TOP TEN perturbations for NM_000146 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000146
Selected probe(set): 212788_x_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000146 (212788_x_at) across 5339 perturbations tested by GENEVESTIGATOR:

glioma study 16 (BS-149) / normal astrocyte sample

Relative Expression (log2-ratio):2.2623692
Number of Samples:2 / 3
Experimental glioma study 16 (BS-149)
Human glioma cell line BS149 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37?C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

glioma study 16 (LN-319) / normal astrocyte sample

Relative Expression (log2-ratio):2.205
Number of Samples:2 / 3
Experimental glioma study 16 (LN-319)
Human glioma cell line LN319 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37?C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

glioma study 16 (LN-18) / normal astrocyte sample

Relative Expression (log2-ratio):2.1714764
Number of Samples:2 / 3
Experimental glioma study 16 (LN-18)
Human glioma cell line LN018 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

mycosis fungoides study 1 (tumor phase) / normal skin tissue

Relative Expression (log2-ratio):1.8825722
Number of Samples:4 / 8
Experimental mycosis fungoides study 1 (tumor phase)
Lesional skin biopsies from patients with mycosis fungoides in the plaque phase.
Control normal skin tissue
Skin biopsies from healthy individuals.

glioma study 16 (LN-215) / normal astrocyte sample

Relative Expression (log2-ratio):1.8731937
Number of Samples:2 / 3
Experimental glioma study 16 (LN-215)
Human glioma cell line LN215 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37?C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

glioma study 16 (LN-229) / normal astrocyte sample

Relative Expression (log2-ratio):1.8714542
Number of Samples:2 / 3
Experimental glioma study 16 (LN-229)
Human glioma cell line LN229 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37?C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

esophageal adenocarcinoma study 1 / normal esophageal epithelium sample

Relative Expression (log2-ratio):1.5441513
Number of Samples:20 / 18
Experimental esophageal adenocarcinoma study 1
Esophageal adenocarcinoma (EAC) samples of affected epithelium recovered by laser capture microdissection technique.
Control normal esophageal epithelium sample
Histologically normal esophageal squamous cell epithelium biopsy samples from patients that were investigated for esophageal pain, but diagnosed as healthy.

CREB1 depletion study 2 (HSY) / control transduced HSY cell sample

Relative Expression (log2-ratio):-1.5016747
Number of Samples:3 / 3
Experimental CREB1 depletion study 2 (HSY)
HSY cells with shRNA mediated knock down of CREB1. Cells were infected on two consecutive dates with the lentiviruses in fresh complete medium (DMEM, 10% FBS) plus 8ug/ml polybrene for 6 to 8 hours and replaced with fresh medium. Cells were harvested at 72 hours after the 1st infection.
Control control transduced HSY cell sample
HSY cells expressing a control shRNA targeting luciferase gene (shLuc). Cells were infected on two consecutive dates with the lentiviruses in fresh complete medium (DMEM, 10% FBS) plus 8ug/ml polybrene for 6 to 8 hours and replaced with fresh medium. Cells were harvested at 72 hours after the 1st infection.

exercise study 20 (exercised; day 4; 2 bouts) / normal vastus lateralis muscle tissue (exercised; baseline)

Relative Expression (log2-ratio):1.4670639
Number of Samples:7 / 8
Experimental exercise study 20 (exercised; day 4; 2 bouts)
Vastus lateralis muscle tissue biopsy taken 24 hours after two sessions of 5 x 30 maximum isokinetic knee extensions (180?/s) exercises separated by 48 hours. Samples were taken from the dominant leg of healthy non-smoking recreationally active men that had never taken part in lower body resistance exercise training (age 22 ? 2 y; body mass index 23 ? 2 kg/m2).
Control normal vastus lateralis muscle tissue (exercised; baseline)
Vastus lateralis muscle biopsy from the dominant leg of healthy non-smoking recreationally active men that had never taken part in lower body resistance exercise training (age 22 ? 2 y; body mass index 23 ? 2 kg/m2). Biopsy was taken prior to the exercise study (baseline).

saccular intracranial aneurysm study 1 (ruptured) / saccular intracranial aneurysm study 1 (unruptured)

Relative Expression (log2-ratio):1.4545326
Number of Samples:11 / 8
Experimental saccular intracranial aneurysm study 1 (ruptured)
Human aneurysm pouches obtained from aneurysmal subarachnoid hemorrhage (aSAH) from ruptured saccular intracranial aneurysm (sIA).
Control saccular intracranial aneurysm study 1 (unruptured)
Human aneurysm pouches obtained from aneurysmal subarachnoid hemorrhage (aSAH) from unruptured saccular intracranial aneurysm (sIA).