TOP TEN perturbations for NM_000274 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000274
Selected probe(set): 201599_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000274 (201599_at) across 5339 perturbations tested by GENEVESTIGATOR:

hepatocyte (ESC) / HepaRG

Relative Expression (log2-ratio):9.229578
Number of Samples:8 / 12
Experimental hepatocyte (ESC)
Hepatocyte-like cells differentiated from embryonic stem cells (ESC)
Control HepaRG
Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code:

Hep-G2 / HepaRG

Relative Expression (log2-ratio):7.962359
Number of Samples:9 / 12
Experimental Hep-G2
Human primary cancer cell line derived from the liver of a patient with hepatocellular carcinoma. Synonyms:HEP-G2; Hep G2; HEP G2; HepG2; HEPG2 Cellosaurus code:
Control HepaRG
Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code:

HCC study 9 (alcohol; HCV) / normal liver tissue

Relative Expression (log2-ratio):-4.548155
Number of Samples:4 / 10
Experimental HCC study 9 (alcohol; HCV)
Liver tissue biopsy sample from patients with alcohol abuse and Hepatitis C infection related hepatocellular carcinoma (HCC) after resection.
Control normal liver tissue
Normal, non-tumor liver tissue.

HCC study 9 (alcohol; HBV) / normal liver tissue

Relative Expression (log2-ratio):-4.5313597
Number of Samples:3 / 10
Experimental HCC study 9 (alcohol; HBV)
Liver tissue biopsy sample from patients with alcohol abuse and Hepatitis B infection related hepatocellular carcinoma (HCC) after resection.
Control normal liver tissue
Normal, non-tumor liver tissue.

HCC study 9 (alcohol) / normal liver tissue

Relative Expression (log2-ratio):-3.8718948
Number of Samples:24 / 10
Experimental HCC study 9 (alcohol)
Liver tissue biopsy sample from patients with alcohol abuse related hepatocellular carcinoma (HCC) after resection.
Control normal liver tissue
Normal, non-tumor liver tissue.

HCC study 9 (metabolic) / normal liver tissue

Relative Expression (log2-ratio):-3.851201
Number of Samples:4 / 10
Experimental HCC study 9 (metabolic)
Liver tissue biopsy sample from patients with metabolism associated hepatocellular carcinoma (HCC) after resection.
Control normal liver tissue
Normal, non-tumor liver tissue.

HCC study 9 (HBV; HCV) / normal liver tissue

Relative Expression (log2-ratio):-3.8256636
Number of Samples:2 / 10
Experimental HCC study 9 (HBV; HCV)
Liver tissue biopsy sample from patients with Hepatitis B and C infection related hepatocellular carcinoma (HCC) after resection.
Control normal liver tissue
Normal, non-tumor liver tissue.

HCC study 9 (HBV) / normal liver tissue

Relative Expression (log2-ratio):-3.7557526
Number of Samples:10 / 10
Experimental HCC study 9 (HBV)
Liver tissue biopsy sample from patients with Hepatitis B infection related hepatocellular carcinoma (HCC) after resection.
Control normal liver tissue
Normal, non-tumor liver tissue.

HCC study 9 (HCV) / normal liver tissue

Relative Expression (log2-ratio):-3.4630919
Number of Samples:9 / 10
Experimental HCC study 9 (HCV)
Liver tissue biopsy sample from patients with Hepatitis C infection related hepatocellular carcinoma (HCC) after resection.
Control normal liver tissue
Normal, non-tumor liver tissue.

HCC study 18 (very advanced) / HCC study 18 (very early)

Relative Expression (log2-ratio):3.2777958
Number of Samples:3 / 5
Experimental HCC study 18 (very advanced)
Tumor tissue samples obtained from liver of patients with very advanced hepatocellular carcinoma (HCC) undergoing resection or liver transplantation. Very advanced HCC cases included moderately to poorly differentiated tumors with macrovascular invasion or diffuse liver involvement. Patients positive for HBV markers, with history of alcohol consumption, nonalcoholic steatohepatitis, hemochromatosis, other chronic liver diseases or prior locoregional treatment were excluded.
Control HCC study 18 (very early)
Tumor tissue samples obtained from liver of patients with very early hepatocellular carcinoma (HCC) undergoing resection or liver transplantation. Very early HCC cases included well-differentiated tumors measuring ?2 cm in diameter with no vascular invasion/satellites (size range: 8-20 mm). Patients positive for HBV markers, with history of alcohol consumption, nonalcoholic steatohepatitis, hemochromatosis, other chronic liver diseases or prior locoregional treatment were excluded.