TOP TEN perturbations for NM_000257 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000257
Selected probe(set): 216265_x_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000257 (216265_x_at) across 5339 perturbations tested by GENEVESTIGATOR:

basal cell carcinoma study 3 / normal epidermal keratinocytes

Relative Expression (log2-ratio):2.8255816
Number of Samples:4 / 2
Experimental basal cell carcinoma study 3
Primary tumor tissue from the eyelid of patients with basal cell carcinoma (BCC).
Control normal epidermal keratinocytes
Normal human epidermal keratinocytes (NHEK) (Kurabo Ind., Ltd., Osaka, Japan) cultured in HuMedia-KB2 medium at 37?C in humidified air containing 5% CO2.

rheumatoid arthritis study 27 / normal synovial membrane tissue

Relative Expression (log2-ratio):-2.5892467
Number of Samples:16 / 7
Experimental rheumatoid arthritis study 27
Synovial membrane samples from end-stage rheumatoid arthritis patients undergoing surgery.
Control normal synovial membrane tissue
Synovial membrane samples obtained by fine-needle arthroscopy from healthy subjects.

kidney transplantation study 9 (late) / normal kidney transplant

Relative Expression (log2-ratio):1.8596764
Number of Samples:2 / 13
Experimental kidney transplantation study 9 (late)
Human renal allograft biopsies from deceased donors obtained 24 months after transplantation.
Control normal kidney transplant
Human renal allograft biopsies from deceased donors obtained at implantation prior to revascularization.

oral tongue squamous cell carcinoma study 1 / normal tongue squamous cell sample

Relative Expression (log2-ratio):-1.3077459
Number of Samples:25 / 12
Experimental oral tongue squamous cell carcinoma study 1
Tongue squamous cells of Oral Tongue Squamous Cell Carcinoma (OTSCC) patients.
Control normal tongue squamous cell sample
Tongue squamous cells from control subjects.

stem cell differentiation study 41 (hES-T3 EB) / undifferentiated hES-T3 cell sample

Relative Expression (log2-ratio):1.274333
Number of Samples:2 / 3
Experimental stem cell differentiation study 41 (hES-T3 EB)
Sample of embryonic bodies (EB) differentiated from human embryonic stem cells T3 with female karyotype.
Control undifferentiated hES-T3 cell sample
Undifferentiated human embryonic stem cells T3.

myotonic dystrophy study 2 (DM2) / normal skeletal muscle tissue

Relative Expression (log2-ratio):1.2514992
Number of Samples:20 / 6
Experimental myotonic dystrophy study 2 (DM2)
Muscle biopsies from patients with myotonic dystrophy type 2 (DM2). The disease was diagnosed by DNA mutation testing.
Control normal skeletal muscle tissue
Muscle biopsies from normal individuals.

embryonic development study 1 (7wk) / embryonic development study 1 (4wk)

Relative Expression (log2-ratio):-1.1713486
Number of Samples:3 / 3
Experimental embryonic development study 1 (7wk)
Human embryos at 7th week after fertilization. Embryos were obtained after therapeutic termination of pregnancy with mifepristone.
Control embryonic development study 1 (4wk)
Human embryos at 4th week after fertilization. Embryos were obtained after therapeutic termination of pregnancy with mifepristone.

brefeldin A study 1 (0.5ug/ml; p53HCT116) / untreated p53HCT116 cell sample

Relative Expression (log2-ratio):-1.0691633
Number of Samples:2 / 3
Experimental brefeldin A study 1 (0.5ug/ml; p53HCT116)
Derived human colon carcinoma cell line p53HCT116 with knockout gene for p53 was treated with 0.5 ug/ml brefeldin-A for 24 hours in McCOYs 5A medium supplemented with 10% heat inactivated FBS. ATC code:---
Control untreated p53HCT116 cell sample
Derived human colon carcinoma cell line p53HCT116 with knockout gene for p53 was grown in McCOYs 5A medium supplemented with 10% heat inactivated FBS.

brefeldin A study 1 (0.5ug/ml; HCT 116 DICER1(-/-)) / untreated HCT 116 DICER1(-/-) cell sample

Relative Expression (log2-ratio):-1.0096483
Number of Samples:3 / 3
Experimental brefeldin A study 1 (0.5ug/ml; HCT 116 DICER1(-/-))
Derived human colon carcinoma cell line HCT 116 DICER1(-/-) with knockout DICER gene in exon 5 was treated with 0.5 ug/ml brefeldin-A for 24 hours in McCOYs 5A medium supplemented with 10% heat inactivated FBS. ATC code:---
Control untreated HCT 116 DICER1(-/-) cell sample
Derived human colon carcinoma cell line HCT 116 DICER1(-/-) with knockout DICER gene in exon 5 by was grown in McCOYs 5A medium supplemented with 10% heat inactivated FBS.

glioma study 16 (oligodendroglioma) / normal brain tissue

Relative Expression (log2-ratio):0.95612526
Number of Samples:7 / 2
Experimental glioma study 16 (oligodendroglioma)
Primary oligodendroglioma tissues obtained from the operating room. Tumors were diagnosed and graded according to the current WHO classification (grade OGII-III).
Control normal brain tissue
Normal brain tissue sample from healthy donors.