TOP TEN perturbations for NM_000200 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000200
Selected probe(set): 206786_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000200 (206786_at) across 5339 perturbations tested by GENEVESTIGATOR:

baculovirus study 2 / uninfected differentiated neuronal cell sample

Relative Expression (log2-ratio):2.2549324
Number of Samples:3 / 3
Experimental baculovirus study 2
Human clonal cord blood stem cells trans-differentiated into human neuronal cells that were initially derived from the human CD34+ and CD133+ cord blood stem cell population. Cells were infected 48h with Baculovirus (multiplicity of infection 100) expressing GFP.
Control uninfected differentiated neuronal cell sample
Human clonal cord blood stem cells transdifferentiated into human neuronal cells that were initially derived from the human CD34+ and CD133+ cord blood stem cell population; uninfected cells.

Merkel cell carcinoma study 3 (metastatic) / normal skin tissue

Relative Expression (log2-ratio):2.1898723
Number of Samples:22 / 64
Experimental Merkel cell carcinoma study 3 (metastatic)
Metastatic tumor tissue from different metastatic sites (skin, lymph node, parotid gland) of patients with Merkel cell carcinoma of the skin.
Control normal skin tissue
Normal skin samples from healthy donors.

DLBCL study 4 (unclassified DLBCL; baseline; RCHOP; dead) / DLBCL study 4 (unclassified DLBCL; baseline; RCHOP; alive)

Relative Expression (log2-ratio):2.079793
Number of Samples:5 / 28
Experimental DLBCL study 4 (unclassified DLBCL; baseline; RCHOP; dead)
Tumor lymph node biopsy samples of patients with unclassified diffuse large B-cell lymphoma (DLBCL) collected before any treatment. Later patients received chemotherapy composed of cyclophosphamide, doxorubicin, vincristine, prednisone with monoclonal antibody rituximab (RCHOP) and during follow up period they died from unknown reasons.
Control DLBCL study 4 (unclassified DLBCL; baseline; RCHOP; alive)
Tumor lymph node biopsy samples of patients with unclassified diffuse large B-cell lymphoma (DLBCL) collected before any treatment. Later patients received chemotherapy composed of cyclophosphamide, doxorubicin, vincristine, prednisone with monoclonal antibody rituximab (RCHOP) and during follow up period they were alive.

DLBCL study 1 (germinal center B-cell like; centroblast-like) / DLBCL study 1 (activated B-cell like; centroblast-like)

Relative Expression (log2-ratio):-1.894042
Number of Samples:14 / 3
Experimental DLBCL study 1 (germinal center B-cell like; centroblast-like)
Centroblast B-cells sorted from primary tumor samples from patients with malignant diffuse large B-cell lymphoma (germinal center B-cell like type). To isolate different B-cell subsets, tonsil tissues from DLBCL patients were sorted by fluorescence-activated cell sorting. Samples were also classified based on subset-specific B-cell-associated gene signature (BAGS).
Control DLBCL study 1 (activated B-cell like; centroblast-like)
Centroblast B-cells sorted from primary tumor samples from patients with malignant diffuse large B-cell lymphoma (activated B-cell like type). To isolate different B-cell subsets, tonsil tissues from DLBCL patients were sorted by fluorescence-activated cell sorting. Samples were also classified based on subset-specific B-cell-associated gene signature (BAGS).

asthma study 22 (eosinophilic AIP) / asthma study 22 (neutrophilic AIP)

Relative Expression (log2-ratio):1.5343533
Number of Samples:15 / 17
Experimental asthma study 22 (eosinophilic AIP)
Sputum samples from asthmatic patients with eosinophilic airway inflammatory phenotype (AIP).
Control asthma study 22 (neutrophilic AIP)
Sputum samples from asthmatic patients with neutrophilic airway inflammatory phenotype (AIP).

human herpes virus-8 study 1 / mock infected pulmonary microvascular endothelial cell sample

Relative Expression (log2-ratio):1.492775
Number of Samples:3 / 3
Experimental human herpes virus-8 study 1
Primary human pulmonary microvascular endothelial cells (HMVEC-L) were infected with human herpesvirus-8 (HHV-8) for 72 hours.
Control mock infected pulmonary microvascular endothelial cell sample
Primary human pulmonary microvascular endothelial cells (HMVEC-L) were mock-infected for 72 hours in incubation media.

RAF1 depletion study 2 / control vector transfected SW-620 cell sample

Relative Expression (log2-ratio):1.4599643
Number of Samples:6 / 6
Experimental RAF1 depletion study 2
RNAi-mediated gene knockdown of RAF1 in colorectal cancer cell line SW-620.
Control control vector transfected SW-620 cell sample
SW-620 colorectal cell line sample transduced with empty vector pLKO.

BEZ235 study 1 (3.606 uM) / BEZ235 study 1 (IC50)

Relative Expression (log2-ratio):1.4382782
Number of Samples:4 / 4
Experimental BEZ235 study 1 (3.606 uM)
A2058 cells treated with 3.606 uM NVP-BEZ235 for 24hours. The concentration corresponding to the IC90 of BKM120. Cells were maintained in DMEM, high glucose, 10% FCS, 1% pyruvate, 2% glutamine. BEZ235 is a mTOR/PI3K inhibitor; alternative names: [NVP-BEZ235] ATC code:---
Control BEZ235 study 1 (IC50)
A2058 cells treated with NVP-BEZ235 for 24hours at an IC50 concentration. Concentration of IC50 was judged by reduction of pAkt levels (S473P-Akt inhibition) and the value is not clear from the article. Cells were maintained in DMEM, high glucose, 10% FCS, 1% pyruvate, 2% glutamine. BEZ235 is a mTOR/PI3K inhibitor; alternative names: [NVP-BEZ235] ATC code:---

RAF1 depletion study 2 / normal SW-620 cell sample

Relative Expression (log2-ratio):1.4194221
Number of Samples:6 / 3
Experimental RAF1 depletion study 2
RNAi-mediated gene knockdown of RAF1 in colorectal cancer cell line SW-620.
Control normal SW-620 cell sample
Non-transduced SW-620 colorectal cell line sample.

RAF1 depletion study 2 / mock transfected SW-620 cell sample

Relative Expression (log2-ratio):1.3933067
Number of Samples:6 / 6
Experimental RAF1 depletion study 2
RNAi-mediated gene knockdown of RAF1 in colorectal cancer cell line SW-620.
Control mock transfected SW-620 cell sample
SW-620 colorectal cell line sample transduced with non-targeting pLKO_NonTarget vector.