TOP TEN perturbations for NM_000370 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000370
Selected probe(set): 210614_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000370 (210614_at) across 5392 perturbations tested by GENEVESTIGATOR:

4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone study 1 (7500 uM; HepaRG) / vehicle (DMSO) treated HepaRG cell sample

Relative Expression (log2-ratio):-3.3694143
Number of Samples:3 / 12
Experimental 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone study 1 (7500 uM; HepaRG)
HepaRG cells exposed to 7500 uM 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (dissolved in 0.5% v/v DMSO) for 72 hours. Cells were cultivated in DMSO-containing medium between days 13 - 19 to allow them to differentiate into hepatocyte-like cells and become fully functional. Chemical was added at day 19 of cultivation. Cells were treated with the IC10 determined by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test (number of replicates, n = 3). ATC code:---
Control vehicle (DMSO) treated HepaRG cell sample
HepaRG cells treated with vehicle (DMSO 0.5% v/v) for 72 hours. Firstly, cells were cultivated in DMSO-containing medium between days 13 - 19 to allow them to differentiate into hepatocyte-like cells and become fully functional. Then the vehicle was added.

hepatocyte (ESC) / HepaRG

Relative Expression (log2-ratio):-3.1547737
Number of Samples:8 / 12
Experimental hepatocyte (ESC)
Hepatocyte-like cells differentiated from embryonic stem cells (ESC)
Control HepaRG
Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code:

Hep-G2 / HepaRG

Relative Expression (log2-ratio):-2.7930574
Number of Samples:9 / 12
Experimental Hep-G2
Human primary cancer cell line derived from the liver of a patient with hepatocellular carcinoma. Synonyms:HEP-G2; Hep G2; HEP G2; HepG2; HEPG2 Cellosaurus code:
Control HepaRG
Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code:

omeprazole study 6 (600uM) / vehicle (DMSO) treated hepatocyte sample

Relative Expression (log2-ratio):-2.122158
Number of Samples:2 / 2
Experimental omeprazole study 6 (600uM)
Hepatocytes treated with compound: omeprazole (600uM; CHEMBL1503) for 24 hours. ATC code:
Control vehicle (DMSO) treated hepatocyte sample
Hepatocytes treated with vehicle (DMSO) for 24 hours.

HCC study 18 (very advanced) / normal liver tissue

Relative Expression (log2-ratio):-2.0302343
Number of Samples:3 / 10
Experimental HCC study 18 (very advanced)
Tumor tissue samples obtained from liver of patients with very advanced hepatocellular carcinoma (HCC) undergoing resection or liver transplantation. Very advanced HCC cases included moderately to poorly differentiated tumors with macrovascular invasion or diffuse liver involvement. Patients positive for HBV markers, with history of alcohol consumption, nonalcoholic steatohepatitis, hemochromatosis, other chronic liver diseases or prior locoregional treatment were excluded.
Control normal liver tissue
Normal liver tissue samples obtained from the healthy livers of patients undergoing resection for hepatic hemangioma, focal nodular hyperplasia, adenoma/cystadenoma, neuroendocrine tumor, and living donor liver transplantation.

CH5183284 study 1 (NCI-H520) / vehicle (DMSO) treated NCI-H520 cell sample

Relative Expression (log2-ratio):1.6081982
Number of Samples:2 / 2
Experimental CH5183284 study 1 (NCI-H520)
Human lung cancer cell line NCI-H520 treated with 1 uM of FGFR inhibitor CH5183284 for 24 hours. ATC code:---
Control vehicle (DMSO) treated NCI-H520 cell sample
Human lung cancer cell line NCI-H520 treated with 0.1% DMSO for 24 hours.

diazepam study 3 (250uM) / vehicle (DMSO) treated hepatocyte sample

Relative Expression (log2-ratio):-1.5950775
Number of Samples:2 / 2
Experimental diazepam study 3 (250uM)
Hepatocytes treated with compound: diazepam (250uM; CHEMBL12) for 24 hours. ATC code:
Control vehicle (DMSO) treated hepatocyte sample
Hepatocytes treated with vehicle (DMSO) for 24 hours.

propylthiouracil study 6 (4000uM) / vehicle (medium) treated hepatocyte sample

Relative Expression (log2-ratio):-1.5076332
Number of Samples:2 / 2
Experimental propylthiouracil study 6 (4000uM)
Hepatocytes treated with compound: propylthiouracil (4000uM; CHEMBL1518) for 24 hours. ATC code:
Control vehicle (medium) treated hepatocyte sample
Hepatocytes treated with vehicle (medium) for 24 hours.

HCC study 9 (alcohol; HBV) / HCC study 9 (alcohol)

Relative Expression (log2-ratio):1.4911385
Number of Samples:3 / 24
Experimental HCC study 9 (alcohol; HBV)
Liver tissue biopsy sample from patients with alcohol abuse and Hepatitis B infection related hepatocellular carcinoma (HCC) after resection.
Control HCC study 9 (alcohol)
Liver tissue biopsy sample from patients with alcohol abuse related hepatocellular carcinoma (HCC) after resection.

danazol study 5 (35uM) / vehicle (DMSO) treated hepatocyte sample

Relative Expression (log2-ratio):-1.4574633
Number of Samples:2 / 2
Experimental danazol study 5 (35uM)
Hepatocytes treated with compound: danazol (35uM; CHEMBL1479) for 24 hours. ATC code:
Control vehicle (DMSO) treated hepatocyte sample
Hepatocytes treated with vehicle (DMSO) for 24 hours.