TOP TEN perturbations for NM_000402 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000402
Selected probe(set): 202275_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000402 (202275_at) across 5339 perturbations tested by GENEVESTIGATOR:

diazepam study 3 (250uM) / vehicle (DMSO) treated hepatocyte sample

Relative Expression (log2-ratio):4.7047796
Number of Samples:2 / 2
Experimental diazepam study 3 (250uM)
Hepatocytes treated with compound: diazepam (250uM; CHEMBL12) for 24 hours. ATC code:
Control vehicle (DMSO) treated hepatocyte sample
Hepatocytes treated with vehicle (DMSO) for 24 hours.

valproic acid study 25 (5000uM) / vehicle (medium) treated hepatocyte sample

Relative Expression (log2-ratio):4.6214895
Number of Samples:2 / 2
Experimental valproic acid study 25 (5000uM)
Hepatocytes treated with compound: valproic acid (5000uM; CHEMBL109) for 24 hours. ATC code:
Control vehicle (medium) treated hepatocyte sample
Hepatocytes treated with vehicle (medium) for 24 hours.

glioma study 16 (LN-18) / normal astrocyte sample

Relative Expression (log2-ratio):3.731906
Number of Samples:2 / 3
Experimental glioma study 16 (LN-18)
Human glioma cell line LN018 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

HCC study 20 (CDX; Hep-G2; orthotopic) / HCC study 20 (PDX; orthotopic)

Relative Expression (log2-ratio):-3.7033367
Number of Samples:5 / 11
Experimental HCC study 20 (CDX; Hep-G2; orthotopic)
Tumor tissue biopsy samples from Hep-G2 cell line-derived xenograft (CDX) orthotopically generated in SCID mice by injecting hepatocellular carcinoma cells directly into liver parenchyma. In order to establish orthotopic model, the left lobe of liver was exposed through midline abdominal incision and cells were injected directly into liver parenchyma of mice. The mice were euthanized after two weeks.
Control HCC study 20 (PDX; orthotopic)
Tumor tissue biopsy samples from patient-derived xenograft (PDX) sample orthotopically generated in SCID mice by injecting hepatocellular carcinoma cells directly into liver parenchyma. Donor tumor tissue was obtained intraoperatively during liver resection from three patients. All three patients had hepatocellular carcinoma confirmed by histology. In order to establish orthotopic model, the left lobe of liver was exposed through midline abdominal incision and cells were injected directly into liver parenchyma of mice. The mice were euthanized after two weeks.

hepatocyte (ESC) / HepaRG

Relative Expression (log2-ratio):-3.4983692
Number of Samples:8 / 12
Experimental hepatocyte (ESC)
Hepatocyte-like cells differentiated from embryonic stem cells (ESC)
Control HepaRG
Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code:

valproic acid study 24 (5000uM) / vehicle (medium) treated hepatocyte sample

Relative Expression (log2-ratio):3.3847694
Number of Samples:2 / 2
Experimental valproic acid study 24 (5000uM)
Hepatocytes treated with compound: valproic acid (5000uM; CHEMBL109) for 8 hours. ATC code:
Control vehicle (medium) treated hepatocyte sample
Hepatocytes treated with vehicle (medium) for 8 hours.

colchicine study 7 (4000uM) / vehicle (medium) treated hepatocyte sample

Relative Expression (log2-ratio):3.383585
Number of Samples:2 / 2
Experimental colchicine study 7 (4000uM)
Hepatocytes treated with compound: colchicine (4000uM; CHEMBL107) for 24 hours. ATC code:
Control vehicle (medium) treated hepatocyte sample
Hepatocytes treated with vehicle (medium) for 24 hours.

2-(chloromethyl)pyridine hydrochloride study 1 (24h) / vehicle (DMSO) treated HepG2 cell sample

Relative Expression (log2-ratio):3.1074276
Number of Samples:3 / 7
Experimental 2-(chloromethyl)pyridine hydrochloride study 1 (24h)
HepG2 cells exposed to 300?M 2-(chloromethyl)pyridine hydrochloride in DMSO solvent for 24 hours. ATC code:---
Control vehicle (DMSO) treated HepG2 cell sample
HepG2 cells exposed to DMSO solvent for 24 hours.

HCC study 9 (HBV; HCV) / normal liver tissue

Relative Expression (log2-ratio):2.9989967
Number of Samples:2 / 10
Experimental HCC study 9 (HBV; HCV)
Liver tissue biopsy sample from patients with Hepatitis B and C infection related hepatocellular carcinoma (HCC) after resection.
Control normal liver tissue
Normal, non-tumor liver tissue.

male infertility study 1 (juvenile; Ad-) / normal testicular lobules tissue (mJS10)

Relative Expression (log2-ratio):2.9709911
Number of Samples:2 / 8
Experimental male infertility study 1 (juvenile; Ad-)
Human testicular lobules biopsy samples isolated from prepubescent patients with undescended testes. Testes of these children contained very low level of A-dark (Ad-) spermatogonial cells.
Control normal testicular lobules tissue (mJS10)
Biopsies of human testicular lobules isolated from fertile vasectomized adult men with normal spermatogenesis. Histological analysis classified samples as mJS10 (modified Johnsen score 10).