TOP TEN perturbations for NM_000121 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000121
Selected probe(set): 396_f_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000121 (396_f_at) across 5339 perturbations tested by GENEVESTIGATOR:

atopic dermatitis study 21 (lesional; whole skin) / normal skin tissue

Relative Expression (log2-ratio):-3.022996
Number of Samples:5 / 6
Experimental atopic dermatitis study 21 (lesional; whole skin)
Lesional full thickness skin samples isolated from patient with moderate-to-severe atopic dermatitis by laser capture microdissection. Patients' cohort characteristics: 3 males and 2 females; age 27-59 years (mean age: 39.4 years); SCORing of Atopic Dermatitis index (SCORAD) ranging from 45-65; total IgE: 14-1821 kU/l; eosinophilic count: 1.4-11.8 %.
Control normal skin tissue
Full thickness skin samples isolated from healthy subjects by laser capture microdissection.

atopic dermatitis study 21 (non-lesional; whole skin) / normal skin tissue

Relative Expression (log2-ratio):-2.6992245
Number of Samples:5 / 6
Experimental atopic dermatitis study 21 (non-lesional; whole skin)
Non-lesional full thickness skin samples isolated from patient with moderate-to-severe atopic dermatitis by laser capture microdissection. Patients' cohort characteristics: 3 males and 2 females; age 27-59 years (mean age: 39.4 years); SCORing of Atopic Dermatitis index (SCORAD) ranging from 45-65; total IgE: 14-1821 kU/l; eosinophilic count: 1.4-11.8 %.
Control normal skin tissue
Full thickness skin samples isolated from healthy subjects by laser capture microdissection.

CEBP overexpr. study 1 / empty vector transfected myometrium myocyte sample

Relative Expression (log2-ratio):2.6296492
Number of Samples:3 / 3
Experimental CEBP overexpr. study 1
Primary myometrium myocytes transfected with unspecified CEBP (CCAAT/Enhancer Binding Protein) and harvested after 48 hours. Term myocytes from lower uterine segment were obtained pre-labour from elective caesarean section performed at or after 39 weeks in uncomplicated pregnancies with spontaneously established labor. Indication for caesarean section were cephalopelvic disproportion and risk of fetal hypoxia. None of the patients had received uterotonics. All biopsies were taken by the same surgeon.
Control empty vector transfected myometrium myocyte sample
Primary myometrium myocytes transfected with empty vector PSG5 and harvested after 48 hours. Term myocytes from lower uterine segment were obtained pre-labour from elective caesarean section performed at or after 39 weeks in uncomplicated pregnancies with spontaneously established labor. Indication for caesarean section were cephalopelvic disproportion and risk of fetal hypoxia. None of the patients had received uterotonics. All biopsies were taken by the same surgeon.

small cell lung cancer study 4 (XCL from CDX) / small cell lung cancer study 4 (cell line)

Relative Expression (log2-ratio):-2.1303034
Number of Samples:11 / 4
Experimental small cell lung cancer study 4 (XCL from CDX)
Xenograft-derived cell lines (XCL) established from a small cell lung carcinoma (SCLC) publicly available cell lines derived xenografts (CDX derived cell lines). Xenografts were grown in the flanks of a nude mice. Obtained cells were cultivated under conventional tissue culture conditions.
Control small cell lung cancer study 4 (cell line)
Various small cell lung cancer (SCLC) publicly available cell lines samples.

ovarian tumor study 11 (low grade) / normal ovarian surface epithelial cell sample

Relative Expression (log2-ratio):-2.0635157
Number of Samples:11 / 6
Experimental ovarian tumor study 11 (low grade)
Human microdissected tumor cells from the ovary of patients with low grade serous carcinoma.
Control normal ovarian surface epithelial cell sample
Human microdissected ovarian surface epithelial cell sample from the ovary of healthy individuals.

hepatocyte (ESC) / HepaRG

Relative Expression (log2-ratio):-2.0346441
Number of Samples:8 / 12
Experimental hepatocyte (ESC)
Hepatocyte-like cells differentiated from embryonic stem cells (ESC)
Control HepaRG
Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code:

medulloblastoma study 2 / non-tumor brain tissue

Relative Expression (log2-ratio):1.9847136
Number of Samples:4 / 9
Experimental medulloblastoma study 2
Primary tumor tissue sample from the infratentorial brain of pediatric patients with large-cell anaplastic medulloblastoma.
Control non-tumor brain tissue
Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor.

glioma study 16 (glioblastoma) / normal brain tissue

Relative Expression (log2-ratio):-1.6690779
Number of Samples:12 / 2
Experimental glioma study 16 (glioblastoma)
Primary glioma tissues obtained from the operating room. Tumors were diagnosed and graded according to the current WHO classification (grade IV).
Control normal brain tissue
Normal brain tissue sample from healthy donors.

ovarian tumor study 17 / normal ovarian surface epithelial cell sample

Relative Expression (log2-ratio):-1.6536369
Number of Samples:9 / 10
Experimental ovarian tumor study 17
Human epithelial tumor cell samples from the ovary of patients with primary clear cell carcinoma. Samples were derived by laser capture microdissection (LCM).
Control normal ovarian surface epithelial cell sample
Human epithelial cell samples from histopathological normal and non-cancerous ovary tissue from donors with non-cancerous, benign gynecological diseases.

glioma study 16 (astrocytoma) / normal brain tissue

Relative Expression (log2-ratio):-1.6198063
Number of Samples:8 / 2
Experimental glioma study 16 (astrocytoma)
Primary astrocytoma tissues obtained from the operating room. Tumors were diagnosed and graded according to the current WHO classification (grade III-IV).
Control normal brain tissue
Normal brain tissue sample from healthy donors.