TOP TEN perturbations for NP_751951 (Homo sapiens)

Organism: Homo sapiens
Gene: NP_751951
Selected probe(set): 221095_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of NP_751951 (221095_s_at) across 6593 perturbations tested by GENEVESTIGATOR:

gastric cancer study 2 / normal gastric tissue

Relative Expression (log2-ratio):-5.3067875
Number of Samples:12 / 3
Experimental gastric cancer study 2
Tumor samples from Chinese patients with gastric cancer.
Control normal gastric tissue
Normal gastric biopsy samples of Chinese individuals.

MALT lymphoma study 1 / normal spleen tissue

Relative Expression (log2-ratio):4.371418
Number of Samples:8 / 6
Experimental MALT lymphoma study 1
Human t(11;18)-negative mucosa-associated lymphoid tissue (MALT) lymphoma cells.
Control normal spleen tissue
Normal human spleen tissue sample.

gastric cancer study 2 / gastric cancer study 3 (adjacent)

Relative Expression (log2-ratio):-3.8119802
Number of Samples:12 / 12
Experimental gastric cancer study 2
Tumor samples from Chinese patients with gastric cancer.
Control gastric cancer study 3 (adjacent)
Normal gastric tissue samples adjacent to tumor from Chinese patients with gastric cancer.

gastric cancer study 1 (MSI) / adjacent gastric mucosa tissue

Relative Expression (log2-ratio):-3.1845894
Number of Samples:19 / 29
Experimental gastric cancer study 1 (MSI)
Tumor biopsies from patients with microsatellite instability (MSI) gastric cancer.
Control adjacent gastric mucosa tissue
Adjacent normal tissue biopsies from patients with gastric cancer.

gastric cancer study 1 (MSS) / adjacent gastric mucosa tissue

Relative Expression (log2-ratio):-3.1665554
Number of Samples:19 / 29
Experimental gastric cancer study 1 (MSS)
Tumor biopsies from patients with chromosome instability (microsatellite stable; MSS) gastric cancer.
Control adjacent gastric mucosa tissue
Adjacent normal tissue biopsies from patients with gastric cancer.

MALT lymphoma study 2 / MALT lymphoma study 1

Relative Expression (log2-ratio):-3.0782957
Number of Samples:6 / 8
Experimental MALT lymphoma study 2
Human t(11;18)-positive mucosa-associated lymphoid tissue (MALT) lymphoma cells.
Control MALT lymphoma study 1
Human t(11;18)-negative mucosa-associated lymphoid tissue (MALT) lymphoma cells.

dimethyloxalylglycine study 2 (175140ng/ml) / vehicle (DME) treated bronchial epithelial cell sample

Relative Expression (log2-ratio):2.1259375
Number of Samples:3 / 17
Experimental dimethyloxalylglycine study 2 (175140ng/ml)
Bronchial epithelial cells (NHBE) treated with dimethyloxalylglycine (175140ng/ml; vendor: Cayman Chemical / catalog number: CAYM71210-10 / catalog name: dimethyloxallyl glycine) for 6 hours. For treatment primary cells were seeded at a density of 50'000 cells/well in pre-coated rat tail collagen type I 96-well plates for 24 hours followed by 4 hours starvation. NHBE cells were isolated from different Caucasian, healthy and non-smoker donors from the airway located above the bifurcation of the lungs (tracheal/bronchial). ATC code:---
Control vehicle (DME) treated bronchial epithelial cell sample
Bronchial epithelial cells (NHBE) treated with vehicle (DME) for 6 hours. For treatment primary cells were seeded at a density of 50'000 cells/well in pre-coated rat tail collagen type I 96-well plates for 24 hours followed by 4 hours starvation. NHBE cells were isolated from different Caucasian, healthy and non-smoker donors from the airway located above the bifurcation of the lungs (tracheal/bronchial).

pancreatic cancer study 3 (ipmn) / pancreatic cancer study 3 (ipma)

Relative Expression (log2-ratio):-2.0294409
Number of Samples:3 / 6
Experimental pancreatic cancer study 3 (ipmn)
Intraductal papillary mucinous neoplasm from patients with pancreatic cancer.
Control pancreatic cancer study 3 (ipma)
Intraductal papillary mucinous adenoma from patients with pancreatic cancer.

Barrett's esophagus study 3 / esophageal squamous cell carcinoma study 1

Relative Expression (log2-ratio):1.7558861
Number of Samples:17 / 8
Experimental Barrett's esophagus study 3
Esophageal epithelium samples from areas with Barrett's esophagus metaplasia which were recovered by laser capture microdissection.
Control esophageal squamous cell carcinoma study 1
Esophageal squamous cell carcinoma (ESCC) biopsy samples from chemotherapy-naive patients with histological grading G1 (well differentiated) and UICC stage II and III, which undergone esophagectomy.

Barrett's esophagus study 3 / normal esophageal epithelium sample

Relative Expression (log2-ratio):1.687087
Number of Samples:17 / 18
Experimental Barrett's esophagus study 3
Esophageal epithelium samples from areas with Barrett's esophagus metaplasia which were recovered by laser capture microdissection.
Control normal esophageal epithelium sample
Histologically normal esophageal squamous cell epithelium biopsy samples from patients that were investigated for esophageal pain, but diagnosed as healthy.