TOP TEN perturbations for NM_000139 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000139
Selected probe(set): 207496_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000139 (207496_at) across 5392 perturbations tested by GENEVESTIGATOR:

stem cell differentiation study 50 (MYB shRNA; ASC; proerythroblast) / stem cell differentiation study 50 (mock shRNA; ASC; proerythroblast)

Relative Expression (log2-ratio):3.3408523
Number of Samples:4 / 4
Experimental stem cell differentiation study 50 (MYB shRNA; ASC; proerythroblast)
Proerythroblast differentiated from MYB shRNA transduced hematopoietic stem/progenitor cells (CD34+). CD34+ hematopoietic stem/progenitor cells (HSC) were transduced with lentivirus expressing shRNA targeting MYB gene with following differentiation to the erythroid lineage. HSCs were obtained from magnetically sorted G-CSF mobilized peripheral blood mononuclear cells of healthy donors. Cells were expanded in StemSpan SFEM medium supplied with Flt-3 ligand (100 ng/ml), SCF (100 ng/ml), IL-3 (20 ng/ml), IL-6 (20 ng/ml) and penicillin/streptomycin. Cells were harvested for total RNA extraction at the proerythroblast stage of differentiation.
Control stem cell differentiation study 50 (mock shRNA; ASC; proerythroblast)
Proerythroblast differentiated from control shRNA transduced hematopoietic stem/progenitor cells (CD34+). CD34+ hematopoietic stem/progenitor cells (HSC) were transduced with lentivirus expressing control shRNA with following differentiation to the erythroid lineage. HSCs were obtained from magnetically sorted G-CSF mobilized peripheral blood mononuclear cells of healthy donors. Cells were expanded in StemSpan SFEM medium supplied with Flt-3 ligand (100 ng/ml), SCF (100 ng/ml), IL-3 (20 ng/ml), IL-6 (20 ng/ml) and penicillin/streptomycin. Cells were harvested for total RNA extraction at the proerythroblast stage of differentiation.

lung adenocarcinoma study 3 (positive) / normal lung tissue

Relative Expression (log2-ratio):-3.124217
Number of Samples:7 / 3
Experimental lung adenocarcinoma study 3 (positive)
Primary lung adenocarcinoma samples, with bone marrow positive for early disseminated tumor cells (DTCs). The presence of DTCs can predict the subsequent occurrence of overt metastasis and survival in lung cancer.
Control normal lung tissue
Normal lung tissue.

lung adenocarcinoma study 3 (negative) / normal lung tissue

Relative Expression (log2-ratio):-2.9277515
Number of Samples:9 / 3
Experimental lung adenocarcinoma study 3 (negative)
Primary lung adenocarcinoma samples, with bone marrow negative for early disseminated tumor cells (DTCs). The presence of DTCs can predict the subsequent occurrence of overt metastasis and survival in lung cancer.
Control normal lung tissue
Normal lung tissue.

lung adenocarcinoma study 6 (K-RAS mut) / adjacent lung tissue

Relative Expression (log2-ratio):-2.6316051
Number of Samples:6 / 20
Experimental lung adenocarcinoma study 6 (K-RAS mut)
Primary tumor sample from patients with stage II adenocarcinoma carrying a K-RAS mutation.
Control adjacent lung tissue
Adjacent and histologically normal, non-tumorous lung tissue samples from patients with lung adenocarcinoma.

lung adenocarcinoma study 5 (K-RAS mut) / adjacent lung tissue

Relative Expression (log2-ratio):-2.220295
Number of Samples:14 / 20
Experimental lung adenocarcinoma study 5 (K-RAS mut)
Primary tumor sample from patients with stage I adenocarcinoma carrying a K-RAS mutation.
Control adjacent lung tissue
Adjacent and histologically normal, non-tumorous lung tissue samples from patients with lung adenocarcinoma.

lung adenocarcinoma study 3 / adjacent lung tissue

Relative Expression (log2-ratio):-2.215435
Number of Samples:93 / 98
Experimental lung adenocarcinoma study 3
Primary adenocarcinoma samples from the lung of patients with different stages and smoking status.
Control adjacent lung tissue
Adjacent, histologically normal and non-neoplastic tissue sample from the lung of patients with primary adenocarcinoma of the lung. Patients had different stages and smoking status.

non-small cell lung cancer study 8 (large cell carcinoma) / adjacent lung tissue

Relative Expression (log2-ratio):-2.1592817
Number of Samples:18 / 65
Experimental non-small cell lung cancer study 8 (large cell carcinoma)
Primary tumor tissue sample obtained from the lung of patients large cell carcinoma.
Control adjacent lung tissue
Histological normal lung tissue samples from patients with lung cancer.

Merkel cell carcinoma study 3 (primary) / normal skin tissue

Relative Expression (log2-ratio):-2.1503944
Number of Samples:38 / 64
Experimental Merkel cell carcinoma study 3 (primary)
Primary tumor tissue from the skin of patients with Merkel cell carcinoma.
Control normal skin tissue
Normal skin samples from healthy donors.

idiopathic pulmonary fibrosis study 4 (early) / normal lung tissue

Relative Expression (log2-ratio):2.1098938
Number of Samples:8 / 5
Experimental idiopathic pulmonary fibrosis study 4 (early)
Lung tissue samples from patients with early idiopathic pulmonary fibrosis obtained after surgical biopsy.
Control normal lung tissue
Normal lung tissue samples from healthy donors obtained after routine lung volume reduction at the time of lung transplantation.

lung squamous cell carcinoma study 1 / normal lung tissue

Relative Expression (log2-ratio):-2.1003246
Number of Samples:31 / 44
Experimental lung squamous cell carcinoma study 1
Primary lung squamous cell carcinoma samples of a patient with non-small cell lung cancer.
Control normal lung tissue
Histologically normal lung tissue.