TOP TEN perturbations for NM_000292 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000292
Selected probe(set): 209439_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000292 (209439_s_at) across 5339 perturbations tested by GENEVESTIGATOR:

renal cell carcinoma study 1 (prim. tumor) / adjacent kidney tissue

Relative Expression (log2-ratio):2.4505787
Number of Samples:3 / 3
Experimental renal cell carcinoma study 1 (prim. tumor)
Tumor tissue from the primary tumor of patients with renal cell carcinoma (RCC).
Control adjacent kidney tissue
Histologically normal tissue from an unaffected site (renal tubules) of patients with renal cell carcinoma (RCC) of the clear cell type.

renal cell carcinoma study 1 (metastasis) / adjacent kidney tissue

Relative Expression (log2-ratio):2.2031221
Number of Samples:3 / 3
Experimental renal cell carcinoma study 1 (metastasis)
Tumor tissue from metastases of patients with renal cell carcinoma (RCC).
Control adjacent kidney tissue
Histologically normal tissue from an unaffected site (renal tubules) of patients with renal cell carcinoma (RCC) of the clear cell type.

clear cell renal cell carcinoma study 4 (stage 2) / normal kidney tissue

Relative Expression (log2-ratio):2.0462284
Number of Samples:19 / 69
Experimental clear cell renal cell carcinoma study 4 (stage 2)
Primary tumor tissue from patients with stage 2 clear cell renal cell carcinoma (ccRCC).
Control normal kidney tissue
Normal kidney tissue samples obtained from healthy individuals.

clear cell renal cell carcinoma study 4 (stage 3) / normal kidney tissue

Relative Expression (log2-ratio):1.9888678
Number of Samples:14 / 69
Experimental clear cell renal cell carcinoma study 4 (stage 3)
Primary tumor tissue from patients with stage 3 clear cell renal cell carcinoma (ccRCC).
Control normal kidney tissue
Normal kidney tissue samples obtained from healthy individuals.

renal cell carcinoma study 4 / normal kidney tissue

Relative Expression (log2-ratio):1.8987713
Number of Samples:26 / 3
Experimental renal cell carcinoma study 4
Tumor tissue samples from the kidney of patients with renal cell carcinoma (RCC).
Control normal kidney tissue
Normal adult kidney tissue samples.

aflatoxin B1 study 1 (24h) / vehicle (DMSO) treated HepG2 cell sample

Relative Expression (log2-ratio):-1.8304453
Number of Samples:3 / 7
Experimental aflatoxin B1 study 1 (24h)
HepG2 cells exposed to 1?M aflatoxin B1 in DMSO solvent for 12 hours. ATC code:---
Control vehicle (DMSO) treated HepG2 cell sample
HepG2 cells exposed to DMSO solvent for 24 hours.

glioma study 16 (LN-319) / normal astrocyte sample

Relative Expression (log2-ratio):1.801034
Number of Samples:2 / 3
Experimental glioma study 16 (LN-319)
Human glioma cell line LN319 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37?C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

clear cell renal cell carcinoma study 4 (stage 4) / normal kidney tissue

Relative Expression (log2-ratio):1.7824917
Number of Samples:14 / 69
Experimental clear cell renal cell carcinoma study 4 (stage 4)
Primary tumor tissue from patients with stage 4 clear cell renal cell carcinoma (ccRCC).
Control normal kidney tissue
Normal kidney tissue samples obtained from healthy individuals.

azathioprine study 8 (48h) / vehicle (DMSO) treated HepG2 cell sample

Relative Expression (log2-ratio):-1.7707644
Number of Samples:2 / 19
Experimental azathioprine study 8 (48h)
HepG2 cells exposed to 250?M azathioprine in DMSO solvent for 48 hours. ATC code:
Control vehicle (DMSO) treated HepG2 cell sample
HepG2 cells exposed to DMSO solvent for 48 hours.

clear cell renal cell carcinoma study 3 (non-obese; smoker) / smoking study 71 (non-obese)

Relative Expression (log2-ratio):1.7337589
Number of Samples:16 / 15
Experimental clear cell renal cell carcinoma study 3 (non-obese; smoker)
Tumor tissue from patients with clear cell renal cell carcinoma (ccRCC). Patients were smokers and had a BMI < 30 kg/m2. Patients with late T4 stage and grade 4 tumors were excluded.
Control smoking study 71 (non-obese)
Kidney tissue samples from non-obese smokers with a BMI < 30 kg/m2 and pack-years > 20.