TOP TEN perturbations for B1ATL7 (Homo sapiens)

Organism: Homo sapiens
Gene: B1ATL7
Selected probe(set): 240043_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of B1ATL7 (240043_at) across 5654 perturbations tested by GENEVESTIGATOR:

CH5183284 study 1 (MFE-280) / vehicle (DMSO) treated MFE-280 cell sample

Relative Expression (log2-ratio):2.9719334
Number of Samples:2 / 2
Experimental CH5183284 study 1 (MFE-280)
Human endometrial cell line MFE-280 treated with 1 uM of FGFR inhibitor CH5183284 for 24 hours. ATC code:---
Control vehicle (DMSO) treated MFE-280 cell sample
Human endometrial cell line MFE-280 treated with 0.1% DMSO for 24 hours.

strabismus study 1 / normal extraocular medial rectus muscle tissue

Relative Expression (log2-ratio):-1.884593
Number of Samples:3 / 4
Experimental strabismus study 1
Human extraocular medial rectus muscle tissue sample obtained from patients with strabismus after strabismus correction surgery.
Control normal extraocular medial rectus muscle tissue
Postmortem human extraocular medial rectus tissue samples from healthy donors without any ophthalmologic disease.

bronchial epithelial cell differentiation study 1 (day28) / bronchial epithelial cell differentiation study 1 (subconfluent)

Relative Expression (log2-ratio):1.8701277
Number of Samples:3 / 3
Experimental bronchial epithelial cell differentiation study 1 (day28)
Differentiated normal human bronchial epithelial cell (NHBE) cultured for 28 days in an air-liquid interface (ALI) system. At this time point cells were fully differentiated and formed a polarized, pseudostratified mucociliary epithelium. In order to generate the ALI culture, undifferentiated cells were grown under submerged conditions in bronchial air-liquid interface (B-ALI) growth basal medium supplemented with expansion media. When cells reached confluency (after 3-5 days), an air-liquid interface culture (ALI system) was created by removing the apical medium and replacing the medium of the basal compartment with B-ALI differentiation medium. During the 28 days culture medium was replaced every 48 hour.
Control bronchial epithelial cell differentiation study 1 (subconfluent)
Subconfluent undifferentiated normal human bronchial epithelial cell (NHBE) cultured for 1-2 days under submerged conditions in bronchial air-liquid interface (B-ALI) growth basal medium supplemented with expansion media. At this time point cells still grew dispersed in the culture insert and covered 70% of the insert.

bronchial epithelial cell differentiation study 1 (day28) / bronchial epithelial cell differentiation study 1 (confluent)

Relative Expression (log2-ratio):1.8571458
Number of Samples:3 / 3
Experimental bronchial epithelial cell differentiation study 1 (day28)
Differentiated normal human bronchial epithelial cell (NHBE) cultured for 28 days in an air-liquid interface (ALI) system. At this time point cells were fully differentiated and formed a polarized, pseudostratified mucociliary epithelium. In order to generate the ALI culture, undifferentiated cells were grown under submerged conditions in bronchial air-liquid interface (B-ALI) growth basal medium supplemented with expansion media. When cells reached confluency (after 3-5 days), an air-liquid interface culture (ALI system) was created by removing the apical medium and replacing the medium of the basal compartment with B-ALI differentiation medium. During the 28 days culture medium was replaced every 48 hour.
Control bronchial epithelial cell differentiation study 1 (confluent)
Confluent undifferentiated normal human bronchial epithelial cell (NHBE) cultured for 3-5 days under submerged conditions in bronchial air-liquid interface (B-ALI) growth basal medium supplemented with expansion media. At this time point cells formed a monolayer covering the whole surface of the insert.

asthma study 30 (mixed AIP) / control nasal scrape sample (mixed AIP)

Relative Expression (log2-ratio):-1.829752
Number of Samples:9 / 2
Experimental asthma study 30 (mixed AIP)
Nasal scrape samples from asthmatic adult patients with mixed airway inflammatory phenotype (AIP).
Control control nasal scrape sample (mixed AIP)
Control nasal scrape samples from adult subjects with mixed airway inflammatory phenotype (AIP).

LPS study 4 / mock treated MONO-MAC-6 cell sample

Relative Expression (log2-ratio):1.5425224
Number of Samples:2 / 2
Experimental LPS study 4
MONO-MAC-6 (MM6) cells were treated with 10 ng/ml lipopolysaccharide (LPS). ATC code:---
Control mock treated MONO-MAC-6 cell sample
MONO-MAC-6 (MM6) cells mock treated.

exercise study 37 (OUT; post-exerc.) / exercise study 37 (YUT; post-exerc.)

Relative Expression (log2-ratio):1.1684437
Number of Samples:12 / 16
Experimental exercise study 37 (OUT; post-exerc.)
Vastus lateralis muscle biopsy sample from old, untrained (OUT) subjects (>80 years old) participating in a 12 weeks progressive resistance training (PRT). Sample was taken 4 hours after the first resistance exercise unit of the progressive resistance training.
Control exercise study 37 (YUT; post-exerc.)
Vastus lateralis muscle biopsy sample from young, untrained (YUT) subjects (20-30 years old) participating in a 12 weeks progressive resistance training (PRT). Sample was taken 4 hours after the first resistance exercise unit of the progressive resistance training.

mechanical injury study 1 (non-smoker; 7d) / mechanical injury study 1 (non-smoker; 0d)

Relative Expression (log2-ratio):1.1247549
Number of Samples:3 / 4
Experimental mechanical injury study 1 (non-smoker; 7d)
Bronchial epithelial cells of the large (2nd - 3rd order) bronchi from healthy non-smokers were sampled 7 days after mechanical injury by airway brushing during bronchoscopy. Disposable brushes (2.0 mm) were used to injure airway epithelial cells by gently gliding the brush back and forth 10 times in different locations in the same general area. Individuals were determined to be phenotypically normal based on standard history, physical exam, complete blood count, coagulation studies, liver function tests, urine studies, chest X-ray, EKG, and pulmonary function tests.
Control mechanical injury study 1 (non-smoker; 0d)
Bronchial epithelial cells of the large (2nd - 3rd order) bronchi from healthy non-smokers were sampled at rest before airway brushing (day 0) during bronchoscopy. Disposable brushes (2.0 mm) were used to injure airway epithelial cells by gently gliding the brush back and forth 10 times in different locations in the same general area. Individuals were determined to be phenotypically normal based on standard history, physical exam, complete blood count, coagulation studies, liver function tests, urine studies, chest X-ray, EKG, and pulmonary function tests.

embryonic development study 1 (9wk) / embryonic development study 1 (4wk)

Relative Expression (log2-ratio):1.0339298
Number of Samples:3 / 3
Experimental embryonic development study 1 (9wk)
Human embryos at 9th week after fertilization. Embryos were obtained after therapeutic termination of pregnancy with mifepristone.
Control embryonic development study 1 (4wk)
Human embryos at 4th week after fertilization. Embryos were obtained after therapeutic termination of pregnancy with mifepristone.

glycogen storage disease type II study 1 / normal biceps tissue

Relative Expression (log2-ratio):-1.0013046
Number of Samples:8 / 10
Experimental glycogen storage disease type II study 1
Biceps femoris muscle biopsy sample from patients with infantile onset Morbus Pompe (Pompe disease).
Control normal biceps tissue
Biceps femoris biopsy muscle samples from control subjects.