TOP TEN perturbations for NM_000353 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000353
Selected probe(set): 206916_x_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000353 (206916_x_at) across 5392 perturbations tested by GENEVESTIGATOR:

caffeine study 2 (7500uM) / vehicle (medium) treated hepatocyte sample

Relative Expression (log2-ratio):4.1458673
Number of Samples:2 / 2
Experimental caffeine study 2 (7500uM)
Hepatocytes treated with compound: caffeine (7500uM; CHEMBL113) for 24 hours. ATC code:
Control vehicle (medium) treated hepatocyte sample
Hepatocytes treated with vehicle (medium) for 24 hours.

HCC study 9 (HBV; HCV) / normal liver tissue

Relative Expression (log2-ratio):-3.5530777
Number of Samples:2 / 10
Experimental HCC study 9 (HBV; HCV)
Liver tissue biopsy sample from patients with Hepatitis B and C infection related hepatocellular carcinoma (HCC) after resection.
Control normal liver tissue
Normal, non-tumor liver tissue.

HCC study 18 (very advanced) / dysplastic liver nodule study 1

Relative Expression (log2-ratio):-3.28121
Number of Samples:3 / 17
Experimental HCC study 18 (very advanced)
Tumor tissue samples obtained from liver of patients with very advanced hepatocellular carcinoma (HCC) undergoing resection or liver transplantation. Very advanced HCC cases included moderately to poorly differentiated tumors with macrovascular invasion or diffuse liver involvement. Patients positive for HBV markers, with history of alcohol consumption, nonalcoholic steatohepatitis, hemochromatosis, other chronic liver diseases or prior locoregional treatment were excluded.
Control dysplastic liver nodule study 1
Dysplastic nodule tissue samples obtained from liver of HCV infected patients undergoing resection or liver transplantation. Patients positive for HBV markers, with history of alcohol consumption, nonalcoholic steatohepatitis, hemochromatosis, other chronic liver diseases or prior locoregional treatment were excluded.

theophylline study 5 (10000uM) / vehicle (medium) treated hepatocyte sample

Relative Expression (log2-ratio):3.2277784
Number of Samples:2 / 2
Experimental theophylline study 5 (10000uM)
Hepatocytes treated with compound: theophylline (10000uM; CHEMBL190) for 24 hours. ATC code:
Control vehicle (medium) treated hepatocyte sample
Hepatocytes treated with vehicle (medium) for 24 hours.

HCC study 18 (very advanced) / hepatitis C study 10

Relative Expression (log2-ratio):-3.1798763
Number of Samples:3 / 13
Experimental HCC study 18 (very advanced)
Tumor tissue samples obtained from liver of patients with very advanced hepatocellular carcinoma (HCC) undergoing resection or liver transplantation. Very advanced HCC cases included moderately to poorly differentiated tumors with macrovascular invasion or diffuse liver involvement. Patients positive for HBV markers, with history of alcohol consumption, nonalcoholic steatohepatitis, hemochromatosis, other chronic liver diseases or prior locoregional treatment were excluded.
Control hepatitis C study 10
Cirrhotic tissue samples obtained from liver of HCV infected patients undergoing resection or liver transplantation. Ten out of 13 samples were obtained from patients with hepatocellular carcinoma. Patients positive for HBV markers, with history of alcohol consumption, nonalcoholic steatohepatitis, hemochromatosis, other chronic liver diseases or prior locoregional treatment were excluded.

HCC study 18 (very advanced) / normal liver tissue

Relative Expression (log2-ratio):-3.0309887
Number of Samples:3 / 10
Experimental HCC study 18 (very advanced)
Tumor tissue samples obtained from liver of patients with very advanced hepatocellular carcinoma (HCC) undergoing resection or liver transplantation. Very advanced HCC cases included moderately to poorly differentiated tumors with macrovascular invasion or diffuse liver involvement. Patients positive for HBV markers, with history of alcohol consumption, nonalcoholic steatohepatitis, hemochromatosis, other chronic liver diseases or prior locoregional treatment were excluded.
Control normal liver tissue
Normal liver tissue samples obtained from the healthy livers of patients undergoing resection for hepatic hemangioma, focal nodular hyperplasia, adenoma/cystadenoma, neuroendocrine tumor, and living donor liver transplantation.

HCC study 9 (alcohol; HCV) / HCC study 9 (HBV; HCV)

Relative Expression (log2-ratio):2.8298988
Number of Samples:4 / 2
Experimental HCC study 9 (alcohol; HCV)
Liver tissue biopsy sample from patients with alcohol abuse and Hepatitis C infection related hepatocellular carcinoma (HCC) after resection.
Control HCC study 9 (HBV; HCV)
Liver tissue biopsy sample from patients with Hepatitis B and C infection related hepatocellular carcinoma (HCC) after resection.

captopril study 5 (8000uM) / vehicle (medium) treated hepatocyte sample

Relative Expression (log2-ratio):2.10468
Number of Samples:2 / 2
Experimental captopril study 5 (8000uM)
Hepatocytes treated with compound: captopril (8000uM; CHEMBL1560) for 24 hours. ATC code:,
Control vehicle (medium) treated hepatocyte sample
Hepatocytes treated with vehicle (medium) for 24 hours.

HCC study 9 (HBV) / normal liver tissue

Relative Expression (log2-ratio):-2.0918703
Number of Samples:10 / 10
Experimental HCC study 9 (HBV)
Liver tissue biopsy sample from patients with Hepatitis B infection related hepatocellular carcinoma (HCC) after resection.
Control normal liver tissue
Normal, non-tumor liver tissue.

hepatocyte (ESC) / HepaRG

Relative Expression (log2-ratio):-2.0748816
Number of Samples:8 / 12
Experimental hepatocyte (ESC)
Hepatocyte-like cells differentiated from embryonic stem cells (ESC)
Control HepaRG
Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code: