TOP TEN perturbations for NM_000197 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000197
Selected probe(set): 206985_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000197 (206985_at) across 5392 perturbations tested by GENEVESTIGATOR:

cisplatin study 7 (48h) / vehicle (PBS) treated HepG2 cell sample

Relative Expression (log2-ratio):3.1301222
Number of Samples:3 / 9
Experimental cisplatin study 7 (48h)
HepG2 cells exposed to 20?M cisplatin in PBS solvent for 48 hours. ATC code:
Control vehicle (PBS) treated HepG2 cell sample
HepG2 cells exposed to 0.5% PBS solvent for 48 hours.

ENU study 1 (48h) / vehicle (DMSO) treated HepG2 cell sample

Relative Expression (log2-ratio):2.8158445
Number of Samples:3 / 19
Experimental ENU study 1 (48h)
HepG2 cells exposed to 1mM 1-ethyl-1-nitrosourea (ENU) in DMSO solvent for 48 hours. ATC code:---
Control vehicle (DMSO) treated HepG2 cell sample
HepG2 cells exposed to DMSO solvent for 48 hours.

HIV-associated neurocognitive disorder study 4 (ischemia) / normal genu sample

Relative Expression (log2-ratio):2.5727768
Number of Samples:2 / 8
Experimental HIV-associated neurocognitive disorder study 4 (ischemia)
Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with ischemia. The patients did not receive any antiretroviral therapy (ART).
Control normal genu sample
Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from healthy subjects.

glioma study 16 (oligodendroglioma) / normal brain tissue

Relative Expression (log2-ratio):-2.2196312
Number of Samples:7 / 2
Experimental glioma study 16 (oligodendroglioma)
Primary oligodendroglioma tissues obtained from the operating room. Tumors were diagnosed and graded according to the current WHO classification (grade OGII-III).
Control normal brain tissue
Normal brain tissue sample from healthy donors.

male infertility study 1 (mJS2) / normal testicular lobules tissue (mJS10)

Relative Expression (log2-ratio):2.1935415
Number of Samples:7 / 8
Experimental male infertility study 1 (mJS2)
Human testicular lobules biopsy samples isolated from adult infertile patients whose seminiferous tubules contained almost exclusively Sertoli cells. Tissue samples were classified based on modified Johnsen score (mJS) as mJS2.
Control normal testicular lobules tissue (mJS10)
Biopsies of human testicular lobules isolated from fertile vasectomized adult men with normal spermatogenesis. Histological analysis classified samples as mJS10 (modified Johnsen score 10).

retina pigment epithelium study 2 (fetal) / retina pigment epithelium study 1 (fetal)

Relative Expression (log2-ratio):2.1018782
Number of Samples:12 / 6
Experimental retina pigment epithelium study 2 (fetal)
Human cultured fetal retina pigment epithelium samples obtained at gestation age between week 16-18.
Control retina pigment epithelium study 1 (fetal)
Human native fetal retina pigment epithelium samples obtained at gestation age between week 16-18.

glioma study 16 (astrocytoma) / normal brain tissue

Relative Expression (log2-ratio):-2.0781279
Number of Samples:8 / 2
Experimental glioma study 16 (astrocytoma)
Primary astrocytoma tissues obtained from the operating room. Tumors were diagnosed and graded according to the current WHO classification (grade III-IV).
Control normal brain tissue
Normal brain tissue sample from healthy donors.

male infertility study 1 (mJS3) / normal testicular lobules tissue (mJS10)

Relative Expression (log2-ratio):1.8716459
Number of Samples:3 / 8
Experimental male infertility study 1 (mJS3)
Human testicular lobules biopsy samples isolated from adult infertile patients whose seminiferous tubules contained Sertoli cells but rarely spermatogonia. Tissue samples were classified based on modified Johnsen score (mJS) as mJS3.
Control normal testicular lobules tissue (mJS10)
Biopsies of human testicular lobules isolated from fertile vasectomized adult men with normal spermatogenesis. Histological analysis classified samples as mJS10 (modified Johnsen score 10).

decitabine; TSA study 4 / mock treated bronchial epithelial cell sample

Relative Expression (log2-ratio):1.6723738
Number of Samples:3 / 3
Experimental decitabine; TSA study 4
Normal human bronchial epithelial cells treated with 5uM 5-aza-2'-deoxycitidine (INN: decitabine) for 72 hours and trichostatin A (TSA) for 24 hours (stock solutions of 5-aza-2'-deoxycitidine and TSA were dissolved in 50% aceticacid). ATC code:
Control mock treated bronchial epithelial cell sample
Normal human bronchial epithelial cells mock treated.

HCC study 20 (CDX; Hep-G2; ectopic) / HCC study 20 (PDX; ectopic)

Relative Expression (log2-ratio):-1.6070318
Number of Samples:3 / 11
Experimental HCC study 20 (CDX; Hep-G2; ectopic)
Tumor tissue biopsy samples from Hep-G2 cell line-derived xenograft (CDX) ectopically generated in SCID mice by injecting hepatocellular carcinoma cells subcutaneously. In order to establish ectopic models, cells were injected subcutaneously into the flank regions. The mice were euthanized after two weeks.
Control HCC study 20 (PDX; ectopic)
Tumor tissue biopsy samples from patient-derived xenograft (PDX) sample ectopically generated in SCID mice by injecting hepatocellular carcinoma cells subcutaneously. Donor tumor tissue was obtained intraoperatively during liver resection from three patients. All three patients had hepatocellular carcinoma confirmed by histology. In order to establish ectopic models, cells were injected subcutaneously into the flank regions. The mice were euthanized after two weeks.