TOP TEN perturbations for NM_000299 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000299
Selected probe(set): 221854_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000299 (221854_at) across 5392 perturbations tested by GENEVESTIGATOR:

non-small cell lung cancer study 8 (squamous cell carcinoma) / adjacent lung tissue

Relative Expression (log2-ratio):5.5482025
Number of Samples:27 / 65
Experimental non-small cell lung cancer study 8 (squamous cell carcinoma)
Primary tumor tissue sample obtained from the lung of patients squamous cell carcinoma.
Control adjacent lung tissue
Histological normal lung tissue samples from patients with lung cancer.

esophageal adenocarcinoma study 1 / normal esophageal epithelium sample

Relative Expression (log2-ratio):-5.5472755
Number of Samples:20 / 18
Experimental esophageal adenocarcinoma study 1
Esophageal adenocarcinoma (EAC) samples of affected epithelium recovered by laser capture microdissection technique.
Control normal esophageal epithelium sample
Histologically normal esophageal squamous cell epithelium biopsy samples from patients that were investigated for esophageal pain, but diagnosed as healthy.

TC-71 / TC-32

Relative Expression (log2-ratio):5.3721523
Number of Samples:6 / 6
Experimental TC-71
Human primary cancer cell line derived from the humerus of a patient with Ewing sarcoma. Synonyms:TC71; GM11654 Cellosaurus code:
Control TC-32
Human primary cancer cell line derived from the unspecified origin of a patient with Ewing?s sarcoma. Synonyms:TC32 Cellosaurus code:

esophageal squamous cell carcinoma study 1 / esophageal adenocarcinoma study 1

Relative Expression (log2-ratio):5.1341124
Number of Samples:8 / 20
Experimental esophageal squamous cell carcinoma study 1
Esophageal squamous cell carcinoma (ESCC) biopsy samples from chemotherapy-naive patients with histological grading G1 (well differentiated) and UICC stage II and III, which undergone esophagectomy.
Control esophageal adenocarcinoma study 1
Esophageal adenocarcinoma (EAC) samples of affected epithelium recovered by laser capture microdissection technique.

lung squamous cell carcinoma study 1 / normal lung tissue

Relative Expression (log2-ratio):5.0401707
Number of Samples:31 / 44
Experimental lung squamous cell carcinoma study 1
Primary lung squamous cell carcinoma samples of a patient with non-small cell lung cancer.
Control normal lung tissue
Histologically normal lung tissue.

non-small cell lung cancer study 8 (squamous cell carcinoma) / non-small cell lung cancer study 8 (large cell carcinoma)

Relative Expression (log2-ratio):4.95529
Number of Samples:27 / 18
Experimental non-small cell lung cancer study 8 (squamous cell carcinoma)
Primary tumor tissue sample obtained from the lung of patients squamous cell carcinoma.
Control non-small cell lung cancer study 8 (large cell carcinoma)
Primary tumor tissue sample obtained from the lung of patients large cell carcinoma.

non-small cell lung cancer study 8 (squamous cell carcinoma) / non-small cell lung cancer study 8 (adenocarcinoma)

Relative Expression (log2-ratio):4.7809153
Number of Samples:27 / 45
Experimental non-small cell lung cancer study 8 (squamous cell carcinoma)
Primary tumor tissue sample obtained from the lung of patients squamous cell carcinoma.
Control non-small cell lung cancer study 8 (adenocarcinoma)
Primary tumor tissue sample obtained from the lung of patients adenocarcinoma.

Langerhans cell histiocytosis study 2 (multifocal) / normal epidermal Langerhans cell sample

Relative Expression (log2-ratio):-4.682229
Number of Samples:2 / 10
Experimental Langerhans cell histiocytosis study 2 (multifocal)
Langerhans cell histiocytes (LCH, CD207+) samples isolated from LCH lesions of patients with multifocal (bone, skin lesions) disease.
Control normal epidermal Langerhans cell sample
Normal epidermal Langerhans cells (CD207+) were isolated from skin of children donors (age < 18 years). The Langerhans cells were isolated from presumably healthy tissue.

Barrett's esophagus study 3 / normal esophageal epithelium sample

Relative Expression (log2-ratio):-4.643238
Number of Samples:17 / 18
Experimental Barrett's esophagus study 3
Esophageal epithelium samples from areas with Barrett's esophagus metaplasia which were recovered by laser capture microdissection.
Control normal esophageal epithelium sample
Histologically normal esophageal squamous cell epithelium biopsy samples from patients that were investigated for esophageal pain, but diagnosed as healthy.

Merkel cell carcinoma study 3 (metastatic) / normal skin tissue

Relative Expression (log2-ratio):-4.5931835
Number of Samples:22 / 64
Experimental Merkel cell carcinoma study 3 (metastatic)
Metastatic tumor tissue from different metastatic sites (skin, lymph node, parotid gland) of patients with Merkel cell carcinoma of the skin.
Control normal skin tissue
Normal skin samples from healthy donors.