TOP TEN perturbations for NM_000151 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000151
Selected probe(set): 206952_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000151 (206952_at) across 5339 perturbations tested by GENEVESTIGATOR:

PGC-1 overexpr. study 1 (2x9) / control transfected HEPG2 sample

Relative Expression (log2-ratio):6.5779257
Number of Samples:3 / 3
Experimental PGC-1 overexpr. study 1 (2x9)
HEP-G2 cells infected with adenoviruses carrying a mutant form of PPARG Coactivator 1 Alpha (PGC-1) where L2 and L3 motifs of PGC-1 were replaced with sequences corresponding to the L3-09 peptide (2x9). Cells were analyzed 24 hours after infection.
Control control transfected HEPG2 sample
HEp-G2 cells infected with adenoviruses carrying B-galactosidase as a control. Cells were analyzed 24 hours after infection.

hepatocyte (ESC) / HepaRG

Relative Expression (log2-ratio):-6.38799
Number of Samples:8 / 12
Experimental hepatocyte (ESC)
Hepatocyte-like cells differentiated from embryonic stem cells (ESC)
Control HepaRG
Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code:

theophylline study 5 (10000uM) / vehicle (medium) treated hepatocyte sample

Relative Expression (log2-ratio):5.9131846
Number of Samples:2 / 2
Experimental theophylline study 5 (10000uM)
Hepatocytes treated with compound: theophylline (10000uM; CHEMBL190) for 24 hours. ATC code:
Control vehicle (medium) treated hepatocyte sample
Hepatocytes treated with vehicle (medium) for 24 hours.

PGC-1 overexpr. study 1 (WT) / control transfected HEPG2 sample

Relative Expression (log2-ratio):5.5254774
Number of Samples:3 / 3
Experimental PGC-1 overexpr. study 1 (WT)
HEP-G2 cells infected with adenoviruses carrying a wild-type form of PPARG Coactivator 1 Alpha (PGC-1). Cells were analyzed 24 hours after infection.
Control control transfected HEPG2 sample
HEp-G2 cells infected with adenoviruses carrying B-galactosidase as a control. Cells were analyzed 24 hours after infection.

cyclophosphamide study 6 (700 uM; HepaRG) / vehicle (DMSO) treated HepaRG cell sample

Relative Expression (log2-ratio):-5.3184175
Number of Samples:3 / 12
Experimental cyclophosphamide study 6 (700 uM; HepaRG)
HepaRG cells exposed to 700 uM cyclophosphamide (dissolved in 0.5% v/v DMSO) for 72 hours. Cells were cultivated in DMSO-containing medium between days 13 - 19 to allow them to differentiate into hepatocyte-like cells and become fully functional. Chemical was added at day 19 of cultivation. Cells were treated with the IC10 determined by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test (number of replicates, n = 3). ATC code:
Control vehicle (DMSO) treated HepaRG cell sample
HepaRG cells treated with vehicle (DMSO 0.5% v/v) for 72 hours. Firstly, cells were cultivated in DMSO-containing medium between days 13 - 19 to allow them to differentiate into hepatocyte-like cells and become fully functional. Then the vehicle was added.

collecting duct carcinoma study 1 / normal kidney tissue

Relative Expression (log2-ratio):-5.0042834
Number of Samples:2 / 3
Experimental collecting duct carcinoma study 1
Tumor tissue samples from the kidney of patients with collecting duct carcinoma (CDC).
Control normal kidney tissue
Normal adult kidney tissue samples.

clear cell renal cell carcinoma study 4 (stage 3) / normal kidney tissue

Relative Expression (log2-ratio):-4.9915504
Number of Samples:14 / 69
Experimental clear cell renal cell carcinoma study 4 (stage 3)
Primary tumor tissue from patients with stage 3 clear cell renal cell carcinoma (ccRCC).
Control normal kidney tissue
Normal kidney tissue samples obtained from healthy individuals.

oxyphilic adenoma study 1 / normal kidney tissue

Relative Expression (log2-ratio):-4.9137573
Number of Samples:4 / 3
Experimental oxyphilic adenoma study 1
Tumor tissue samples from the kidney of patients with oxyphilic adenoma (renal oncocytoma).
Control normal kidney tissue
Normal adult kidney tissue samples.

renal cell carcinoma study 5 (papillary type) / normal kidney tissue

Relative Expression (log2-ratio):-4.906405
Number of Samples:19 / 3
Experimental renal cell carcinoma study 5 (papillary type)
Tumor tissue samples from the kidney of patients with papillary renal cell carcinoma (pRCC).
Control normal kidney tissue
Normal adult kidney tissue samples.

renal cell carcinoma study 6 (chromophobe type) / normal kidney tissue

Relative Expression (log2-ratio):-4.8941765
Number of Samples:4 / 3
Experimental renal cell carcinoma study 6 (chromophobe type)
Tumor tissue samples from the kidney of patients with chromophobe renal cell carcinoma (cRCC).
Control normal kidney tissue
Normal adult kidney tissue samples.