TOP TEN perturbations for NM_000125 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000125
Selected probe(set): 205225_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000125 (205225_at) across 5339 perturbations tested by GENEVESTIGATOR:

breast cancer study 40 (metastase; ovary) / ovarian tumor study 28 (carcinosarcoma)

Relative Expression (log2-ratio):5.253602
Number of Samples:44 / 2
Experimental breast cancer study 40 (metastase; ovary)
Metastatic tumor tissue obtained from the ovary of female patients with primary breast cancer.
Control ovarian tumor study 28 (carcinosarcoma)
Primary tumor tissue sample obtained from the ovary of female patients with carcinosarcoma.

HCC study 9 (HBV; HCV) / normal liver tissue

Relative Expression (log2-ratio):-4.9916115
Number of Samples:2 / 10
Experimental HCC study 9 (HBV; HCV)
Liver tissue biopsy sample from patients with Hepatitis B and C infection related hepatocellular carcinoma (HCC) after resection.
Control normal liver tissue
Normal, non-tumor liver tissue.

prostate cancer study 8 (p. canc) / prostate cancer study 8 (ptasc)

Relative Expression (log2-ratio):-4.8951454
Number of Samples:3 / 2
Experimental prostate cancer study 8 (p. canc)
CD26+ FACS sorted prostate neoplasm cell (p. canc) samples from patients with primary prostate cancer collected after radical prostatectomy.
Control prostate cancer study 8 (ptasc)
CD90+ FACS sorted prostate tumor-associated stromal cell (ptasc) samples from patients with primary prostate cancer collected after radical prostatectomy.

basal cell carcinoma study 3 / normal epidermal keratinocytes

Relative Expression (log2-ratio):4.5168467
Number of Samples:4 / 2
Experimental basal cell carcinoma study 3
Primary tumor tissue from the eyelid of patients with basal cell carcinoma (BCC).
Control normal epidermal keratinocytes
Normal human epidermal keratinocytes (NHEK) (Kurabo Ind., Ltd., Osaka, Japan) cultured in HuMedia-KB2 medium at 37?C in humidified air containing 5% CO2.

breast cancer study 40 (metastase; ovary) / ovarian tumor study 28 (adenocarcinoma)

Relative Expression (log2-ratio):4.506853
Number of Samples:44 / 3
Experimental breast cancer study 40 (metastase; ovary)
Metastatic tumor tissue obtained from the ovary of female patients with primary breast cancer.
Control ovarian tumor study 28 (adenocarcinoma)
Primary tumor tissue sample obtained from the ovary of female patients with adenocarcinoma.

breast cancer study 40 (metastase; ovary) / ovarian tumor study 28 (clear cell adenocarcinoma)

Relative Expression (log2-ratio):4.346734
Number of Samples:44 / 6
Experimental breast cancer study 40 (metastase; ovary)
Metastatic tumor tissue obtained from the ovary of female patients with primary breast cancer.
Control ovarian tumor study 28 (clear cell adenocarcinoma)
Primary tumor tissue sample obtained from the ovary of female patients with clear cell adenocarcinoma.

pancreatic islet study 3 (expanded; PPRF) / normal pancreatic islet sample

Relative Expression (log2-ratio):-4.2975254
Number of Samples:2 / 7
Experimental pancreatic islet study 3 (expanded; PPRF)
Human pancreatic islets were isolated from a cadaveric donor. The population was 70% pure in mature islets, which was determined by dithizone staining. Islets cells were expanded according to Pharmaceutical Production Research Facility Protocol (PPRF) for 6 weeks. Expansion phase: Approximately 2,500 islet equivalents were seeded onto 75-cm2 fibronectin-coated tissue culture-treated flasks in a proprietary serum-free medium (PPRF medium). The serum-free PPRF medium was supplemented with 30% serum-free mesenchymal-conditioned medium. When the cell migration resulted in the formation of large-size colonies, the cells were harvested by trypsinization and replated into new tissue culture flasks. Once the cells reached near confluence (80?90%) in monolayer, they were trypsinized, counted, and subcultured at a density of 5,000 cells per cm2. Thereafter, cells were serially passaged using the same protocol.
Control normal pancreatic islet sample
Pancreatic islets were obtained from seven donors aged between 37 and 70 years and body mass index between 22 and 27. Functional islets were cultured in CMRL 1066 supplemented with 10% FCS, 1% glutamine, 5.6 mM glucose, 1 mM HEPES, 110 U/ml penicillin, and 110 g/ml streptomycin for 7 days or immediately processed after isolation.

HCC study 9 (HBV) / normal liver tissue

Relative Expression (log2-ratio):-4.273555
Number of Samples:10 / 10
Experimental HCC study 9 (HBV)
Liver tissue biopsy sample from patients with Hepatitis B infection related hepatocellular carcinoma (HCC) after resection.
Control normal liver tissue
Normal, non-tumor liver tissue.

breast cancer study 3 / normal mammary gland tissue

Relative Expression (log2-ratio):-4.141773
Number of Samples:17 / 7
Experimental breast cancer study 3
Breast basal tumor samples.
Control normal mammary gland tissue
Normal breast tissue samples.

ovarian tumor study 28 (serous cystadenocarcinoma) / ovarian tumor study 28 (carcinosarcoma)

Relative Expression (log2-ratio):4.082656
Number of Samples:71 / 2
Experimental ovarian tumor study 28 (serous cystadenocarcinoma)
Primary tumor tissue sample obtained from the ovary of female patients with malignant serous cystadenocarcinoma.
Control ovarian tumor study 28 (carcinosarcoma)
Primary tumor tissue sample obtained from the ovary of female patients with carcinosarcoma.