TOP TEN perturbations for NM_000198 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000198
Selected probe(set): 206294_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000198 (206294_at) across 5339 perturbations tested by GENEVESTIGATOR:

adrenal gland cancer study 4 / normal adrenal cortex tissue

Relative Expression (log2-ratio):-4.8739214
Number of Samples:43 / 4
Experimental adrenal gland cancer study 4
Primary tumor tissue samples of the adrenal cortex from patients with adrenocortical carcinoma (ACC).
Control normal adrenal cortex tissue
Histological normal adrenal gland cortical tissue samples derived after autopsy.

colorectal cancer study 4 (recurring) / adjacent colon tissue (recurring)

Relative Expression (log2-ratio):-4.750345
Number of Samples:24 / 3
Experimental colorectal cancer study 4 (recurring)
LCM-tumor tissue samples of patients who received resection after diagnosis of primary colorectal cancer. Patients developed metastatic recurrence during follow-up after surgery.
Control adjacent colon tissue (recurring)
Histologically normal colon tissue samples from patients with primary colorectal cancer collected after resection. Tissue was further extracted using laser-capture microdissection (LCM). With metastatic recurrence after resection during follow-up.

colorectal cancer study 4 (metastatic progression) / adjacent colon tissue (metastatic progression)

Relative Expression (log2-ratio):-4.242998
Number of Samples:23 / 4
Experimental colorectal cancer study 4 (metastatic progression)
LCM-tumor tissue samples of patients who received resection after diagnosis of primary colorectal cancer with metastatic progression.
Control adjacent colon tissue (metastatic progression)
Histologically normal colon tissue samples from patients with primary colorectal cancer and metastatic progression collected after resection. Tissue was further extracted using laser-capture microdissection (LCM).

colorectal cancer study 33 (carcinoma; colonic mucosa) / normal colon mucosa sample

Relative Expression (log2-ratio):-4.1845894
Number of Samples:5 / 5
Experimental colorectal cancer study 33 (carcinoma; colonic mucosa)
Colonic mucosa samples obtained by laser capture microdissection (LCM) from patients with colorectal carcinoma.
Control normal colon mucosa sample
Histopathological normal colon mucosa sample obtained by laser capture microdissection (LCM) from the distant normal colon of patients with colorectal cancer.

ulcerative colitis study 9 (prior therapy) / normal colon tissue

Relative Expression (log2-ratio):-4.1489067
Number of Samples:8 / 11
Experimental ulcerative colitis study 9 (prior therapy)
Colon biopsies derived from pediatric patients diagnosed with ulcerative colitis at time of enrollment. Patients were not receiving medications for the treatment of inflammatory bowel disease at the time the biopsy was taken.
Control normal colon tissue
Colon biopsies derived from pediatric healthy controls.

colorectal adenoma study 7 (colonic mucosa) / normal colon mucosa sample

Relative Expression (log2-ratio):-4.043992
Number of Samples:5 / 5
Experimental colorectal adenoma study 7 (colonic mucosa)
Colonic mucosa samples obtained by laser capture microdissection (LCM) from patients with colorectal adenoma.
Control normal colon mucosa sample
Histopathological normal colon mucosa sample obtained by laser capture microdissection (LCM) from the distant normal colon of patients with colorectal cancer.

male infertility study 1 (mJS3) / normal testicular lobules tissue (mJS10)

Relative Expression (log2-ratio):3.9930525
Number of Samples:3 / 8
Experimental male infertility study 1 (mJS3)
Human testicular lobules biopsy samples isolated from adult infertile patients whose seminiferous tubules contained Sertoli cells but rarely spermatogonia. Tissue samples were classified based on modified Johnsen score (mJS) as mJS3.
Control normal testicular lobules tissue (mJS10)
Biopsies of human testicular lobules isolated from fertile vasectomized adult men with normal spermatogenesis. Histological analysis classified samples as mJS10 (modified Johnsen score 10).

male infertility study 1 (mJS2) / normal testicular lobules tissue (mJS10)

Relative Expression (log2-ratio):3.9334602
Number of Samples:7 / 8
Experimental male infertility study 1 (mJS2)
Human testicular lobules biopsy samples isolated from adult infertile patients whose seminiferous tubules contained almost exclusively Sertoli cells. Tissue samples were classified based on modified Johnsen score (mJS) as mJS2.
Control normal testicular lobules tissue (mJS10)
Biopsies of human testicular lobules isolated from fertile vasectomized adult men with normal spermatogenesis. Histological analysis classified samples as mJS10 (modified Johnsen score 10).

colorectal adenoma study 1 (small) / adjacent colon mucosa tissue

Relative Expression (log2-ratio):-3.6955786
Number of Samples:3 / 4
Experimental colorectal adenoma study 1 (small)
Ascending colon biopsies of colorectal adenomas (size: 1cm - 2cm).
Control adjacent colon mucosa tissue
Biopsies of ascending colon mucosa from adjacent tumor tissue.

adrenal gland cancer study 2 / adrenal gland cancer study 1

Relative Expression (log2-ratio):-3.619009
Number of Samples:31 / 22
Experimental adrenal gland cancer study 2
Primary tumor tissue samples of the adrenal cortex from patients with adrenocortical carcinoma.
Control adrenal gland cancer study 1
Primary tumor tissue samples of the adrenal cortex from patients with adrenocortical adenoma.