TOP TEN perturbations for NM_000406 (Homo sapiens)

Organism: Homo sapiens
Gene: NM_000406
Selected probe(set): 216341_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NM_000406 (216341_s_at) across 5339 perturbations tested by GENEVESTIGATOR:

medulloblastoma study 2 / non-tumor brain tissue

Relative Expression (log2-ratio):1.4196739
Number of Samples:4 / 9
Experimental medulloblastoma study 2
Primary tumor tissue sample from the infratentorial brain of pediatric patients with large-cell anaplastic medulloblastoma.
Control non-tumor brain tissue
Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor.

male infertility study 1 (juvenile; Ad+) / normal testicular lobules tissue (mJS10)

Relative Expression (log2-ratio):1.3472233
Number of Samples:5 / 8
Experimental male infertility study 1 (juvenile; Ad+)
Human testicular lobules biopsy samples isolated from prepubescent patients with undescended testes. Testes of these children contained typical level of A-dark (Ad+) spermatogonial cells.
Control normal testicular lobules tissue (mJS10)
Biopsies of human testicular lobules isolated from fertile vasectomized adult men with normal spermatogenesis. Histological analysis classified samples as mJS10 (modified Johnsen score 10).

adrenal gland cancer study 5 (ACC) / AIMAH study 1

Relative Expression (log2-ratio):1.238595
Number of Samples:34 / 10
Experimental adrenal gland cancer study 5 (ACC)
Primary tumor tissue samples of the adrenal cortex from patients with adrenocortical carcinoma (ACC).
Control AIMAH study 1
Adrenal gland tissue samples from patients with ACTH-independant macronodular adrenal hyperplasia (AIMAH).

PBDE study 1 (2-OH-BDE47) / vehicle (DMSO) treated H295R cell sample

Relative Expression (log2-ratio):-1.1649075
Number of Samples:3 / 3
Experimental PBDE study 1 (2-OH-BDE47)
H295R adrenocortical carcinoma cells treated for 24 hours with 10?M of a hydroxylated form of the brominated flame retardant 2-OH-BDE47 dissolved in 0.1% dimethyl sulfoxide (DMSO). ATC code:---
Control vehicle (DMSO) treated H295R cell sample
H295R adrenocortical carcinoma cells grown for 24 hours with 0.1% dimethyl sulfoxide (DMSO).

adrenal gland cancer study 5 (ACC) / adrenal gland cancer study 5 (ACA)

Relative Expression (log2-ratio):1.133461
Number of Samples:34 / 58
Experimental adrenal gland cancer study 5 (ACC)
Primary tumor tissue samples of the adrenal cortex from patients with adrenocortical carcinoma (ACC).
Control adrenal gland cancer study 5 (ACA)
Primary tumor tissue samples of the adrenal cortex from patients with adrenocortical adenoma (ACA).

medulloblastoma study 2 / medulloblastoma study 1

Relative Expression (log2-ratio):1.0629215
Number of Samples:4 / 17
Experimental medulloblastoma study 2
Primary tumor tissue sample from the infratentorial brain of pediatric patients with large-cell anaplastic medulloblastoma.
Control medulloblastoma study 1
Primary tumor tissue sample from the infratentorial brain of pediatric patients with classical medulloblastoma.

PBDE study 1 (2-OH-BDE85) / PBDE study 1 (2-OH-BDE47)

Relative Expression (log2-ratio):1.0030203
Number of Samples:3 / 3
Experimental PBDE study 1 (2-OH-BDE85)
H295R adrenocortical carcinoma cells treated for 24 hours with 10?M of a hydroxylated form of the brominated flame retardant 2-OH-BDE85 dissolved in 0.1% dimethyl sulfoxide (DMSO). ATC code:---
Control PBDE study 1 (2-OH-BDE47)
H295R adrenocortical carcinoma cells treated for 24 hours with 10?M of a hydroxylated form of the brominated flame retardant 2-OH-BDE47 dissolved in 0.1% dimethyl sulfoxide (DMSO). ATC code:---

adrenal gland cancer study 2 / adrenal gland cancer study 1

Relative Expression (log2-ratio):0.98734474
Number of Samples:31 / 22
Experimental adrenal gland cancer study 2
Primary tumor tissue samples of the adrenal cortex from patients with adrenocortical carcinoma.
Control adrenal gland cancer study 1
Primary tumor tissue samples of the adrenal cortex from patients with adrenocortical adenoma.

engineered skin substitute study 2 (early) / engineered skin substitute study 1 (early)

Relative Expression (log2-ratio):0.8454447
Number of Samples:6 / 2
Experimental engineered skin substitute study 2 (early)
Human skin substitutes tissue samples collected after 3 and 7 days after transplantation to athymic mice.
Control engineered skin substitute study 1 (early)
Human skin substitutes tissue samples collected after 3 days in culture.

normal skeletal muscle tissue (pre-training; active) / normal skeletal muscle tissue (pre-training; sedentary)

Relative Expression (log2-ratio):0.80357075
Number of Samples:17 / 24
Experimental normal skeletal muscle tissue (pre-training; active)
Vastus lateralis muscle tissue biopsy samples from 17 young healthy active Caucasian men. Resting skeletal muscle biopsies were taken before the endurance training program. Average parameters of patients were: age=29?6 y, height=1.82?0.5 m, body mass=81.8?9 kg, VO2max=4.1?0.5 L.min-1.
Control normal skeletal muscle tissue (pre-training; sedentary)
Vastus lateralis muscle tissue biopsy samples from 24 young sedentary healthy Caucasian men. Resting skeletal muscle biopsies were taken before the endurance training program. Average parameters of patients were: age=23?1 y, height=1.82?0.02 m, body mass=78.6?2.7 kg, VO2max=3.71?0.55 L.min-1.