TOP TEN perturbations for NM_000322 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000322
Selected probe(set): 206625_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000322 (206625_at) across 5392 perturbations tested by GENEVESTIGATOR:

basal cell carcinoma study 3 / normal epidermal keratinocytes

Relative Expression (log2-ratio):1.9562788
Number of Samples:4 / 2
Experimental basal cell carcinoma study 3
Primary tumor tissue from the eyelid of patients with basal cell carcinoma (BCC).
Control normal epidermal keratinocytes
Normal human epidermal keratinocytes (NHEK) (Kurabo Ind., Ltd., Osaka, Japan) cultured in HuMedia-KB2 medium at 37?C in humidified air containing 5% CO2.

retina pigment epithelium study 1 (adult) / retina pigment epithelium study 1 (fetal)

Relative Expression (log2-ratio):1.7709951
Number of Samples:2 / 6
Experimental retina pigment epithelium study 1 (adult)
Postmortem human native retina pigment epithelium samples from adult individuals.
Control retina pigment epithelium study 1 (fetal)
Human native fetal retina pigment epithelium samples obtained at gestation age between week 16-18.

atopic dermatitis study 12 (lesional; children) / normal skin tissue (children)

Relative Expression (log2-ratio):-1.7398939
Number of Samples:18 / 15
Experimental atopic dermatitis study 12 (lesional; children)
Lesional popliteal skin biopsy samples from pediatric patients (age range 3 months-5 years) with early-onset atopic dermatitis. All biopsy specimens were from chronic lesions present for more than 72 hours. All patients had moderate-to-severe disease with recent-onset (within the previous 6 months). Systemic immunosuppressants within the past 4 weeks, topical steroids or immunomodulators within 1 week, or moisturizers within 12 hours before evaluation were restricted. Patients with active skin infections were excluded.
Control normal skin tissue (children)
Skin biopsy samples from healthy children (age range 4 months ? 3 years) without personal/familial atopy.

prostate cancer study 8 (p. canc) / prostate cancer study 8 (ptasc)

Relative Expression (log2-ratio):-1.5598269
Number of Samples:3 / 2
Experimental prostate cancer study 8 (p. canc)
CD26+ FACS sorted prostate neoplasm cell (p. canc) samples from patients with primary prostate cancer collected after radical prostatectomy.
Control prostate cancer study 8 (ptasc)
CD90+ FACS sorted prostate tumor-associated stromal cell (ptasc) samples from patients with primary prostate cancer collected after radical prostatectomy.

rhegmatogenous retinal detachment study 1 / normal retina tissue

Relative Expression (log2-ratio):-1.5486279
Number of Samples:19 / 17
Experimental rhegmatogenous retinal detachment study 1
Retina tissue samples from patients with retinal detachment obtained by vitrectomy.
Control normal retina tissue
Postmortem retina tissue samples from healthy patients without any diseases of the eye.

pancreatic cancer study 3 (ipmn) / normal pancreas tissue

Relative Expression (log2-ratio):-1.5467014
Number of Samples:3 / 6
Experimental pancreatic cancer study 3 (ipmn)
Intraductal papillary mucinous neoplasm from patients with pancreatic cancer.
Control normal pancreas tissue
Normal human pancreatic tissue.

rheumatoid arthritis study 37 (pbnkTC) / normal peripheral blood natural killer T-cell sample

Relative Expression (log2-ratio):1.3613005
Number of Samples:7 / 6
Experimental rheumatoid arthritis study 37 (pbnkTC)
Peripheral blood natural killer T-cell samples (pbnkTC) derived from patients with rheumatoid arthritis (RA). Some of the patients were assigned to the treatment with disease-modifying antirheumatic drugs (DMARDs) i.e. tocilizumab (TCZ) and/or infliximab (IFX) and/or methotrexat (MTX). Patients characteristics: age 55.71?22.01 year; 2 males and 5 females; RF positive 5 (71.4%); ACPA positive 5 (71.4%); CRP 2.18?2.00 mg/dl; ESR 81.71?37.95 mm/hr; DAS28-CRP 5.19?1.09; DAS28-ESR 6.27?1.11; SDAI 30.47?16.84; CDAI 28.29?15.86; HAQ-DI 1.12?0.79; TJC28 8.57?5.71; SJC28 8.29?6.82; Pain, VAS 63.57?20.14; Physician GA, VAS 49.29 ?29.95 mm; Subject GA, VAS 65.00?14.31 mm
Control normal peripheral blood natural killer T-cell sample
Peripheral blood natural killer T-cell samples derived from healthy control subjects who did not have autoimmune diseases or were not receiving any drugs. Donor characteristics: age 43.83?6.55 year.

strabismus study 1 / normal extraocular medial rectus muscle tissue

Relative Expression (log2-ratio):-1.3604164
Number of Samples:3 / 4
Experimental strabismus study 1
Human extraocular medial rectus muscle tissue sample obtained from patients with strabismus after strabismus correction surgery.
Control normal extraocular medial rectus muscle tissue
Postmortem human extraocular medial rectus tissue samples from healthy donors without any ophthalmologic disease.

glioma study 16 (oligodendroglioma) / normal brain tissue

Relative Expression (log2-ratio):-1.3559313
Number of Samples:7 / 2
Experimental glioma study 16 (oligodendroglioma)
Primary oligodendroglioma tissues obtained from the operating room. Tumors were diagnosed and graded according to the current WHO classification (grade OGII-III).
Control normal brain tissue
Normal brain tissue sample from healthy donors.

gonadotroph adenoma study 1 / normal pituitary gland tissue

Relative Expression (log2-ratio):-1.3487816
Number of Samples:7 / 8
Experimental gonadotroph adenoma study 1
Gonadotroph adenoma biopsy samples recovered during transsphenoidal surgery. The tumors were defined as demonstrating positive immunostaining for FSH, LH, or alpha subunit in greater than 5-10% of cells. Samples were scanned between 04/6/2004 - 15/4/2005.
Control normal pituitary gland tissue
Biopsy samples of healthy pituitary gland recovered post-mortem during autopsy within 2-18 hours of death. Cause of death were mostly various pulmonary or cardiovascular conditions.