TOP TEN perturbations for NM_000112 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000112
Selected probe(set): 224959_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000112 (224959_at) across 5392 perturbations tested by GENEVESTIGATOR:

ulcerative colitis study 5 (baseline; non-responder) / normal colon mucosa tissue

Relative Expression (log2-ratio):-5.025343
Number of Samples:16 / 6
Experimental ulcerative colitis study 5 (baseline; non-responder)
Colonic mucosal biopsies derived from ulcerative colitis patients who are non-responders to infliximab treatment. Biopsies were taken within a week prior to the first intravenous infusion of infliximab; the response to infliximab was assessed 4 to 6 weeks after the first infliximab treatment. The response was defined as a complete mucosal healing with a decrease of at least 3 points on the histological score for Crohn's disease (CDc) and as a decrease to a Mayo endoscopic subscore of 0 or 1 with a decrease to grade 0 or 1 on the histological score for ulcerative colitis (UC). More strict response criteria were used for Crohn's ileitis (CDi). More baseline information about the patients are available in the publication.
Control normal colon mucosa tissue
Colonic mucosal biopsy from control subject obtained at the endoscopy for polyps screening.

colorectal adenoma study 4 (large) / adjacent colon mucosa tissue

Relative Expression (log2-ratio):-4.6626654
Number of Samples:3 / 7
Experimental colorectal adenoma study 4 (large)
Rectum biopsies of colorectal adenomas (size: 3cm - 4cm).
Control adjacent colon mucosa tissue
Biopsies of rectum mucosa from adjacent tumor tissue.

colorectal cancer study 33 (carcinoma; cecum) / normal cecum tissue

Relative Expression (log2-ratio):-4.14909
Number of Samples:4 / 2
Experimental colorectal cancer study 33 (carcinoma; cecum)
Primary tumor samples derived from the cecum of patients with carcinoma.
Control normal cecum tissue
Normal cecal tissue samples.

colorectal cancer study 13 (tvvad) / normal colon tissue

Relative Expression (log2-ratio):-4.1458044
Number of Samples:3 / 3
Experimental colorectal cancer study 13 (tvvad)
Colon biopsies derived from patients with low grade tubulovillous/villous adenoma.
Control normal colon tissue
Colon biopsies derived from healthy controls.

hepatocyte (ESC) / Hep-G2

Relative Expression (log2-ratio):4.111787
Number of Samples:8 / 9
Experimental hepatocyte (ESC)
Hepatocyte-like cells differentiated from embryonic stem cells (ESC)
Control Hep-G2
Human primary cancer cell line derived from the liver of a patient with hepatocellular carcinoma. Synonyms:HEP-G2; Hep G2; HEP G2; HepG2; HEPG2 Cellosaurus code:

colorectal adenoma study 7 (colonic mucosa) / normal colon mucosa sample

Relative Expression (log2-ratio):-4.1097393
Number of Samples:5 / 5
Experimental colorectal adenoma study 7 (colonic mucosa)
Colonic mucosa samples obtained by laser capture microdissection (LCM) from patients with colorectal adenoma.
Control normal colon mucosa sample
Histopathological normal colon mucosa sample obtained by laser capture microdissection (LCM) from the distant normal colon of patients with colorectal cancer.

colorectal adenoma study 1 (small) / adjacent colon mucosa tissue

Relative Expression (log2-ratio):-4.104724
Number of Samples:3 / 4
Experimental colorectal adenoma study 1 (small)
Ascending colon biopsies of colorectal adenomas (size: 1cm - 2cm).
Control adjacent colon mucosa tissue
Biopsies of ascending colon mucosa from adjacent tumor tissue.

influenza virus study 9 (A/pH1N1) / influenza virus study 4 (A/H1N1)

Relative Expression (log2-ratio):4.08545
Number of Samples:3 / 3
Experimental influenza virus study 9 (A/pH1N1)
Human carcinoma cell line A549 infected with influenza A virus subtype [A/Singapore/478/2009 (pH1N1)]. Samples were taken 10 hours post-infection.
Control influenza virus study 4 (A/H1N1)
Human carcinoma cell line A549 infected with influenza A virus subtype A/WSN/33 (H1N1). Samples were taken 10 hours post-infection.

brefeldin A study 1 (0.5ug/ml; p53HCT116) / untreated p53HCT116 cell sample

Relative Expression (log2-ratio):3.9851189
Number of Samples:2 / 3
Experimental brefeldin A study 1 (0.5ug/ml; p53HCT116)
Derived human colon carcinoma cell line p53HCT116 with knockout gene for p53 was treated with 0.5 ug/ml brefeldin-A for 24 hours in McCOYs 5A medium supplemented with 10% heat inactivated FBS. ATC code:---
Control untreated p53HCT116 cell sample
Derived human colon carcinoma cell line p53HCT116 with knockout gene for p53 was grown in McCOYs 5A medium supplemented with 10% heat inactivated FBS.

ulcerative colitis study 5 (baseline; responder) / normal colon mucosa tissue

Relative Expression (log2-ratio):-3.979598
Number of Samples:8 / 6
Experimental ulcerative colitis study 5 (baseline; responder)
Colonic mucosal biopsies derived from ulcerative colitis patients who are responders to infliximab treatment. Biopsies were taken within a week prior to the first intravenous infusion of infliximab; the response to infliximab was assessed 4 to 6 weeks after the first infliximab treatment. The response was defined as a complete mucosal healing with a decrease of at least 3 points on the histological score for Crohn's disease (CDc) and as a decrease to a Mayo endoscopic subscore of 0 or 1 with a decrease to grade 0 or 1 on the histological score for ulcerative colitis (UC). More strict response criteria were used for Crohn's ileitis (CDi). More baseline information about the patients are available in the publication.
Control normal colon mucosa tissue
Colonic mucosal biopsy from control subject obtained at the endoscopy for polyps screening.