TOP TEN perturbations for NM_000287 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000287
Selected probe(set): 204545_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000287 (204545_at) across 5392 perturbations tested by GENEVESTIGATOR:

glioma study 16 (LN-18) / normal astrocyte sample

Relative Expression (log2-ratio):3.4389553
Number of Samples:2 / 3
Experimental glioma study 16 (LN-18)
Human glioma cell line LN018 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

glioma study 16 (LN-319) / normal astrocyte sample

Relative Expression (log2-ratio):3.1252775
Number of Samples:2 / 3
Experimental glioma study 16 (LN-319)
Human glioma cell line LN319 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37?C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

glioma study 16 (LN-215) / normal astrocyte sample

Relative Expression (log2-ratio):2.4975853
Number of Samples:2 / 3
Experimental glioma study 16 (LN-215)
Human glioma cell line LN215 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37?C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

Treg activation study 1 (300min) / unstimulated regulatory T-cell sample

Relative Expression (log2-ratio):-2.0146732
Number of Samples:2 / 2
Experimental Treg activation study 1 (300min)
Regulatory T-cells were stimulated for 300min with anti-CD3/anti-CD28/IL-2 (100U/ml). Treg were sorted as CD4+ CD25high cells from peripheral blood of healthy donors.
Control unstimulated regulatory T-cell sample
Unstimulated regulatory T-cell sample derived from sorted CD4+ CD25high cells from peripheral blood of healthy donors.

DMNQ study 2 (15uM) / DMNQ study 1 (15uM)

Relative Expression (log2-ratio):1.9890814
Number of Samples:3 / 3
Experimental DMNQ study 2 (15uM)
Bronchial epithelial cell line derived from cystic fibrosis patient (CuFi-1) treated for 24 hours with DMNQ (15 uM), an inducer of oxidative stress. Cells were coated on collagen plastic dishes and cultured under air-liquid conditions in serum-free bronchial epithelial cell growth medium (with supplements). At the time of experiment cells were at passage 14. ATC code:---
Control DMNQ study 1 (15uM)
Bronchial epithelial cell line derived from healthy donor (NuLi-1) treated for 24 hours with DMNQ (15 uM), an inducer of oxidative stress. Cells were coated on collagen plastic dishes and cultured under air-liquid conditions in serum-free bronchial epithelial cell growth medium (with supplements). At the time of experiment cells were at passage 14. ATC code:---

Sjogren's syndrome study 1 (advanced) / normal minor salivary gland tissue

Relative Expression (log2-ratio):-1.9051571
Number of Samples:2 / 4
Experimental Sjogren's syndrome study 1 (advanced)
Whole minor salivary gland samples of patients with advanced Sjogren's syndrome.
Control normal minor salivary gland tissue
Whole minor salivary gland samples from non-Sjogren's syndrome control subjects.

cystic fibrosis study 3 / untreated NuLi-1 cell sample

Relative Expression (log2-ratio):1.8687458
Number of Samples:3 / 3
Experimental cystic fibrosis study 3
Untreated bronchial epithelial cell line derived from cystic fibrosis patient (CuFi-1). Cells were coated on collagen plastic dishes and cultured under air-liquid conditions in serum-free bronchial epithelial cell growth medium (with supplements). At the time of experiment cells were at passage 14.
Control untreated NuLi-1 cell sample
Untreated bronchial epithelial cell line derived from healthy donor (NuLi-1). Cells were coated on collagen plastic dishes and cultured under air-liquid conditions in serum-free bronchial epithelial cell growth medium (with supplements). At the time of experiment cells were at passage 14.

glioma study 17 ( small cell glioblastoma; unsorted) / non-tumor cortical tissue

Relative Expression (log2-ratio):1.7931995
Number of Samples:2 / 4
Experimental glioma study 17 ( small cell glioblastoma; unsorted)
Brain cells isolated from high grade small cell glioblastoma (grade IV). Tumor tissue was dissociated using enzymatic treatment and all cells were used for RNA isolation. Patients were 56 ? 3 years old males.
Control non-tumor cortical tissue
Cortical tissue obtained from patients with epilepsy, but without any manifested brain cancer. The tissue was dissociated using enzymatic treatment, but all brain cell types were used for analyses.

autosomal dominant polycystic kidney disease study 1 (cystic tissue) / non-tumor kidney tissue

Relative Expression (log2-ratio):1.7481613
Number of Samples:4 / 3
Experimental autosomal dominant polycystic kidney disease study 1 (cystic tissue)
Cystic tissue samples from patients with autosomal dominant polycystic kidney disease (ADPKD). Tissue was derived after nephrectomy from renal cortices containing microscopic small cysts.
Control non-tumor kidney tissue
Histologically normal renal cortex tissue samples from nephrectomized kidneys from patients with isolated renal cell carcinoma.

JIA study 4 / normal PBMC sample

Relative Expression (log2-ratio):-1.7288675
Number of Samples:3 / 22
Experimental JIA study 4
Peripheral blood mononuclear cell (PBMC) samples from children with juvenile idiopathic arthritis (JIA).
Control normal PBMC sample
Peripheral blood mononuclear cell (PBMC) samples from healthy children.