TOP TEN perturbations for NM_000359 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000359
Selected probe(set): 206008_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000359 (206008_at) across 5392 perturbations tested by GENEVESTIGATOR:

esophageal adenocarcinoma study 1 / normal esophageal epithelium sample

Relative Expression (log2-ratio):-6.607299
Number of Samples:20 / 18
Experimental esophageal adenocarcinoma study 1
Esophageal adenocarcinoma (EAC) samples of affected epithelium recovered by laser capture microdissection technique.
Control normal esophageal epithelium sample
Histologically normal esophageal squamous cell epithelium biopsy samples from patients that were investigated for esophageal pain, but diagnosed as healthy.

Barrett's esophagus study 3 / normal esophageal epithelium sample

Relative Expression (log2-ratio):-5.2651834
Number of Samples:17 / 18
Experimental Barrett's esophagus study 3
Esophageal epithelium samples from areas with Barrett's esophagus metaplasia which were recovered by laser capture microdissection.
Control normal esophageal epithelium sample
Histologically normal esophageal squamous cell epithelium biopsy samples from patients that were investigated for esophageal pain, but diagnosed as healthy.

esophageal squamous cell carcinoma study 1 / normal esophageal epithelium sample

Relative Expression (log2-ratio):-4.981412
Number of Samples:8 / 18
Experimental esophageal squamous cell carcinoma study 1
Esophageal squamous cell carcinoma (ESCC) biopsy samples from chemotherapy-naive patients with histological grading G1 (well differentiated) and UICC stage II and III, which undergone esophagectomy.
Control normal esophageal epithelium sample
Histologically normal esophageal squamous cell epithelium biopsy samples from patients that were investigated for esophageal pain, but diagnosed as healthy.

brodalumab study 3 (intermediate) / untreated skin tissue (psoriasis)

Relative Expression (log2-ratio):-3.6313543
Number of Samples:8 / 2
Experimental brodalumab study 3 (intermediate)
Lesional skin punch biopsies derived from patients with psoriasis. The punch biopsy was obtained from active, lesional skin after treatment with 700mg brodalumab for 15 days. ATC code:---
Control untreated skin tissue (psoriasis)
Untreated lesional skin biopsy samples from patients with psoriasis.

Merkel cell carcinoma study 3 (primary) / skin squamous cell carcinoma study 6

Relative Expression (log2-ratio):-3.4834394
Number of Samples:38 / 4
Experimental Merkel cell carcinoma study 3 (primary)
Primary tumor tissue from the skin of patients with Merkel cell carcinoma.
Control skin squamous cell carcinoma study 6
Primary tumor tissue from the skin of patients with squamous cell carcinoma (SCC).

lactic acid study 1 (normoxia) / untreated breast epithelial cell sample

Relative Expression (log2-ratio):3.3165045
Number of Samples:3 / 3
Experimental lactic acid study 1 (normoxia)
Breast epithelial cells exposed to 25mM lactic acid of pH6.7 under normoxia. ATC code:
Control untreated breast epithelial cell sample
Breast epithelial cells in control media under normoxia.

brodalumab study 3 (late) / untreated skin tissue (psoriasis)

Relative Expression (log2-ratio):-3.2106285
Number of Samples:8 / 2
Experimental brodalumab study 3 (late)
Lesional skin punch biopsies derived from patients with psoriasis. The punch biopsy was obtained from active, lesional skin after treatment with 700mg brodalumab for 43 days. ATC code:---
Control untreated skin tissue (psoriasis)
Untreated lesional skin biopsy samples from patients with psoriasis.

skin transplantation study 1 (7d) / split-thickness skin grafting study 1

Relative Expression (log2-ratio):3.097598
Number of Samples:5 / 6
Experimental skin transplantation study 1 (7d)
Human skin punch biopsy from patients after skin grafting. Sample was taken at the site of re-epithelialization 7 days after surgery.
Control split-thickness skin grafting study 1
Skin punch biopsy from patients with skin injury (burn injury, congelation, wound, compartment syndrome) immediately after split-thickness skin grafting was done. Sample was taken from the acute wound after grafting.

brodalumab study 3 (late) / brodalumab study 1 (late)

Relative Expression (log2-ratio):-2.676897
Number of Samples:8 / 4
Experimental brodalumab study 3 (late)
Lesional skin punch biopsies derived from patients with psoriasis. The punch biopsy was obtained from active, lesional skin after treatment with 700mg brodalumab for 43 days. ATC code:---
Control brodalumab study 1 (late)
Lesional skin punch biopsies derived from patients with psoriasis. The punch biopsy was obtained from active, lesional skin after treatment with 140mg brodalumab for 43 days. ATC code:---

skin squamous cell carcinoma study 6 / basal cell carcinoma study 2

Relative Expression (log2-ratio):2.6702585
Number of Samples:4 / 2
Experimental skin squamous cell carcinoma study 6
Primary tumor tissue from the skin of patients with squamous cell carcinoma (SCC).
Control basal cell carcinoma study 2
Primary tumor tissue from the skin of patients with basal cell carcinoma (BCC).