TOP TEN perturbations for NP_689760 (Homo sapiens)

Organism: Homo sapiens
Gene: NP_689760
Selected probe(set): 228434_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NP_689760 (228434_at) across 6593 perturbations tested by GENEVESTIGATOR:

lung adenocarcinoma study 3 (positive) / normal lung tissue

Relative Expression (log2-ratio):-4.855667
Number of Samples:7 / 3
Experimental lung adenocarcinoma study 3 (positive)
Primary lung adenocarcinoma samples, with bone marrow positive for early disseminated tumor cells (DTCs). The presence of DTCs can predict the subsequent occurrence of overt metastasis and survival in lung cancer.
Control normal lung tissue
Normal lung tissue.

breast cancer study 8 (primary) / normal breast tissue

Relative Expression (log2-ratio):-4.8182344
Number of Samples:13 / 4
Experimental breast cancer study 8 (primary)
Human primary infiltrating ductal carcinoma sample of a female patient with breast cancer.
Control normal breast tissue
Normal human breast samples of healthy female individuals.

breast cancer study 8 (metastatic) / normal breast tissue

Relative Expression (log2-ratio):-4.6864395
Number of Samples:2 / 4
Experimental breast cancer study 8 (metastatic)
Human metastatic infiltrating ductal carcinoma sample of the breast derived from lymph nodes of a female patient with breast cancer.
Control normal breast tissue
Normal human breast samples of healthy female individuals.

lung adenocarcinoma study 3 (negative) / normal lung tissue

Relative Expression (log2-ratio):-4.3940287
Number of Samples:9 / 3
Experimental lung adenocarcinoma study 3 (negative)
Primary lung adenocarcinoma samples, with bone marrow negative for early disseminated tumor cells (DTCs). The presence of DTCs can predict the subsequent occurrence of overt metastasis and survival in lung cancer.
Control normal lung tissue
Normal lung tissue.

rapidly progressive glomerulonephritis; ANCA-associated vasculitis study 5 (tubulointerstitium) / focal segmental glomerulosclerosis study 9 (glomerulus)

Relative Expression (log2-ratio):-4.2658796
Number of Samples:21 / 10
Experimental rapidly progressive glomerulonephritis; ANCA-associated vasculitis study 5 (tubulointerstitium)
Tubulointerstitium tissue sample obtained by microdissection from kidney biopsy, from patients suffering from rapidly progressive glomerulonephritis and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Donors were positive for ANCA-antibody. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist.
Control focal segmental glomerulosclerosis study 9 (glomerulus)
Glomeruli tissue sample obtained by microdissection from kidney biopsy, from patients suffering from focal segmental glomerulosclerosis. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist.

lung adenocarcinoma study 6 (K-RAS mut) / adjacent lung tissue

Relative Expression (log2-ratio):-4.090803
Number of Samples:6 / 20
Experimental lung adenocarcinoma study 6 (K-RAS mut)
Primary tumor sample from patients with stage II adenocarcinoma carrying a K-RAS mutation.
Control adjacent lung tissue
Adjacent and histologically normal, non-tumorous lung tissue samples from patients with lung adenocarcinoma.

breast cancer study 15 (inv. dc) / normal breast tissue

Relative Expression (log2-ratio):-4.0719957
Number of Samples:5 / 5
Experimental breast cancer study 15 (inv. dc)
Primary invasive ductal carcinoma tissue sample derived from the breasts of female patients after surgery.
Control normal breast tissue
Tissue samples of the breast from healthy female individuals after breast reduction surgery.

breast cancer study 16 (inv. dc) / adjacent breast tissue

Relative Expression (log2-ratio):-3.8290424
Number of Samples:22 / 27
Experimental breast cancer study 16 (inv. dc)
Primary invasive ductal carcinoma tissue sample derived from the breasts of female patients after surgery.
Control adjacent breast tissue
Histologically normal breast tissue samples obtained from a clinically unaffected site from patients with primary invasive breast cancer.

DLBCL study 7 (plasmablast-like) / DLBCL study 7 (centroblast-like)

Relative Expression (log2-ratio):-3.7898989
Number of Samples:2 / 2
Experimental DLBCL study 7 (plasmablast-like)
Primary tumor samples from patients with unclassified diffuse large B-cell lymphoma. Samples were also classified based on subset-specific B-cell-associated gene signature (BAGS) and assigned to plasmablast-like group. Patients were treated according to standard protocols, and comparable doses of RCHOP- like regimens were used. No patient was treated with stem cell transplantation.
Control DLBCL study 7 (centroblast-like)
Primary tumor samples from patients with unclassified diffuse large B-cell lymphoma. Samples were also classified based on subset-specific B-cell-associated gene signature (BAGS) and assigned to centroblast-like group. Patients were treated according to standard protocols, and comparable doses of RCHOP- like regimens were used. No patient was treated with stem cell transplantation.

lung adenocarcinoma study 6 (EGFR mut) / adjacent lung tissue

Relative Expression (log2-ratio):-3.738884
Number of Samples:24 / 20
Experimental lung adenocarcinoma study 6 (EGFR mut)
Primary tumor sample from patients with stage II adenocarcinoma carrying an EGFR mutation.
Control adjacent lung tissue
Adjacent and histologically normal, non-tumorous lung tissue samples from patients with lung adenocarcinoma.