TOP TEN perturbations for NM_000199 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000199
Selected probe(set): 35626_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000199 (35626_at) across 5339 perturbations tested by GENEVESTIGATOR:

male infertility study 1 (juvenile; Ad-) / normal testicular lobules tissue (mJS10)

Relative Expression (log2-ratio):2.5367842
Number of Samples:2 / 8
Experimental male infertility study 1 (juvenile; Ad-)
Human testicular lobules biopsy samples isolated from prepubescent patients with undescended testes. Testes of these children contained very low level of A-dark (Ad-) spermatogonial cells.
Control normal testicular lobules tissue (mJS10)
Biopsies of human testicular lobules isolated from fertile vasectomized adult men with normal spermatogenesis. Histological analysis classified samples as mJS10 (modified Johnsen score 10).

IgG; C3bi stimulation study 1 (late) / normal polymorphnuclear leukocyte sample

Relative Expression (log2-ratio):2.5287533
Number of Samples:10 / 11
Experimental IgG; C3bi stimulation study 1 (late)
Polymorphonuclear leukocytes (PMNs) from healthy donors, incubated with IgG- and C3bi-coated latex beads at 37?C in a CO2 incubator for 6h. ATC code:---
Control normal polymorphnuclear leukocyte sample
Polymorphonuclear leukocytes (PMNs) from healthy donors, incubated without IgG- and C3bi-coated latex beads at 37?C in a CO2 incubator for 6h.

male infertility study 1 (juvenile; Ad+) / normal testicular lobules tissue (mJS10)

Relative Expression (log2-ratio):2.4031
Number of Samples:5 / 8
Experimental male infertility study 1 (juvenile; Ad+)
Human testicular lobules biopsy samples isolated from prepubescent patients with undescended testes. Testes of these children contained typical level of A-dark (Ad+) spermatogonial cells.
Control normal testicular lobules tissue (mJS10)
Biopsies of human testicular lobules isolated from fertile vasectomized adult men with normal spermatogenesis. Histological analysis classified samples as mJS10 (modified Johnsen score 10).

IgG; C3bi stimulation study 1 (early) / normal polymorphnuclear leukocyte sample

Relative Expression (log2-ratio):2.3804893
Number of Samples:11 / 10
Experimental IgG; C3bi stimulation study 1 (early)
Polymorphonuclear leukocytes (PMNs) from healthy donors, incubated with IgG- and C3bi-coated latex beads at 37?C in a CO2 incubator for 3h. ATC code:---
Control normal polymorphnuclear leukocyte sample
Polymorphonuclear leukocytes (PMNs) from healthy donors, incubated without IgG- and C3bi-coated latex beads at 37?C in a CO2 incubator for 3h.

IgG; C3bi stimulation study 2 (late) / untreated polymorphnuclear leukocyte sample (Job's syndrome)

Relative Expression (log2-ratio):2.2841787
Number of Samples:7 / 6
Experimental IgG; C3bi stimulation study 2 (late)
Polymorphonuclear leukocytes (PMNs) from Job's syndrome patients, incubated with IgG- and C3bi-coated latex beads at 37?C in a CO2 incubator for 6h. ATC code:---
Control untreated polymorphnuclear leukocyte sample (Job's syndrome)
Polymorphonuclear leukocytes (PMNs) from Job's syndrome patients, incubated without IgG- and C3bi-coated latex beads at 37?C in a CO2 incubator for 6h.

IgG; C3bi stimulation study 2 (early) / untreated polymorphnuclear leukocyte sample (Job's syndrome)

Relative Expression (log2-ratio):2.2213593
Number of Samples:7 / 7
Experimental IgG; C3bi stimulation study 2 (early)
Polymorphonuclear leukocytes (PMNs) from Job's syndrome patients, incubated with IgG- and C3bi-coated latex beads at 37?C in a CO2 incubator for 3h. ATC code:---
Control untreated polymorphnuclear leukocyte sample (Job's syndrome)
Polymorphonuclear leukocytes (PMNs) from Job's syndrome patients, incubated without IgG- and C3bi-coated latex beads at 37?C in a CO2 incubator for 3h.

LPS study 4 / mock treated MONO-MAC-6 cell sample

Relative Expression (log2-ratio):2.1560974
Number of Samples:2 / 2
Experimental LPS study 4
MONO-MAC-6 (MM6) cells were treated with 10 ng/ml lipopolysaccharide (LPS). ATC code:---
Control mock treated MONO-MAC-6 cell sample
MONO-MAC-6 (MM6) cells mock treated.

colorectal adenoma study 2 / normal colon tissue

Relative Expression (log2-ratio):-2.076726
Number of Samples:5 / 6
Experimental colorectal adenoma study 2
Laser microdissected human adenoma sample.
Control normal colon tissue
Laser microdissected human colonic epithelial cells sample.

OPM-1 / MM1.S

Relative Expression (log2-ratio):-2.0207615
Number of Samples:4 / 4
Experimental OPM-1
Human primary cancer cell line derived from the peripheral blood of a patient with multiple myeloma. Dexamethasone-resistant. Synonyms:OPM1 Cellosaurus code:
Control MM1.S
Human primary cancer cell line derived from the peripheral blood of a patient with multiple myeloma. Dexamethasone-sensitive. Parental cell line:: MM.1 Synonyms:MM.1S; MM1-S; MM-1S; MM1S Cellosaurus code:

CML study 1 / B-CLL study 5

Relative Expression (log2-ratio):-1.9971724
Number of Samples:75 / 441
Experimental CML study 1
Bone marrow samples of patients with chronic myeloid leukemia (CML).
Control B-CLL study 5
Bone marrow samples of patients with B-cell chronic lymphocytic leukemia (B-CLL).