TOP TEN perturbations for NM_000315 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000315
Selected probe(set): 206977_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000315 (206977_at) across 5392 perturbations tested by GENEVESTIGATOR:

retina pigment epithelium study 1 (adult) / retina pigment epithelium study 1 (fetal)

Relative Expression (log2-ratio):-5.606806
Number of Samples:2 / 6
Experimental retina pigment epithelium study 1 (adult)
Postmortem human native retina pigment epithelium samples from adult individuals.
Control retina pigment epithelium study 1 (fetal)
Human native fetal retina pigment epithelium samples obtained at gestation age between week 16-18.

retina pigment epithelium study 2 (fetal) / retina pigment epithelium study 1 (fetal)

Relative Expression (log2-ratio):-4.650243
Number of Samples:12 / 6
Experimental retina pigment epithelium study 2 (fetal)
Human cultured fetal retina pigment epithelium samples obtained at gestation age between week 16-18.
Control retina pigment epithelium study 1 (fetal)
Human native fetal retina pigment epithelium samples obtained at gestation age between week 16-18.

KLF5 depletion study 1 (siRNA; YCC-3) / GATA6 depletion study 1 (siRNA; YCC-3)

Relative Expression (log2-ratio):1.5147147
Number of Samples:3 / 3
Experimental KLF5 depletion study 1 (siRNA; YCC-3)
Gastric adenocarcinoma cell line YCC-3 transfected with KLF5 siRNA. YCC-3 cell line was grown in MEM, 10%FBS, 1X NEAA, 1X L-glutamine, Pen-strep. Abbreviation: KLF5- Kr?ppel-like factor 5.
Control GATA6 depletion study 1 (siRNA; YCC-3)
Gastric adenocarcinoma cell line YCC-3 transfected with GATA6 siRNA. YCC-3 cell line was grown in MEM, 10%FBS, 1X NEAA, 1X L-glutamine, Pen-strep.

KLF5 depletion study 1 (siRNA; YCC-3) / GATA4 depletion study 1 (siRNA; YCC-3)

Relative Expression (log2-ratio):1.5128951
Number of Samples:3 / 3
Experimental KLF5 depletion study 1 (siRNA; YCC-3)
Gastric adenocarcinoma cell line YCC-3 transfected with KLF5 siRNA. YCC-3 cell line was grown in MEM, 10%FBS, 1X NEAA, 1X L-glutamine, Pen-strep. Abbreviation: KLF5- Kr?ppel-like factor 5.
Control GATA4 depletion study 1 (siRNA; YCC-3)
Gastric adenocarcinoma cell line YCC-3 transfected with GATA4 siRNA. YCC-3 cell line was grown in MEM, 10%FBS, 1X NEAA, 1X L-glutamine, Pen-strep.

KLF5 depletion study 1 (siRNA; YCC-3) / mock transfected YCC-3 cell sample

Relative Expression (log2-ratio):1.3980575
Number of Samples:3 / 3
Experimental KLF5 depletion study 1 (siRNA; YCC-3)
Gastric adenocarcinoma cell line YCC-3 transfected with KLF5 siRNA. YCC-3 cell line was grown in MEM, 10%FBS, 1X NEAA, 1X L-glutamine, Pen-strep. Abbreviation: KLF5- Kr?ppel-like factor 5.
Control mock transfected YCC-3 cell sample
Gastric adenocarcinoma cell line YCC-3 transfected with control siRNA. YCC-3 cell line was grown in MEM, 10%FBS, 1X NEAA, 1X L-glutamine, Pen-strep.

atypical teratoid/rhabdoid tumor study 1 / medulloblastoma study 1

Relative Expression (log2-ratio):1.184155
Number of Samples:20 / 17
Experimental atypical teratoid/rhabdoid tumor study 1
Primary tumor tissue sample from the brain of pediatric patients with atypical teratoid/rhabdoid tumor (AT/RT).
Control medulloblastoma study 1
Primary tumor tissue sample from the infratentorial brain of pediatric patients with classical medulloblastoma.

glioma study 17 ( small cell glioblastoma; unsorted) / non-tumor cortical tissue

Relative Expression (log2-ratio):-0.64165306
Number of Samples:2 / 4
Experimental glioma study 17 ( small cell glioblastoma; unsorted)
Brain cells isolated from high grade small cell glioblastoma (grade IV). Tumor tissue was dissociated using enzymatic treatment and all cells were used for RNA isolation. Patients were 56 ? 3 years old males.
Control non-tumor cortical tissue
Cortical tissue obtained from patients with epilepsy, but without any manifested brain cancer. The tissue was dissociated using enzymatic treatment, but all brain cell types were used for analyses.

glioma study 17 (glioblastoma; unsorted) / non-tumor cortical tissue

Relative Expression (log2-ratio):-0.61243296
Number of Samples:2 / 4
Experimental glioma study 17 (glioblastoma; unsorted)
Brain cells isolated from high grade glioblastoma (grade IV). Tumor tissue was dissociated using enzymatic treatment and all cells were used for RNA isolation.
Control non-tumor cortical tissue
Cortical tissue obtained from patients with epilepsy, but without any manifested brain cancer. The tissue was dissociated using enzymatic treatment, but all brain cell types were used for analyses.

CH5183284 study 1 (MFE-296) / vehicle (DMSO) treated MFE-296 cell sample

Relative Expression (log2-ratio):-0.3926878
Number of Samples:2 / 2
Experimental CH5183284 study 1 (MFE-296)
Human endometrial cell line MFE-296 treated with 1 uM of FGFR inhibitor CH5183284 for 24 hours. ATC code:---
Control vehicle (DMSO) treated MFE-296 cell sample
Human endometrial cell line MFE-296 treated with 0.1% DMSO for 24 hours.

juvenile psoriatic arthritis study 1 / juvenile enthesitis related arthritis study 1 (ERA)

Relative Expression (log2-ratio):0.37767887
Number of Samples:2 / 26
Experimental juvenile psoriatic arthritis study 1
Peripheral blood mononuclear cell (PBMC) samples from children with juvenile psoriatic arthritis. All patients were free of disease modifying antirheumatic drugs.
Control juvenile enthesitis related arthritis study 1 (ERA)
Peripheral blood mononuclear cell (PBMC) samples from children with enthesitis related arthritis (ERA). All patients were free of disease modifying antirheumatic drugs.