatocellular carcinoma. Synonyms:HEP-G2; Hep G2; HEP G2; HepG2; HEPG2 Cellosaurus code:

glioma study 16 (LN-18) / normal astrocyte sample

Relative Expression (log2-ratio):-6.6403217
Number of Samples:2 / 3
Experimental glioma study 16 (LN-18)
Human glioma cell line LN018 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

SKVCR2.0 / SK-OV-3

Relative Expression (log2-ratio):5.9880695
Number of Samples:2 / 2
Experimental SKVCR2.0
Human metastatic cancer cell line derived from the ascites of a patent with adenocarcinoma of the ovary. Vincristine-resistant derivative of the ovarian adenocarcinoma cell line SKOV3 capable of growing in media with 2.0 ?g/ml vincristine drug. Parental cell line:: SK-OV-3 Synonyms:SKVCR 2.0; SK VCR 2 Cellosaurus code:
Control SK-OV-3
Human metastatic cancer cell line derived from the ascites of a patient with adenocarcinoma of the ovary. Synonyms:SKOV-3; SK.OV.3; SKOV3; SKO3 Cellosaurus code:

renal cell carcinoma study 6 (chromophobe type) / normal kidney tissue

Relative Expression (log2-ratio):-5.4746637
Number of Samples:4 / 2
Experimental renal cell carcinoma study 6 (chromophobe type)
Tumor tissue samples from the kidney of patients with chromophobe renal cell carcinoma (cRCC).
Control normal kidney tissue
Normal fetal kidney tissue samples.

colorectal cancer study 11 (immediate) / colorectal cancer study 10

Relative Expression (log2-ratio):-5.3888807
Number of Samples:7 / 7
Experimental colorectal cancer study 11 (immediate)
Primary cells of human colorectal adenocarcinoma prepared directly from snap frozen tumor tissue samples after resection and cultivated for 24 hours.
Control colorectal cancer study 10
Human primary colorectal adenocarcinoma tissue samples after resection.

basal cell carcinoma study 3 / normal epidermal keratinocytes

Relative Expression (log2-ratio):5.326915
Number of Samples:4 / 2
Experimental basal cell carcinoma study 3
Primary tumor tissue from the eyelid of patients with basal cell carcinoma (BCC).
Control normal epidermal keratinocytes
Normal human epidermal keratinocytes (NHEK) (Kurabo Ind., Ltd., Osaka, Japan) cultured in HuMedia-KB2 medium at 37?C in humidified air containing 5% CO2.

breast cancer study 24 / breast cancer study 22

Relative Expression (log2-ratio):5.0292397
Number of Samples:10 / 10
Experimental breast cancer study 24
Freshly purified CD4+ tumor-infiltrating T cells derived from female primary invasive breast ductal carcinoma. For individual patient characteristics see detailed sample information. The initial tissue dissociation was performed mechanically, without enzymatic digestion.
Control breast cancer study 22
Freshly purified CD4+ T cells from peripheral blood of female donors with primary invasive breast ductal carcinoma. For individual patient characteristics see detailed sample information.

colorectal cancer study 11 (late) / colorectal cancer study 10

Relative Expression (log2-ratio):-4.8505793
Number of Samples:7 / 7
Experimental colorectal cancer study 11 (late)
Primary cells of human colorectal adenocarcinoma prepared directly from snap frozen tumor tissue samples after resection and cultivated for 72 hours.
Control colorectal cancer study 10
Human primary colorectal adenocarcinoma tissue samples after resection.