TOP TEN perturbations for NM_000192 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000192
Selected probe(set): 240715_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000192 (240715_at) across 5392 perturbations tested by GENEVESTIGATOR:

TC-71 / TC-32

Relative Expression (log2-ratio):-6.019309
Number of Samples:6 / 6
Experimental TC-71
Human primary cancer cell line derived from the humerus of a patient with Ewing sarcoma. Synonyms:TC71; GM11654 Cellosaurus code:
Control TC-32
Human primary cancer cell line derived from the unspecified origin of a patient with Ewing?s sarcoma. Synonyms:TC32 Cellosaurus code:

breast cancer study 42 (metastase; lymph node) / breast cancer study 42 (metastase; liver)

Relative Expression (log2-ratio):3.719987
Number of Samples:7 / 3
Experimental breast cancer study 42 (metastase; lymph node)
Metastatic tumor tissue obtained from the lymph node of patients with primary breast adenocarcinoma.
Control breast cancer study 42 (metastase; liver)
Metastatic tumor tissue obtained from the liver of patients with primary breast adenocarcinoma.

systemic lupus erythematosus study 13 (untreated) / normal PBMC sample

Relative Expression (log2-ratio):-3.6733513
Number of Samples:4 / 5
Experimental systemic lupus erythematosus study 13 (untreated)
Peripheral blood mononuclear cells (PBMCs) obtained from systemic lupus erythematosus (SLE) patients. Freshly isolated PBMCs were cultured in RPMI/10% FBS for 6 hours. Lupus patients fulfilled American College of Rheumatology classification criteria for disease, and disease activity was quantified by SLEDAI. Patients were excluded if they showed symptoms of recent or active infection or were pregnant. None of the patients was taking Pioglitazone or other PPAR-? agonists.
Control normal PBMC sample
Peripheral blood mononuclear cells (PBMCs) obtained from healthy subjects. Freshly isolated PBMCs were cultured in RPMI/10% FBS for 6 hours.

colorectal cancer study 43 (metastase; lung) / colorectal cancer study 43 (metastase; liver)

Relative Expression (log2-ratio):3.3731184
Number of Samples:5 / 25
Experimental colorectal cancer study 43 (metastase; lung)
Metastatic tumor tissue obtained from the lung of patients with primary colon adenocarcinoma.
Control colorectal cancer study 43 (metastase; liver)
Metastatic tumor tissue obtained from the liver of patients with primary colon adenocarcinoma.

colorectal cancer study 43 (metastase; brain) / colorectal cancer study 43 (metastase; lung)

Relative Expression (log2-ratio):-3.0999403
Number of Samples:2 / 5
Experimental colorectal cancer study 43 (metastase; brain)
Metastatic tumor tissue obtained from the brain of patients with primary colorectal adenocarcinoma.
Control colorectal cancer study 43 (metastase; lung)
Metastatic tumor tissue obtained from the lung of patients with primary colon adenocarcinoma.

rheumatoid arthritis study 15 (non-inflammatory) / rheumatoid arthritis study 13 (non-inflammatory)

Relative Expression (log2-ratio):-3.0618172
Number of Samples:3 / 2
Experimental rheumatoid arthritis study 15 (non-inflammatory)
Synovial tissue samples from patients with rheumatoid arthritis (RA) taken from a non-inflammatory joint of the hip.
Control rheumatoid arthritis study 13 (non-inflammatory)
Synovial tissue samples from patients with rheumatoid arthritis (RA) taken from a non-inflammatory joint.

mycosis fungoides study 1 (tumor phase) / mycosis fungoides study 1 (patch phase)

Relative Expression (log2-ratio):-2.9019442
Number of Samples:4 / 2
Experimental mycosis fungoides study 1 (tumor phase)
Lesional skin biopsies from patients with mycosis fungoides in the plaque phase.
Control mycosis fungoides study 1 (patch phase)
Lesional skin biopsies from patients with mycosis fungoides in the patch phase.

prostate cancer study 8 (p. canc) / prostate cancer study 8 (psfmc)

Relative Expression (log2-ratio):-2.57401
Number of Samples:3 / 5
Experimental prostate cancer study 8 (p. canc)
CD26+ FACS sorted prostate neoplasm cell (p. canc) samples from patients with primary prostate cancer collected after radical prostatectomy.
Control prostate cancer study 8 (psfmc)
CD49a+ FACS sorted prostate stromal fibromuscular cell (psfmc) samples from patients with primary prostate cancer collected after radical prostatectomy.

cutaneous sarcoidosis study 1 (lesional) / normal skin tissue

Relative Expression (log2-ratio):-2.4248295
Number of Samples:13 / 5
Experimental cutaneous sarcoidosis study 1 (lesional)
Lesional skin biopsies from patients with acute cutaneous sarcoidosis.
Control normal skin tissue
Skin biopsy samples from healthy control subjects.

mycosis fungoides study 1 (patch phase) / normal skin tissue

Relative Expression (log2-ratio):2.3904305
Number of Samples:2 / 8
Experimental mycosis fungoides study 1 (patch phase)
Lesional skin biopsies from patients with mycosis fungoides in the patch phase.
Control normal skin tissue
Skin biopsies from healthy individuals.